Results 191 to 200 of about 219,778 (281)

A novel adaptor protein, ARAP, orchestrates Fcγ receptor signaling in mouse dendritic cells via Rap1 activation and NF‐κB‐mediated cytokine production

Immunology &Cell Biology, EarlyView.
ARAP selectively regulates FcγR‐mediated signaling in dendritic cells. Loss of ARAP impairs phosphorylation of key signaling proteins, Rap1 activation, and integrin‐mediated adhesion, as well as NF‐κB p65 nuclear translocation and downstream cytokine production.
Chohee Park, Mi Jin Yu, Jong Ran Lee
wiley   +1 more source

The PI3K/AKT signaling networks in cancer glucose metabolism: mechanisms and therapeutic implications. [PDF]

Transl Oncol
Cheng S, Jiang Q, Huang H, Tong H, Xie M.   +4 more
europepmc   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

Phosphoinositide kinase PIKfyve inhibitor apilimod blocks hepatitis E virus infection. [PDF]

eGastroenterology
Ring JJ, Schlienkamp S, Goussain Darido ML, Zhang X, Pinto Veiga O, Haase JA, Richter E, Gömer A, Fu RM, Dao Thi VL, Ulrich RG, Klöhn M, Todt D, Bader V, Winklhofer KF, Kinast V, Neyts J, Kaptein SJF, Steinmann E, Brüggemann Y.   +19 more
europepmc   +1 more source

Allele-specific KRAS signaling: shaping tumor immunity and therapeutic response in lung adenocarcinoma. [PDF]

Signal Transduct Target Ther
Papavassiliou KA, Stravopodis DJ, Papavassiliou AG.   +2 more
europepmc   +1 more source

Role of the PI3K/AKT signaling pathway in regulating gene expression in rheumatoid arthritis (Review). [PDF]

Mol Med Rep
Cong C, Wang Y, Liu J, Jin C.
europepmc   +1 more source

Understanding exosomes in facial esthetics and skin aging

Periodontology 2000, EarlyView.
Abstract Background Skin aging is a multifactorial process mediated by intrinsic (genetic and metabolic) and extrinsic (environmental) factors leading to functional and structural deterioration, including wrinkles, loss of collagen and elastin, as well as various pigmentation disorders.
Richard J. Miron, Catherine Davies, Anton Sculean, Paras Ahmad   +3 more
wiley   +1 more source

Disrupting resistance: novel therapeutic approaches to combat multidrug resistance in fusion-negative rhabdomyosarcoma. [PDF]

Cancer Drug Resist
Codenotti S, Marampon F, Megiorni F, Cattaneo CG, Gastaldello S, Pozzo E, Sampaolesi M, Rota R, Keller C, Fanzani A.   +9 more
europepmc   +1 more source

Understanding exosomes in regenerative dentistry

Periodontology 2000, EarlyView.
Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad, Anton Sculean, Richard J. Miron   +2 more
wiley   +1 more source

A PI(3,5)P₂/CHMP4B axis on lysosomes is essential for microautophagic degradation of STING. [PDF]

Nat Commun
Shoji T, Shinojima A, Kishimoto T, Sato K, Ikegami N, Yumoto E, Shindo R, Uchida Y, Kusumi S, Koga D, Yamamoto E, Hirano Y, Ogino R, Shibata H, Izawa K, Yasumi T, Sato R, Nakayama J, Higashiyama S, Hasegawa J, Kajiho H, Sasaki T, Kuchitsu Y, Taguchi T.   +23 more
europepmc   +1 more source