Results 61 to 70 of about 2,736 (189)

Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer

Cell Reports, 2018
Summary: Application of advanced intravital imaging facilitates dynamic monitoring of pathway activity upon therapeutic inhibition. Here, we assess resistance to therapeutic inhibition of the PI3K pathway within the hypoxic microenvironment of pancreatic
James R.W. Conway, Sean C. Warren, David Herrmann, Kendelle J. Murphy, Aurélie S. Cazet, Claire Vennin, Robert F. Shearer, Monica J. Killen, Astrid Magenau, Pauline Mélénec, Mark Pinese, Max Nobis, Anaiis Zaratzian, Alice Boulghourjian, Andrew M. Da Silva, Gonzalo del Monte-Nieto, Arne S.A. Adam, Richard P. Harvey, Jody J. Haigh, Yingxiao Wang, David R. Croucher, Owen J. Sansom, Marina Pajic, C. Elizabeth Caldon, Jennifer P. Morton, Paul Timpson   +25 more
doaj   +1 more source

Water‐Enabled Ultralong Full‐Color Organic Phosphorescence in Hydrogen‐Bonded Frameworks for 4D Encryption and Bio‐Imaging

Advanced Science, EarlyView.
Water‐induced quenching challenges organic RTP materials, but a counter‐intuitive strategy employs HOF to encapsulate carbonyl guests, where water functions as a structural reinforcer. This achieves water‐enhanced ultralong RTP with full‐color emission (blue to deep red), overcoming intracellular quenching for high‐signal cellular imaging, alongside 4D
Pengcheng Wu, Zenggang Lin, Lu Yang, Weisheng Liu   +3 more
wiley   +1 more source

Bypassing Pre‐Photoactivation in High‐Barrier Polyamide for Robust and Scalable Organic Persistent Luminescence

Advanced Science, EarlyView.
A universal paradigm resolves the trade‐off between ambient stability and barrier properties in organic persistent luminescent (OPL) polymers. By interlocking chromophores within a high‐barrier MXD6 matrix, we achieved no Pre‐photoactivation OPLs with exceptional long‐term stability in water.
Yunlong Yang, Sha Liu, Shilin Bo, Longming Jin, Baijun Tang, Zhiying Guo, Chengtao Gao, Xionggang Wang, Yuejun Liu, Qiang Zheng, Zi Liang Wu   +10 more
wiley   +1 more source

D–A Type Perylene Micelles With Synergistic Charge/Energy Transfer for Dual‐Path ROS Generation and Enhanced Photocatalysis

Advanced Science, EarlyView.
Dual‐state activation of singlet and triplet excitons is achieved in perylene‐based nanomicelles via donor engineering. By synergistically pairing charge transfer with energy transfer pathways, while concurrently enabling pollutant pre‐enrichment, this strategy establishes spatial coupling between efficient ROS generation and rapid mineralization ...
Chenfan Xie, Jin Gao, Guan Wang, Xinyue Huang, Xinyi Hu, Lijun Zhu, Liujun Yang, Hua Li, Jianmei Lu   +8 more
wiley   +1 more source

Tunable Reversible Photochromic Ultralong Organic Phosphorescence via a Universal Phenylpyridine Noncovalent Assembly Strategy

Advanced Science, EarlyView.
A concise supramolecular assembly strategy using α‐cyclodextrin and phenylpyridine derivatives affords dual‐functional materials with switchable multicolor photochromism and tunable ultralong organic phosphorescence, offering new platforms for various photonic applications. ABSTRACT Supramolecular photochromic materials capable of reversible alteration
Xue Bai, Renliang Wang, Hong‐Jin Xue, Zhuofan Jiang, Shuo Yang, Chiming Li, Yanqing Ge, Caihong Liu, Xian‐Yin Dai   +8 more
wiley   +1 more source

Dual‐Network Restriction in Dense EDTA‐Metal Coordination Polymers for Highly Efficient and Stable Organic RTP in Aqueous System

Aggregate
Organic room‐temperature phosphorescence (RTP) materials are promising for bioimaging applications due to their tunable structures, excellent biocompatibility, and long‐lived luminescence.
Xin Zheng, Yongling Liu, Suhua Jiang, Jinyun Zhao, Peiyuan Wang, Yuanshan Huang, Zhenghuan Lin   +6 more
doaj   +1 more source

Room-Temperature Phosphorescent Organic-Doped Inorganic Frameworks Showing Wide-Range and Multicolor Long-Persistent Luminescence

Research, 2021
Long-persistent luminescence based on purely inorganic and/or organic compounds has recently attracted much attention in a wide variety of fields including illumination, biological imaging, and information safety.
Guowei Xiao, Bo Zhou, Xiaoyu Fang, Dongpeng Yan   +3 more
doaj   +1 more source

Isomeric Ag14 Nanoclusters With Distinct Photophysical and Nanomechanical Properties

Advanced Science, EarlyView.
Ligand‐shell isomerism in atomically precise Ag14 nanoclusters is demonstrated to regulate core distortion, photoluminescence, and mechanical properties. Subtle changes in phosphine ligand arrangement drive a pronounced emission shift from green to red and alter crystal rigidity, revealing a direct structure‐property correlation that offers new design ...
Vivek Yadav, Arijit Jana, Maya Khatun, Harshita Nagar, Sergei Lebedkin, Amit Mondal, Swetashree Acharya, Sami Malola, Sudhadevi Antharjanam, Moses Egor, Pijush Ghosh, Tomas Base, Manfred Kappes, Hannu Häkkinen, Thalappil Pradeep   +14 more
wiley   +1 more source

A deeper understanding of intestinal organoid metabolism revealed by combining fluorescence lifetime imaging microscopy (FLIM) and extracellular flux analyses

Redox Biology, 2020
Stem cells and the niche in which they reside feature a complex microenvironment with tightly regulated homeostasis, cell-cell interactions and dynamic regulation of metabolism.
Irina A. Okkelman, Nuno Neto, Dmitri B. Papkovsky, Michael G. Monaghan, Ruslan I. Dmitriev   +4 more
doaj   +1 more source

Atherosclerosis is associated with a decrease in cerebral microvascular blood flow and tissue oxygenation.

PLoS ONE, 2019
Chronic atherosclerosis may cause cerebral hypoperfusion and inadequate brain oxygenation, contributing to the progression of cognitive decline. In this study, we exploited two-photon phosphorescence lifetime microscopy to measure the absolute partial ...
Baoqiang Li, Xuecong Lu, Mohammad Moeini, Sava Sakadžić, Eric Thorin, Frederic Lesage   +5 more
doaj   +1 more source