Results 141 to 150 of about 532,032 (389)

Global changes in phospholipids identified by MALDI MS in rats with focal cerebral ischemia[S]

Journal of Lipid Research, 2012
Neuronal membrane phospholipids are highly affected by oxidative stress caused by ischemic injury. Thus, it is necessary to identify key lipid components that show changes during ischemia to develop an effective approach to prevent brain damage from ...
Selina Rahman Shanta, Chang Soon Choi, Jeong Hwa Lee, Chan Young Shin, Young Jun Kim, Kyun-Hwan Kim, Kwang Pyo Kim   +6 more
doaj   +1 more source

Diversified expression patterns of autotaxin, a gene for phospholipid‐generating enzyme during mouse and chicken development [PDF]

, 2007
Hideyo Ohuchi, Yasunori Hayashibaral, Hironao Matsuda, Motoyoshi Onoi, Masayuki Mitsumori, Masayuki Tanaka, Junken Aoki, Hiroyuki Arai, Sumihare Noji   +8 more
openalex   +1 more source

Photosensitizing Lipid Nanoparticles for Ferroptosis‐Enhanced Photodynamic Cancer Therapy via GPX4 Silencing

Advanced Healthcare Materials, EarlyView.
Photosensitizing lipid nanoparticles (PLNPs) are engineered by incorporating cholesterol–PEG–pheophorbide a into MC3‐based LNPs and encapsulating GPX4‐targeting siRNA. Upon light activation, PLNPs generate reactive oxygen species (ROS) while silencing GPX4 to induce ferroptosis.
Ga‐Hyun Bae, Seungyong Shin, Joo Dong Park, Eun‐Young Koh, Seunghyo Ko, Jieun Han, Chun Gown Park, Dong‐Hyun Kim, Kun Na, Wooram Park   +9 more
wiley   +1 more source

Dual‐Functional Polyphosphoesters for Gene Delivery: Synergistic Effects of Guanidinium and Hydrophobic Side Chains in Degradable Polymers

Advanced Healthcare Materials, EarlyView.
This study presents guanidinium‐ and indole‐functionalized polyphosphoesters as degradable, non‐viral gene delivery vectors. Through precise tuning of charge density and hydrophobicity, these polymers form stable polyplexes with low toxicity. Remarkably, minor structural changes yield up to 200‐fold differences in transfection efficiency, highlighting ...
Markus Kötzsche, Andreas Dzierza, Jan Egger, Timo Rheinberger, Christin Weilandt, Frederik R. Wurm, Ivo Nischang, Dagmar Fischer, Kalina Peneva   +8 more
wiley   +1 more source

Phosphatidylthreonine is a procoagulant lipid detected in human blood and elevated in coronary artery disease

Journal of Lipid Research
Aminophospholipids (aPL) such as phosphatidylserine are essential for supporting the activity of coagulation factors, circulating platelets, and blood cells.
Ali A. Hajeyah, Majd B. Protty, Divyani Paul, Daniela Costa, Nader Omidvar, Bethan Morgan, Yugo Iwasaki, Beth McGill, P. Vincent Jenkins, Zaheer Yousef, Keith Allen-Redpath, Shin Soyama, Anirban Choudhury, Rito Mitra, Parveen Yaqoob, James H. Morrissey, Peter W. Collins, Valerie B. O'Donnell   +17 more
doaj   +1 more source

Active and low-active forms of serum phospholipid transfer protein in a normal Finnish population sample [PDF]

, 2004
Minna T. Jänis, Sarah Siggins, Esa Tahvanainen, Riikka Vikstedt, Kaisa Silander, Jari Metso, Arpo Aromaa, Marja‐Riitta Taskinen, Vesa M. Olkkonen, Matti Jauhiainen, Christian Ehnholm   +10 more
openalex   +1 more source

Dendrimers Improve Apolipoprotein Nanoparticle mRNA Delivery to Immune Cells

Advanced Materials, EarlyView.
Apolipoprotein nanoparticle (aNP) platform technology efficiently delivers RNA to immune cells following systemic administration. Here, it is demonstrated that incorporating polyvalent ionizable cationic dendrimers in aNPs enables robust mRNA complexation and functional delivery.
Mirre M. Trines, Daniek Hoorn, Stijn R.J. Hofstraat, Robby C. Zwolsman, Tom Anbergen, Iris Versteeg, Yuri van Elsas, Jeroen Deckers, Merel M.A. Hendrikx, Teun Kleuskens, Youssef B. Darwish, Gijs W.B. Ros, Sjoerd F. Dijkstra, Bram Priem, Matt Timmers, P. Michel Fransen, Maarten J. Pouderoijen, Bas F.M. de Waal, E.W. Meijer, Thijs J. Beldman, Yohana C. Toner, Ewelina Kluza, Willem J.M. Mulder, Henk M. Janssen, Roy van der Meel   +24 more
wiley   +1 more source

Polyphenol‐Mediated Engineering of Lipid Nanoparticles With Crystalline Mesophases

Advanced Materials, EarlyView.
A polyphenol‐mediated strategy enables the one‐step formation of lipid nanoparticles with nonlamellar mesophases, including micellar cubic and hexagonal structures. These highly ordered nanostructures accommodate a wide range of cargos—from metal ions to mRNA—and offer a modular and versatile platform for constructing functional lipid‐based delivery ...
Shiyao Li, Patrick Charchar, Haitao Yu, Zhixing Lin, Hamish G. Brown, Wanjun Xu, Chan‐Jin Kim, Irene Yarovsky, Yi Ju, Frank Caruso   +9 more
wiley   +1 more source

LDI, A Lipid Droplet Inhibitor, Disrupts Lipid Accumulation and Modulates Hepatic Lipid Profiles in Fatty Liver

Advanced Materials, EarlyView.
The lipid droplet inhibitor (LDI), templated with large‐pore mesoporous silica and functionalized with PKCα C1A and lipase, targets lipid degradation in fatty liver. The LDI maintains stable association with lipid droplets, thereby suppressing their formation and expansion.
Seunghee Kim, Yeojin Kim, Sanjita Paudel, In Young Kang, Suyeon Kim, Jeesoo Kim, Sunmi Park, Seung‐Hoi Koo, Hyun Sung Kim, Dae Won Jun, Jinyoung Park, Hyunbeom Lee, Joonseok Lee   +12 more
wiley   +1 more source

Cell‐Stress‐Free Percutaneous Bioelectrodes

Advanced Materials, EarlyView.
A structurally adaptive soft microneedle bioelectrode is developed with an effervescent sacrificial core that dissolves after insertion, leaving an ultrathin and highly compliant electrode integrated with skin. This design enables ultra‐flexible, cell‐stress‐free, stable, and high‐fidelity electrophysiological monitoring under dynamic conditions such ...
Jungho Lee, Gaeun Yun, Juhyeong Jeon, Phuong Thao Le, Tae Sik Hwang, Jeongwoo Park, Jin‐Hyeok Baek, Seung Whan Kim, Hyoun Wook Lee, Kisang Kwon, Jihee Kim, Hoon Lim, Chulhong Kim, Sung‐Min Park, Geunbae Lim   +14 more
wiley   +1 more source