Results 131 to 140 of about 207,054 (311)

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Intranuclear localization of phospholipids by ultrastructural cytochemistry.

, 1992
The presence of phospholipids within the interphase nucleus and in isolated chromatin, previously demonstrated by analytical biochemical methods, has been only rarely documented by cytochemical procedures, especially at the ultrastructural level.
N M Maraldi, P Sabatelli, F A Manzoli, N Zini, S Squarzoni, R Del Coco   +5 more
core   +1 more source

PHOSPHOLIPIDS. PHYSICOCHEMICAL PROPERTIES OF PHOSPHOLIPIDS

The article discusses the composition and physical and chemical properties of phospholipids and the study of the chemical composition of phospholipids. It also discusses the development of methods for identifying and establishing the chemical composition of phospholipids.
Tashmukhamedova, Shohista, Gulomova, Nazokat   +1 more
openaire   +1 more source

NUP85 Mediates Endoplasmic Reticulum Stress through the USP47/ASK1 Signaling Pathway to Regulate the Progression of Liver Fibrosis

Advanced Science, EarlyView.
In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang, Haoran Yang, Linxin Pan, Chang Tian, Fucheng Zuo, Shilei Huang, Xianrui Li, Ming Chen, Cheng Qian, Jie Wang, Zhaolin Chen, Tao Xu   +11 more
wiley   +1 more source

Self-assembly lipid-based nanoparticles containing zoledronic acid: a new strategy for the treatment of cancer

, 2011
Introduction: Zoledronic acid (ZOL), a third generation amino-bisphosphonate (A-BP), is actually, the most potent inhibitor of the bone resorption, largely used in clinic for the treatment of bone diseases (i.e.
C. Leonetti, M. Marra, S. Zappavigna, LA ROTONDA, MARIA IMMACOLATA, DE ROSA, GIUSEPPE, M. Porru, A. Abbruzzese, SALZANO, GIUSEPPINA, M. Caraglia   +8 more
core  

Synthetic scheme for the phospholipids.

, 2015
Synthetic scheme for the phospholipids.
Ying Sun (23237), Yourong Duan (688777), Hui Yu (27723), He Li (176971), Ming Shen (156685), Qi Wang (22418)   +5 more
core   +1 more source

Emulsions stabilized by phospholipids

Journal of Colloid and Interface Science
Phospholipids are amphiphilic molecules able to adsorb at oil/water interfaces and thus used to stabilize parenteral emulsions. Yet, their low preferred curvature, which sensitively depends on molecular structures and interactions, favors the formation of lamellar phases and sets constraints on the system formulation.
Jenny Marie Andersson, Olivier Masbernat, Kevin Roger   +2 more
openaire   +2 more sources

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Structures of synthesized isoprenoid phospholipids.

, 2017
Structures of synthesized isoprenoid phospholipids.
Anna Gliszczyńska (2839163), Witold Gładkowski (2839157), Marta Świtalska (2141767), Natalia Niezgoda (2839160), Joanna Wietrzyk (534260)   +4 more
core   +1 more source