Results 171 to 180 of about 300,277 (292)

Folic Acid‐Modified Ginger‐Derived Exosome‐Like Nanoparticles Co‐Delivering Sunitinib Suppress Renal Cell Carcinoma via PI3K‐Akt Pathway Inhibition, P‐gp Downregulation, and Macrophage Reprogramming

Advanced Science, EarlyView.
FPD‐GELNs co‐deliver Su and bioactive components. This active‐passive dual‐targeting strategy suppresses the progression of RCC through the following mechanisms: 1) inhibition of the PI3K‐Akt signaling pathway; 2) downregulation of ABCB1/P‐gp to enhance the chemosensitivity of RCC to Su; and 3) reprogramming of macrophages toward M1 polarization and ...
Haoyu Xu, Daixing Hu, Shixue Liu, Lei Yang, Junwu Li, Yuanyuan Bai, Guozhi Zhao, Wei Tang, Li Jiang   +8 more
wiley   +1 more source

Downregulation of PCYT2 by increased portal pressure safeguards liver regeneration after partial hepatectomy. [PDF]

Theranostics
Pu G, Song Y, Li Q, Duan J, Wang G, Xiu W, Xu J, Zhao X, Dong W, Lan T, Ai R, Zhang J, Sun W, Kong D, Zhu Y, Zhang X, Liu Y, Wang C.   +17 more
europepmc   +1 more source

Effect of SAM-Dependent Methyltransferases from Halomonas sp. YLGW01 on Phospholipid Fatty Acids Composition and Production of Polyhydroxalkanoates in Escherichia coli

Tae‐Rim Choi, Gaeun Lim, Ye Sun Han, Jong‐Min Jeon, Jeonghee Yun, Jeong‐Jun Yoon, Shashi Kant Bhatia, Yung-Hun Yang   +7 more
openalex   +2 more sources

Pulmonary‐Targeted Nanoparticles Interrupt the Malignant Mechanical and Biochemical Signaling Crosstalk for Idiopathic Pulmonary Fibrosis Therapy

Advanced Science, EarlyView.
Idiopathic pulmonary fibrosis (IPF) progression is driven by TGF‐β induced biochemical signals and mechanical signals from increased ECM stiffness. Pulmonary‐targeted VB‐RT NPs not only eliminate excessive ROS and penetrate the dense ECM collagen barrier via NO release, but also simultaneously interrupt the persistent malignant between mechanical and ...
Xue‐Na Li, Ya‐Ping Lin, Xi‐Xi Ma, Yue‐Fei Fang, Hui Wang, Chun‐Hui Cui, Chen Zhang, Jin‐You Piao, Jee‐Heon Jeong, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +11 more
wiley   +1 more source

Molecular mechanisms of CBASS phospholipase effector CapV mediated membrane disruption. [PDF]

Nat Commun
Kong J, Wu W, Ke S, Zhou Z, Xia S, Chen J, Zhu R, Hou Y, Makanyire T, Shan X, Zhuo Z, Li K, Shen H, Yang P, Huang P, Liu J, Li J, Sun X, Dong J, Sun H, Chen M, Lu M, Li Z, Xiao Y.   +23 more
europepmc   +1 more source

Image Fusion for Super‐Resolution Mass Spectrometry Imaging of Plant Tissue

Advanced Science, EarlyView.
A loss controlled residual network (LCRN) workflow is developed for super‐resolution fusion of plant mass spectrometry imaging data. LCRN uses a novel edge perceptual loss metric to preserve complex plant tissue morphology. LCRN achieves up to 20‐fold magnification while effectively combining chemical information from mass spectrometry with ...
Yuchen Zou, Shipeng Sun, Weiwei Tang, Bin Li   +3 more
wiley   +1 more source

Cerebral phosphorus metabolite as imaging biomarkers in Alzheimer's disease: a ³¹P magnetic resonance spectroscopy study. [PDF]

Neuroimage Clin
Zhao S, Dong Y, Jiang B, Bai Y, Wei W, Wu Y, Li C, Chen J, Wang M.   +8 more
europepmc   +1 more source

Genetically‐Programmed Hypervesiculation of Lactiplantibacillus Plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model

Advanced Science, EarlyView.
The development of a novel engineered strain of Lactiplantibacillus plantarum (Lp) is reported that can produce bacterial extracellular vesicles (BEVs) at >60‐fold higher yields than the unmodified parental strain. These Lp BEVs retain therapeutic bioactivity as validated in a mouse model of dextran sodium sulfate‐induced colitis.
Nicholas H Pirolli, Daniel Levy, Alyssa Schledwitz, Natalia Sampaio Moura, Mitali Sarkar, Talia J. Solomon, Emily H. Powsner, Raith Nowak, Zuzanna Mamczarz, Christopher J. Bridgeman, Sulayman Khan, Andrew Hui, Nidhi Anne, Laura Reus, William E. Bentley, Jean‐Pierre Raufman, Steven M. Jay   +16 more
wiley   +1 more source

Genomic Insights into Lipid Dependency in Atypical Strains of Malassezia pachydermatis. [PDF]

Mycopathologia
Díaz L, Castellá G, Cigliano RA, Sanseverino W, Cabañes FJ.   +4 more
europepmc   +1 more source

Ultrasound‐Boosted Liposomal Prodrug Overcomes Age‐Associated Biodistribution Disparity in Pediatric Solid Tumor Therapy

Advanced Science, EarlyView.
The age‐associated disparity of nanocarrier biodistribution limits the nanotherapeutics of childhood solid tumors. This study developed an ultrasound‐activated liposomal prodrug (CSCPTL) to overcome the age‐associated disparity of off‐target distribution.
Danfei Chen, Junjun Xu, Jian Chen, Jue Hu, Xiaobo Xuan, Haifang Cai, Mingdong Yang, Zhuxian Zhou, Guowei Wang   +8 more
wiley   +1 more source