Results 11 to 20 of about 523,879 (387)

A review on phospholipids and their main applications in drug delivery systems

open access: yesAsian Journal of Pharmaceutical Sciences, 2015
Phospholipids have the characteristics of excellent biocompatibility and a especial amphiphilicity. These unique properties make phospholipids most appropriate to be employed as important pharmaceutical excipients and they have a very wide range of ...
Jing Li   +6 more
doaj   +2 more sources

Acyl chain asymmetry and polyunsaturation of brain phospholipids facilitate membrane vesiculation without leakage

open access: yeseLife, 2018
Phospholipid membranes form cellular barriers but need to be flexible enough to divide by fission. Phospholipids generally contain a saturated fatty acid (FA) at position sn1 whereas the sn2-FA is saturated, monounsaturated or polyunsaturated.
Marco M Manni   +5 more
doaj   +2 more sources

Phospholipids of Animal and Marine Origin: Structure, Function, and Anti-Inflammatory Properties

open access: yesMolecules, 2017
In this review paper, the latest literature on the functional properties of phospholipids in relation to inflammation and inflammation-related disorders has been critically appraised and evaluated.
Ronan Lordan   +2 more
doaj   +2 more sources

Membrane destabilizing ionizable phospholipids for organ selective mRNA delivery and CRISPR/Cas gene editing

open access: yesNature Materials, 2021
Endosomal escape remains a fundamental barrier hindering the advancement of nucleic acid therapeutics. Taking inspiration from natural phospholipids that comprise biological membranes, we report the combinatorial synthesis of multi-tailed ionizable ...
Shuai Liu   +6 more
semanticscholar   +1 more source

The Phospholipid Research Center: Current Research in Phospholipids and Their Use in Drug Delivery

open access: yesPharmaceutics, 2020
This review summarizes the research on phospholipids and their use for drug delivery related to the Phospholipid Research Center Heidelberg (PRC). The focus is on projects that have been approved by the PRC since 2017 and are currently still ongoing or ...
Simon Drescher, P. van Hoogevest
semanticscholar   +1 more source

Phospholipid—the dynamic structure between living and non-living world; a much obligatory supramolecule for present and future

open access: yesAIMS Molecular Science, 2019
Phospholipids (PLs) are amphiphilic molecules that are in charge of controlling what goes in or out of the cell, keeping up the structure and numerous associated functions.
Manikandan Alagumuthu   +2 more
doaj   +1 more source

Value of Ascitic Lipids in the Differentiation between Cirrhotic and Malignant Ascites [PDF]

open access: yes, 1986
Ascitic fluid concentrations of cholesterol, triglycerides and phospholipids, were compared with ascitic fluid total protein in 40 patients with chronic liver disease, 51patients with various neoplasms and 1 patient with cardiac failure.
Alexander L. Gerbes   +22 more
core   +1 more source

Phospholipid synthesis inside phospholipid membrane vesicles

open access: yesCommunications Biology, 2022
AbstractConstruction of living artificial cells from genes and molecules can expand our understanding of life system and establish a new aspect of bioengineering. However, growth and division of cell membrane that are basis of cell proliferation are still difficult to reconstruct because a high-yielding phospholipid synthesis system has not been ...
Sumie Eto   +6 more
openaire   +3 more sources

Do anionic phospholipids serve as cofactors or second messengers for the regulation of activity of cloned ATP-sensitive K+ channels? [PDF]

open access: yes, 2003
The regulation of ion channels by anionic phospholipids is currently very topical. An outstanding issue is whether phosphatidylinositol 4,5-diphosphate and related species act as true second messengers in signaling or behave in a manner analogous to an ...
Clapp, LH   +4 more
core   +1 more source

Substrate-Specific Inhibition Constants for Phospholipase A2 Acting on Unique Phospholipid Substrates in Mixed Micelles and Membranes Using Lipidomics. [PDF]

open access: yes, 2019
Assaying lipolytic enzymes is extremely challenging because they act on water-insoluble lipid substrates, which are normally components of micelles, vesicles, and cellular membranes.
Armando, Aaron   +2 more
core   +6 more sources

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