Macular hypoplasia in congenital disorder of glycosylation type 1a [PDF]
, 2012 Congenital disorders of glycosylation are a rare group of metabolic disorders that can result in multiorgan disease. This article describes a novel finding of macular hypoplasia in congenital disorders of glycosylation type ...
Siriwardana, Pradeep +2 more
core +3 more sources
Proteomic analysis of Daphnia magna hints at molecular pathways involved in defensive plastic responses [PDF]
, 2014 Background: Phenotypic plasticity in defensive traits occurs in many species when facing heterogeneous predator regimes. The waterflea Daphnia is well-known for showing a variety of these so called inducible defences.
Arnold, Georg J. +3 more
core +5 more sources
Trypanosoma cruzi phosphomannomutase and guanosine diphosphate-mannose pyrophosphorylase ligandability assessment [PDF]
, 2019 Chagas’ disease, which is caused by the Trypanosoma cruzi parasite, has become a global health problem that is currently treated with poorly tolerated drugs that require prolonged dosing.
De Rycker, Manu +5 more
core +3 more sources
The first peptides: the evolutionary transition between prebiotic amino acids and early proteins [PDF]
, 2009 The issues we attempt to tackle here are what the first peptides did look like when they emerged on the primitive earth, and what simple catalytic activities they fulfilled.
Buhrman, Harry +4 more
core +6 more sources
Whole-genome sequence analysis of Bombella intestini LMG 28161T, a novel acetic acid bacterium isolated from the crop of a red-tailed bumble bee, Bombus lapidarius [PDF]
, 2016 The whole-genome sequence of Bombella intestini LMG 28161(T), an endosymbiotic acetic acid bacterium (AAB) occurring in bumble bees, was determined to investigate the molecular mechanisms underlying its metabolic capabilities.
Borremans, Wim +7 more
core +8 more sources
Accessing the genomic information of unculturable oceanic picoeukaryotes by combining multiple single cells [PDF]
, 2017 Mangot, Jean-François et al.-- 12 pages, 7 figures, 2 tables, supplementary information https://dx.doi.org/10.1038/srep41498Pico-sized eukaryotes play key roles in the functioning of marine ecosystems, but we still have a limited knowledge on their ...
Latorre, Fran +4 more
core +1 more source
Evidence for substrate assisted catalysis in N-acetylphosphoglucosamine mutase [PDF]
, 2018 11 pags, 4 figs, 2 tabs . -- Supplementary data is available at the Publisher's web pageN-acetylphosphoglucosamine mutase (AGM1) is a key component of the hexosamine biosynthetic pathway that produces UDP-GlcNAc, an essential precursor for a wide range ...
Baxter +36 more
core +4 more sources
Lipopolysaccharide-Deficient Brucella Variants Arise Spontaneously during Infection [PDF]
, 2011 Lipopolysaccharide-deficient mutants of smooth Brucella species (rough mutants) have been shown to arise spontaneously in culture. However, in situ analysis of Brucella infected macrophages using antibody directed against O-polysaccharide suggested a ...
Joshua E. Turse +2 more
core +2 more sources
Oil degradation and biosurfactant production by the deep sea bacterium Dietzia maris As-13-3 [PDF]
, 2014 : Recent investigations of extreme environments have revealed numerous bioactive natural products. However, biosurfactant-producing strains from deep sea extreme environment are largely unknown. Here, we show that Dietzia maris As-13-3 isolated from deep
Bobo Cai, Wanpeng Wang, Zongze Shao
core +6 more sources
Orphanet Journal of Rare Diseases, 2021 A recent report on long-term dietary mannose supplementation in phosphomannomutase 2 deficiency (PMM2-CDG) claimed improved glycosylation and called for double-blind randomized study of the dietary supplement in PMM2-CDG patients.
Peter Witters +8 more
doaj +1 more source