Results 111 to 120 of about 25,010,716 (171)

Characterization of GDP-mannose Pyrophosphorylase from Escherichia Coli O157:H7 EDL933 and Its Broad Substrate Specificity

, 2005
GDP-mannose pyrophosphorylase gene (ManC) of Escherichia coli (E. coli) O157 was cloned and expressed as a highly soluble protein in E. coli BL21 (DE3). The enzyme was subsequently purified using hydrophobic and ion exchange chromatographies. ManC showed
Hwang, Bum-Yeol, Kang, Young Bok (Abraham), Kim, Byung-Gee, Lee, Kwang-Won, Lee, Tek-Hyung, Park, Sung-Soo, Yang, Yung-Hun   +6 more
core  

Trypanosoma brucei PRMT1 Is a Nucleic Acid Binding Protein with a Role in Energy Metabolism and the Starvation Stress Response. [PDF]

, 2018
In Trypanosoma brucei and related kinetoplastid parasites, transcription of protein coding genes is largely unregulated. Rather, mRNA binding proteins, which impact processes such as transcript stability and translation efficiency, are the predominant ...
Debler, Erik W., Kafková, Lucie, Paul, Kimberly S., Pazzo, Kyle L., Qu, Jun, Read, Laurie K., Smith, Kyle P., Tu, Chengjian   +7 more
core   +2 more sources

Unveiling Novel Arginase Inhibitors for Cutaneous Leishmaniasis Using Drug Repurposing and Virtual Screening Approaches

Journal of Cellular Biochemistry, Volume 126, Issue 8, August 2025.
ABSTRACT Leishmaniasis is a neglected tropical disease with a significant global health burden, particularly in developing countries, where it accounts for approximately 1.6 million new infections annually. Current therapeutic options are limited by severe adverse effects, toxicity, and drug resistance, highlighting the urgent need for novel treatment ...
Eduarda Moreira Barreto, Gabriel Rodrigues Coutinho Pereira, Isadora de Salles Arêas, Júlia Mendes Fortes, Alessandra da Silva Domingos, Lucio Mendes Cabral, Carlos Rangel Rodrigues, Alessandra Mendonça Teles de Souza, Barbara de Azevedo Abrahim‐Vieira   +8 more
wiley   +1 more source

The response of diatom central carbon metabolism to nitrogen starvation is different from that of green algae and higher plants [PDF]

, 2011
The availability of nitrogen varies greatly in the ocean and limits primary productivity over large areas. Diatoms, a group of phytoplankton that are responsible for about 20% of global carbon fixation, respond rapidly to influxes of nitrate and are ...
Hockin, Nicola Louise, Kopriva, Stanislav, Malin, Gill, Mock, Thomas, Mulholland, Francis   +4 more
core   +1 more source

Combined enhancement of ascorbic acid, β‐carotene and zeaxanthin in gene‐edited lettuce

Plant Biotechnology Journal, Volume 23, Issue 6, Page 1954-1967, June 2025.
Summary Lettuce is widely grown and consumed but provides lower nutritional value compared to other leafy greens, particularly in the essential vitamins A and C. To address this, major control points in carotenoid and ascorbic acid (AsA) production were targeted using a viral‐based CRISPR/Cas9 system in the commercial lettuce cultivar ‘Noga’.
Yarin Livneh, Ehud Leor‐Librach, Dor Agmon, Tal Makov‐Bouaniche, Vivekanand Tiwari, Ekaterina Shor, Yelena Yeselson, Tania Masci, Arthur Schaffer, Dana Charuvi, Joseph Hirschberg, Alexander Vainstein   +11 more
wiley   +1 more source

Exploring ligand interactions with human phosphomannomutases using recombinant bacterial thermal shift assay and biochemical validation [PDF]

PMM2-CDG, a disease caused by mutations in phosphomannomutase-2, is the most common congenital disorder of glycosylation. Yet, it still lacks a cure. Targeting phosphomannomutase-2 with pharmacological chaperones or inhibiting the phosphatase activity of
Andreotti, Giuseppina, Cubellis, Maria Vittoria, Guerriero, Simone, Mele, Bruno Hay, Monticelli, Maria, Wright, Demi Marie   +5 more
core   +1 more source

Additional file 1 of Dietary mannose supplementation in phosphomannomutase 2 deficiency (PMM2-CDG)

, 2020
Additional file 1: Figure S1. Layout showing the metabolic fate of mannose in mammalian cells. PMM2 is an essential enzyme catalyzing the conversion of mannose-6-phosphate to mannose-1- phosphate, which is the first step in the synthesis. Figure S2.
Taday, Roman, Grüneberg, Marianne, DuChesne, Ingrid, Reunert, Janine, Marquardt, Thorsten   +4 more
openaire   +1 more source

CCL20/CCR6 expression profile in pancreatic cancer [PDF]

, 2010
Background CCL20 and its receptor CCR6 have been shown to play a role in the onset, development and metastatic spread of various gastrointestinal malignancies.
Claudia Rubie, Vilma Frick, Pirus Ghadjar, Mathias Wagner, Henner Grimm, Benjamin Vicinus, Christoph Justinger, Stefan Graeber, Martin K Schilling   +8 more
core   +1 more source

SAFE software and FED database to uncover protein-protein interactions using gene fusion analysis [PDF]

, 2011
Domain Fusion Analysis takes advantage of the fact that certain proteins in a given proteome A, are found to have statistically significant similarity with two separate proteins in another proteome B.
Tsagrasoulis, Dimosthenis, Danos, Vasilis, Kissa, Maria, Trimpalis, Philip, Koumandou, Lila V., Karagouni, Amalia D., Tsakalidis, Athanasios, Kossida, Sophia   +7 more
core   +1 more source

Neural and metabolic dysregulation in PMM2-deficient human in vitro neural models

Cell Reports
Summary: Phosphomannomutase 2-congenital disorder of glycosylation (PMM2-CDG) is a rare inborn error of metabolism caused by deficiency of the PMM2 enzyme, which leads to impaired protein glycosylation.
Silvia Radenkovic, Rohit Budhraja, Teun Klein-Gunnewiek, Alexia Tyler King, Tarun N. Bhatia, Anna N. Ligezka, Karen Driesen, Rameen Shah, Bart Ghesquière, Akhilesh Pandey, Nael Nadif Kasri, Steven A. Sloan, Eva Morava, Tamas Kozicz   +13 more
doaj   +1 more source