Results 81 to 90 of about 19,152,238 (244)

Structural Basis of Lymphangiogenic Receptor VEGFR‐3 Activation Mediated by Distinctive Clustering of the Ligand–Receptor Complex

Advanced Science, EarlyView.
VEGF‐C and its receptor VEGFR‐3 are critical for lymphangiogenesis. Cryo‐EM structures of the VEGFR‐3/VEGF‐C ectodomain complex reveal a canonical 2:2 ligand–receptor hetero‐tetramer that further assembles into higher‐order clusters beyond simple receptor dimerization.
Ryeongeun Cho, Jinsook Ahn, Jimin Yang, Dong Sun Lee, Gahi Hong, Sangkyu Lee, Ho Min Kim   +6 more
wiley   +1 more source

Beyond Conventional: A Review of Phytochemical‐Hydrogel Systems Enhanced by AI and 3D Printing for Chronic Wound Management

Advanced Science, EarlyView.
This review systematically bridges chronic wound pathology with natural phytochemical hydrogel therapeutics. A pathology‐to‐phytochemical mechanistic mapping framework is established, linking specific wound hallmarks to targeted phytochemical interventions.
Yitao Zhou, Xing Liu, Cuiyi Wang, Xiaoxuan Zhao, Pengrun Zhang, Jingjing Gu, Qiuhua Sun, Malcolm Xing, Yeqin Yang   +8 more
wiley   +1 more source

Sonogenetics Nanomedicine Activates the cGAS‐STING Pathway for Immunotherapy of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
A HER3‐targeted sonogenetic lipid nanoparticle platform is developed for triple‐negative breast cancer therapy. An AI‐designed miniprotein inhibits HER3 signaling, while TRPV4 and NFAT‐responsive IL‐15 plasmids enable ultrasound‐controlled calcium signaling and cytokine expression. The system induces Ca2+ overload, ROS generation, mitochondrial damage,
Junya Song, Yan Liu, Shifeng Zhao, Cheng Zhu, Hongchang Guo, Jin Chang, Jun Kang   +6 more
wiley   +1 more source

Liquid‐Responsive Shape‐Memory Nanofiber‐Reinforced Scaffolds for Cartilage Repair

Advanced Science, EarlyView.
A liquid‐responsive shape‐memory, nanofiber‐reinforced QCG scaffold combines conformal defect filling, an aligned architecture that is structurally permissive for endogenous cell infiltration, and sustained KGN release. This integrated design enhances BMSC viability, migratory activity, and chondrogenic differentiation and promotes hyaline cartilage ...
Jiyang Zeng, Wei Li, Yawei Li, Zhiming Tu, Hong Ma, Yuliang Dai, Zhaoling Ma, Tao Yuan, Bing Wang   +8 more
wiley   +1 more source

Targeting Polo-Like Kinases: A Promising Therapeutic Approach for Cancer Treatment

Translational Oncology, 2015
Polo-like kinases (Plks) are a family of serine-threonine kinases that regulate multiple intracellular processes including DNA replication, mitosis, and stress response.
Xiaoqi Liu
doaj   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Phosphatidylinositol 3-monophosphate is involved in Toxoplasma apicoplast biogenesis [PDF]

, 2011
Apicomplexan parasites cause devastating diseases including malaria and toxoplasmosis. They harbour a plastid-like, non-photosynthetic organelle of algal origin, the apicoplast, which fulfils critical functions for parasite survival.
Henri J Vial, Dubremetz, J.-F., Payrastre, B., Merezegue, F., Montcourrier, Philippe, Merezegue, Fabrice, Jean-François Dubremetz, Tawk, Lina, Payrastre Bernard, Chicanne Gaëtan, Payrastre, Bernard, Roy Christian, Philippe Montcourrier, Lebrun Maryse, Vial, H.J., Vial Henri J., Véronique Richard, Henri J. Vial, Roy, C., Dubremetz Jean-François, Markus Meissner, Lebrun, M., Chicanne, G., Kai Wengelnik, Wengelnik Kai, Christian Roy, Wengelnik, Kai, Lina Tawk, Chicanne, Gaëtan, Montcourrier Philippe, Lebrun, Maryse, Bernard Payrastre, Vial, Henri, Roy, Christian, Fabrice Merezegue, Richard, V., Meissner, M., Meissner Markus, Richard Véronique, Tawk, L., Meissner, Markus, Gaëtan Chicanne, Maryse Lebrun, Tawk Lina, Merezegue Fabrice, Dubremetz, Jean-François, Wengelnik, K., Montcourrier, P., Richard, Véronique   +48 more
core   +2 more sources

Developing Metal–Polyphenol Network‐Based Single‐Protein Particle Encapsulation System for Sustained Release of Whey Protein to Mitigate Sarcopenia

Advanced Science, EarlyView.
Sarcopenia has emerged as a major health challenge in the aging population. Developing a sustained‐release system for whey protein may enhance its effectiveness in mitigating sarcopenia. Herein, a novel “single‐protein particle encapsulation” (SPPE) system is developed to protect whey protein and control its release.
Yafei Zhang, Yuning Zhang, Yongjian Ai, Yao Lu, Heng Quan, Zhen Zhang, Yuqi Wang, Yujia Luo, Xiaoxu Zhang, Yingying Lin, Sijia Song, Huiyuan Guo   +11 more
wiley   +1 more source

Precision diagnosis and treatment of breast cancer in the post-CDK4/6 inhibitor era [PDF]

Zhongguo aizheng zazhi
Cyclin-dependent kinase (CDK)4/6 inhibitors plus endocrine therapy represents the standard first-line treatment for patients with hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer. The introduction
LI Bin, TAO Zhonghua, HU Xichun
doaj   +1 more source

Ciliary Membrane Lipid Homeostasis in Health and Disease

Advanced Science, EarlyView.
This review systematically delineates the distinct lipid landscapes of ciliary membranes, including the spatial organization of phosphoinositides, cholesterol, and sphingolipids. It elucidates how these lipids orchestrate ciliogenesis, signal transduction, and membrane dynamics in cilia beating, and highlights how their dysregulation drives ...
Zhenzhou Huang, Yuan‐yuan Liu, Hanqi Sun, Peiwei Liu   +3 more
wiley   +1 more source