Results 41 to 50 of about 172,286 (260)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

PENGARUH KOMPOSOSI LAPISAN PADA PERMUKAAN GLOBULA MINYAK EMULSI SEBELUM PENGERINGAN SEMPROT TERHADAP SIFAT-SIFAT MIKROKAMSUL TRIGLISERIDA KAYA ASAM LEMAK W-3 [The Effect of the Composition of Adsorbed Layer at Globule Interface of -3 Fatty Acids Enriched Triglyceride Prior to Spray Drying on its Microcapsule Properties]

Jurnal Teknologi dan Industri Pangan, 2005
Emulsification is the critical factor in microencapsulation by spray drying method. Sodium caseinate is a protein with good emulsifying properties. The properties could be improved by phospholipids addition in the emulsification.
Moch Adnan2), Teti Estiasih1), Teti Estiasih1), Moch Adnan2), Tranggono2), Tranggono2), Suparmo2), Suparmo2)   +7 more
doaj  

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

The Effect of the Composition of Adsorbed Layer at Globule Interface of -3 Fatty Acids Enriched Triglyceride Prior to Spray Drying on its Microcapsule Properties

Jurnal Teknologi dan Industri Pangan, 2010
Emulsification is the critical factor in microencapsulation by spray drying method. Sodium caseinate is a protein with good emulsifying properties. The properties could be improved by phospholipids addition in the emulsification.
Teti Estiasih, Moch Adnan, Tranggono Tranggono, Suparmo .   +3 more
doaj  

Regulation of neutral cholesterol esterase activity by phospholipids containing negative charges in substrate liposome

Journal of Lipid Research, 1995
The effect of phospholipids on cholesteryl ester hydrolysis by neutral cholesterol esterase in alveolar macrophages was studied. Among the phospholipids used as emulsifiers, those with a negative charge, such as phosphatidylserine, phosphatidic acid ...
I Ishii, R Onozaki, E Takahashi, S Takahashi, N Fujio, T Harada, N Morisaki, K Shirai, Y Saito, S Hirose   +9 more
doaj   +1 more source

Determination of the Main Phase Transition Temperature of Phospholipids by Oscillatory Rheology

Molecules, 2023
Knowledge of the physical and chemical properties of phospholipids, such as phase transition temperatures (Tc), is of great importance in order to reveal the functionalities of biological and artificial membranes.
Lívia Budai, Marianna Budai, Tamás Bozó, Gergely Agócs, Miklós Kellermayer, István Antal   +5 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Acyl chain asymmetry and polyunsaturation of brain phospholipids facilitate membrane vesiculation without leakage

eLife, 2018
Phospholipid membranes form cellular barriers but need to be flexible enough to divide by fission. Phospholipids generally contain a saturated fatty acid (FA) at position sn1 whereas the sn2-FA is saturated, monounsaturated or polyunsaturated.
Marco M Manni, Marion L Tiberti, Sophie Pagnotta, Hélène Barelli, Romain Gautier, Bruno Antonny   +5 more
doaj   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Opsin Is a Phospholipid Flippase [PDF]

Current Biology, 2011
Polar lipids must flip-flop rapidly across biological membranes to sustain cellular life [1, 2], but flipping is energetically costly [3] and its intrinsic rate is low. To overcome this problem, cells have membrane proteins that function as lipid transporters (flippases) to accelerate flipping to a physiologically relevant rate.
Sakmar, TP, Menon, I, Huber, T, Sanyal, S, Banerjee, S, Barré, P, Canis, S, Warren, JD, Hwa, J, Menon, AK   +9 more
openaire   +4 more sources