Results 31 to 40 of about 2,733 (110)

Genome‐wide association analysis and linkage mapping decipher the genetic control of primary metabolites and quality traits in Capsicum

The Plant Journal, Volume 122, Issue 6, June 2025.
SUMMARY Pepper (Capsicum spp.) is a rich source of natural compounds, including primary metabolites essential for plants and influencing human nutrition and taste perception. Although pepper represents an important horticultural crop, the genetic bases underlying the primary metabolism remain largely unclear. Here, we performed a complementary approach
Julia von Steimker, Regina Wendenburg, Annabella Klemmer, Macellaro Rosaria, Alisdair R. Fernie, Saleh Alseekh, Pasquale Tripodi   +6 more
wiley   +1 more source

Study on the changes and significance of serum NSE, S-100B and GFAP in immature rat model of epileptic seizure

Chinese Journal of Contemporary Neurology and Neurosurgery, 2015
Objective To observe the dynamic changes of neuron-specific enolase (NSE), S-100B protein (S-100B) and glial fibrillary acidic protein (GFAP) in the serum of immature epileptic rat model, so as to explore the significance of these biochemical indexes
Qin LIU, Ji-hong TANG, Bing-bing ZHANG, Yu-xia ZHU   +3 more
doaj  

Advances in the Study of Metabolic Reprogramming in Gastric Cancer

Cancer Medicine, Volume 14, Issue 10, May 2025.
ABSTRACT Background Gastric cancer is one of the most prevalent malignancies of the digestive system and is associated with a poor prognosis, particularly in advanced metastatic stages, where the 5‐year survival rate is significantly low. Methods Recent research has demonstrated that metabolic reprogramming—including alterations in glucose, lipid, and ...
Yu Rong, Yuanyin Teng, Xiaoying Zhou
wiley   +1 more source

Metabolic growth differences between Gymnocypris przewalskii and Gymnocypris eckloni: A quantitative proteomic perspective

Journal of the World Aquaculture Society, Volume 56, Issue 2, April 2025.
Abstract Metabolism plays a crucial role in the growth rate of species. Proteomics serves as a potent tool to explore these metabolic changes. Herein, we investigated the metabolic growth differences in Gymnocypris przewalskii (GP) and Gymnocypris ecklon (GE). After 9 months of culture, the growth rate of GP was slower than that of GE (p < 0.05), while
Junming Zhou, Yun Zhao
wiley   +1 more source

Preventing epileptogenesis by interaction between inositol isomers and proteins

Epilepsia Open, Volume 10, Issue 1, Page 120-133, February 2025.
Abstract Objective Inositols play significant roles in biological systems. Myo‐inositol (MI), the most prevalent isomer, functions as an osmolyte and mediates cell signal transduction. Other notable isomers include Scyllo‐inositol (SCI) and D‐Chiro‐inositol (DCHI).
Lia Tsverava, Luka Kharkhelauri, Vincenzo Lagani, Giorgi Gamkrelidze, Veriko Bokuchava, Tamar Kiguradze, Merab Kokaia, Revaz Solomonia   +7 more
wiley   +1 more source

Transcriptomic and Metabolomic Insights Into the Prebiotic Potential of Camellia Seed Oil for Enhancing Akkermansia muciniphila Proliferation In Vitro

Food Science &Nutrition, Volume 13, Issue 1, January 2025.
Camellia seed oil is rich in bioactive compounds, which could promote the in vitro proliferation of Akkermansia muciniphila by reducing the oxidation–reduction potential of the media and activating the metabolism pathways involving energy and nucleic acid metabolism, protein synthesis, and environmental adaptation, thereby facilitating the nutrient ...
Xi Chen, Yong Zhu, Muhammad Mazhar, Likang Qin   +3 more
wiley   +1 more source

Aberrant Energy Metabolism in Tumors and Potential Therapeutic Targets

Genes, Chromosomes and Cancer, Volume 63, Issue 11, November 2024.
ABSTRACT Energy metabolic reprogramming is frequently observed during tumor progression as tumor cells necessitate adequate energy production for rapid proliferation. Although current medical research shows promising prospects in studying the characteristics of tumor energy metabolism and developing anti‐tumor drugs targeting energy metabolism, there ...
Shuhao Fan, Jianhua Guo, Hui Nie, Huabao Xiong, Yong Xia   +4 more
wiley   +1 more source

Production‐optimized fermentation of antifungal compounds by Bacillus velezensis LZN01 and transcriptome analysis

Microbial Biotechnology, Volume 17, Issue 10, October 2024.
The yields of antimicrobial compounds, such as surfactin, fengycin, shikimic acid, and myriocin, increased or were observed in the optimized fermentation CFS. In conclusion, fermentation conditions improved the antifungal activity of the LZN01 strain and influenced the expression of genes involved in the synthesis of antimicrobial compounds.
Jiale Hu, Zhigang Wang, Weihui Xu
wiley   +1 more source

Biomarcadores na encefalopatia séptica: revisão sistemática dos estudos clínicos Biomarkers in septic encephalopathy: a systematic review of clinical studies

Revista Brasileira de Terapia Intensiva, 2013
OBJETIVO: O objetivo deste estudo foi revisar sistematicamente a importância da enolase específica neuronal e S100B para diagnóstico e monitorização da encefalopatia séptica.
Paula Veriato Zenaide, Dimitri Gusmao-Flores   +1 more
doaj  

From Proteome Mining to Structural Validation: Phosphopyruvate Hydratase as a Structurally Tractable Drug Target in Kinetoplastid Parasites

Abstract Chagas disease, caused by Trypanosoma cruzi , demands novel therapeutic strategies that overcome the toxicity and limited efficacy of current treatments. To address this need, herein we report an integrative, target-centric strategy that combines parasite proteome mining ...
Luis Daniel Goyzueta-Mamani, Haruna Luz Barazorda-Ccahuana, Michelle G. Ng, Laura Pineda, José L. Medina-Franco, Mónica Florin-Christensen, Eduardo Antonio Ferraz Coelho, Carmenza Spadafora, Miguel Angel Chávez-Fumagalli   +8 more
openaire   +1 more source