Results 301 to 310 of about 369,030 (389)

Non‐canonical PKG1 regulation in cardiovascular health and disease

open access: yesBritish Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Degradation of oxidized phospholipids by lysosomal phospholipase A2 regulates pulmonary fibrosis. [PDF]

open access: yesAm J Physiol Lung Cell Mol Physiol
Kwak D   +5 more
europepmc   +1 more source

Elucidation of the zinc binding site in KCNQ channels

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose KCNQ1‐5 (Kv7.1–7.5) are members of a family of voltage‐gated potassium channels with prominent function in the nervous and cardiovascular systems and in epithelia. KCNQ channels are activated by intracellular free zinc, but the molecular mechanism of this effect is poorly understood and zinc binding sites within KCNQ channels are
Shuo Zhang   +6 more
wiley   +1 more source

Overproduction and Characterization of Recombinant Soluble <i>Trypanosoma brucei</i> Phospholipase A<sub>2</sub>. [PDF]

open access: yesEng Life Sci
Adepoju OA   +9 more
europepmc   +1 more source

Exploring Siglecs: Potential Modulators of Immune Cells in Food Allergy and Therapeutic Applications

open access: yesClinical &Experimental Allergy, EarlyView.
Sialic acid‐binding immunoglobulin‐type lectins (Siglecs) are inhibitory receptors present on all immune cells involved in the allergic reaction. Currently, research is mostly focussed on targeting Siglecs on mast cells to possibly treat food allergies.
J. S. H. Schaapherder   +5 more
wiley   +1 more source

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