Results 41 to 50 of about 763 (113)

Identification of genomic regions associated with partial resistance to Aphanomyces root rot in pea

The Plant Genome, Volume 18, Issue 4, December 2025.
Abstract Root rot caused by Aphanomyces euteiches is a major concern in pea (Pisum sativum L.). The lack of other effective control strategies makes crucial the development of resistant varieties. Although partial resistance has been reported, its quantitative inheritance, the association of resistance‐linked genomic regions with unfavorable agronomic ...
Sara Rodriguez‐Mena, Maria Carlota Vaz Patto, Susana Trindade Leitão, Diego Rubiales, Mario González   +4 more
wiley   +1 more source

Unveiling Host Interactions and Evolutionary Constraints of a Novel Bacteriophage Infecting Xanthomonas hortorum pv. vitians

Environmental Microbiology Reports, Volume 17, Issue 6, December 2025.
A transposon insertion sequencing approach revealed that the novel phage ΦXhv‐1 targets Xanthomonas hortorum pv. vitians through LPS O‐antigen recognition. Mutations in LPS conferring phage resistance reduce bacterial motility and virulence, highlighting a trade‐off that may naturally constrain resistance development and support the sustainable phage ...
Anaelle Baud, Lucas Morinière, Imane El Idrissi, Fernando Clavijo‐Coppens, Elise Lacroix, Nicolas Taveau, Denis Costechareyre, Franck Bertolla   +7 more
wiley   +1 more source

A comprehensive update of genotype–phenotype correlations in PMM2-CDG: insights from molecular and structural analyses

Orphanet Journal of Rare Diseases
PMM2-CDG (phosphomannomutase 2-deficiency) is the most prevalent N-glycosylation disorder and results from impairments of PMM2 activity. This disease presents a large variety of pathogenic variants, which cause a wide phenotypical spectrum.
Tiago Oliveira, Ricardo Ferraz, Luísa Azevedo, Dulce Quelhas, João Carneiro, Jaak Jaeken, Sérgio F. Sousa   +6 more
doaj   +1 more source

Optimizing (Bio) Catalysis with Liquid‐Liquid Phase Separation Systems

ChemSystemsChem, Volume 7, Issue 6, November 2025.
This review highlights how LLPS creates membraneless compartments involved in different scenarios in nature. It further explores different examples that focus on the development of synthetic coacervates that enhance catalytic efficiency by concentrating reactants, or by the direct influence of the coacervates building blocks themselves.
David Q. P. Reis, Joana Calvário, Inês Chibeles, Mohit Kumar, Ana S. Pina   +4 more
wiley   +1 more source

Attenuated Strains of Pseudomonas aeruginosa: A Promising Cell Factory for Rhamnolipid Production

Microbial Biotechnology, Volume 18, Issue 11, November 2025.
PGN strains are generated by the deletion of virulence factor genes. The metabolic pathways and regulatory frameworks that lead to high‐efficiency production of rhamnolipids in P. aeruginosa are preserved in these strains. Therefore, PGN strains are promising bio‐safe cell factories for the industrial production of rhamnolipids.
Parvathy V. Das, Meagan E. Valentine, Timothy E. Long, Hongwei D. Yu   +3 more
wiley   +1 more source

D‐Mannose Alleviates Type 2 Diabetes and Rescues Multi‐Organ Deteriorations by Controlling Release of Pathological Extracellular Vesicles

Exploration, Volume 5, Issue 5, October 2025.
In this study, Zhang and colleagues show that drinking‐water supplementation of D‐mannose serves as an effective and potential therapeutic of type 2 diabetes, with improvement of both liver health and bone mass. The effect is exerted through suppressing macrophage release of extracellular vesicles based on metabolic control of CD36 expression.
Sha Zhang, Kai Zhang, Chen‐Xi Zheng, Ying‐Feng Gao, Guo‐Rong Deng, Xu Zhang, Yuan Yuan, Ting Jia, Si‐Yuan Tang, Guang‐Xiang He, Zhen Gong, Na Zhao, Bo Ma, Hua Tian, Hong Zhang, Zhe Li, Yong‐Chang Di‐Wu, Yi‐Han Liu, Liang Kong, Jing Ma, Yan Jin, Bing‐Dong Sui   +21 more
wiley   +1 more source

Genomic Characterization of Pan‐Drug Resistant Klebsiella pneumoniae KPNW Isolated From UTI Patient in Bangladesh

MicrobiologyOpen, Volume 14, Issue 5, October 2025.
Klebsiella pneumoniae isolate KPNW showed resistance to all clinically relevant antibiotics. Upon whole genome sequencing and characterization, we detected a large number of antimicrobial resistance genes, resistance‐associated point mutations, virulence determinants, heavy metal resistance genes, and mobile genetic elements in errorits genome ...
Md. Wahid Murad, G. M. Shah Poran, Kalpana Baidya, Nazmul Ahsan   +3 more
wiley   +1 more source

Unveiling Novel Arginase Inhibitors for Cutaneous Leishmaniasis Using Drug Repurposing and Virtual Screening Approaches

Journal of Cellular Biochemistry, Volume 126, Issue 8, August 2025.
ABSTRACT Leishmaniasis is a neglected tropical disease with a significant global health burden, particularly in developing countries, where it accounts for approximately 1.6 million new infections annually. Current therapeutic options are limited by severe adverse effects, toxicity, and drug resistance, highlighting the urgent need for novel treatment ...
Eduarda Moreira Barreto, Gabriel Rodrigues Coutinho Pereira, Isadora de Salles Arêas, Júlia Mendes Fortes, Alessandra da Silva Domingos, Lucio Mendes Cabral, Carlos Rangel Rodrigues, Alessandra Mendonça Teles de Souza, Barbara de Azevedo Abrahim‐Vieira   +8 more
wiley   +1 more source

Combined enhancement of ascorbic acid, β‐carotene and zeaxanthin in gene‐edited lettuce

Plant Biotechnology Journal, Volume 23, Issue 6, Page 1954-1967, June 2025.
Summary Lettuce is widely grown and consumed but provides lower nutritional value compared to other leafy greens, particularly in the essential vitamins A and C. To address this, major control points in carotenoid and ascorbic acid (AsA) production were targeted using a viral‐based CRISPR/Cas9 system in the commercial lettuce cultivar ‘Noga’.
Yarin Livneh, Ehud Leor‐Librach, Dor Agmon, Tal Makov‐Bouaniche, Vivekanand Tiwari, Ekaterina Shor, Yelena Yeselson, Tania Masci, Arthur Schaffer, Dana Charuvi, Joseph Hirschberg, Alexander Vainstein   +11 more
wiley   +1 more source

PtrVINV2 is dispensable for cellulose synthesis but essential for salt tolerance in Populus trichocarpa Torr. and Gray

Plant Biotechnology Journal, Volume 23, Issue 6, Page 1892-1908, June 2025.
Summary Invertase (EC.3.2.1.26), a key enzyme in sucrose breakdown, is crucial for cellulose synthesis. However, the function of the vacuolar invertase (VINV) in woody plants remains unclear. In this study, transgenic lines of Populus trichocarpa Torr. and Gray were generated to investigate the role of PtrVINV2 in wood formation and under high salinity
Shuang Zhang, Lina Cao, Danyang Chen, Ruhui Chang, Jiayu Cao, Qiaoyi Zhang, Yeling Qin, Guanjun Liu, Zhiru Xu   +8 more
wiley   +1 more source