Results 1 to 10 of about 6,663 (162)

Multiphoton Phosphorescence Quenching Microscopy Reveals Kinetics of Tumor Oxygenation during Antiangiogenesis and Angiotensin Signaling Inhibition. [PDF]

Clin Cancer Res, 2022
Abstract Purpose: The abnormal function of tumor blood vessels causes tissue hypoxia, promoting disease progression and treatment resistance. Although tumor microenvironment normalization strategies can alleviate hypoxia globally, how local oxygen levels change is not known because of the ...
Martin JD, Lanning RM, Chauhan VP, Martin MR, Mousa AS, Kamoun WS, Han HS, Lee H, Stylianopoulos T, Bawendi MG, Duda DG, Brown EB, Padera TP, Fukumura D, Jain RK.   +14 more
europepmc   +3 more sources

Towards Water Soluble Mitochondria-Targeting Theranostic Osmium(II) Triazole-Based Complexes [PDF]

Molecules, 2016
The complex [Os(btzpy)2][PF6]2 (1, btzpy = 2,6-bis(1-phenyl-1,2,3-triazol-4-yl)pyridine) has been prepared and characterised. Complex 1 exhibits phosphorescence (λem = 595 nm, τ = 937 ns, φem = 9.3% in degassed acetonitrile) in contrast to its known ...
Salem A. E. Omar, Paul A. Scattergood, Luke K. McKenzie, Helen E. Bryant, Julia A. Weinstein, Paul I. P. Elliott   +5 more
doaj   +5 more sources

Gavage approach to oxygen supplementation with oxygen therapeutic Ox66™ in a hypoventilation rodent model of respiratory distress

Artificial Cells, Nanomedicine, and Biotechnology, 2021
Acute respiratory distress syndrome (ARDS) features pulmonary dysfunction capable of causing life-threatening hypoxaemia. Ventilation and hyperoxic therapies force oxygen through dysfunctional alveoli but risk exacerbating damage. Ox66™ is an ingestible,
William H. Nugent, Danuel A. Carr, Rosa MacBryde, Erica D. Bruce, Bjorn K. Song   +4 more
doaj   +1 more source

Dynamics of PO2 and VO2 in resting and contracting rat spinotrapezius muscle

Frontiers in Physiology, 2023
This study examined changes in interstitial PO2, which allowed calculation of VO2 during periods of rest, muscle contraction and recovery using an in situ rat spinotrapezius muscle preparation.
Aleksander S. Golub, Aleksander S. Golub, Bjorn K. Song, Bjorn K. Song, William H. Nugent, William H. Nugent, Roland N. Pittman   +6 more
doaj   +1 more source

Systemic and microvascular comparison of Lactated Ringer’s solution, VIR-HBOC, and alpha-alpha crosslinked haemoglobin-based oxygen carrier in a rat 10% topload model

Artificial Cells, Nanomedicine, and Biotechnology, 2020
Medical support for traumatic haemorrhage is lacking for far-forward combat units. VIR-HBOC (haemoglobin-based oxygen carrier) is a novel biological therapeutic under development as a field-stable resuscitation fluid.
Bjorn K. Song, W. Richard Light, Kim D. Vandegriff, Joe Tucker, William H. Nugent   +4 more
doaj   +1 more source

Amplified singlet oxygen generation in metallated-porphyrin doped conjugated polymer nanoparticles [PDF]

, 2018
We report on the mechanism and efficiencies of singlet oxygen O2(1Δg) generation of nanoparticles (NP) of the conjugated polymer (CP) poly(9,9-dioctylfluorene-alt-benzothiadiazole) (F8BT) doped with platinum octaethylporphyrin (PtOEP) suspended in water.
Chesta, Carlos Alberto, Hernández, Laura, Ibarra, Luis Exequiel, Lorente, Carolina, Macor, Lorena Paola, Palacios, Rodrigo Emiliano, Ponzio, Rodrigo Andrés, Spada, Ramiro Martín   +7 more
core   +2 more sources

Microvascular and systemic responses to novel PEGylated carboxyhaemoglobin-based oxygen carrier in a rat model of vaso-occlusive crisis

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Hypoxia drives sickle cell disease (SCD) by inducing sickle cell haemoglobin to polymerize and deform red blood cells (RBC) into the sickle shape.
William H. Nugent, Ronald Jubin, Peter J. Buontempo, Friedericke Kazo, Bjorn K. Song   +4 more
doaj   +1 more source

Structure of the Cytoplasmic Loop between Putative Helices II and III of the Mannitol Permease of Escherichia coli: A Tryptophan and 5-Fluorotryptophan Spectroscopy Study [PDF]

, 2008
In this work, four single tryptophan (Trp) mutants of the dimeric mannitol transporter of Escherichia coli, EIImtl, are characterized using Trp and 5-fluoroTrp (5-FTrp) fluorescence spectroscopy.
Broos J., Broos J., Broos J., Broos J., Broos J., Callis P. R., Chen Y., Cioni P., Eftink M. R., Galley W. C., Gonnelli M., Gonnelli M., Koning R. I., Lakowicz J. R., Legler P. M., Lengeler J. W., Liu T. Q., Meech S. R., Nguyen T. X., Robillard G. T., Robillard G. T., Ross J. B. A., Strambini G. B., Sugiyama J. E., Swaving Dijkstra D., van Montfort B. A., van Montfort R. L. M., Veldhuis G., Veldhuis G., Veldhuis G., Vervoort E. B., Vos E. P., Winkler G. R.   +32 more
core   +3 more sources

Data from Multiphoton Phosphorescence Quenching Microscopy Reveals Kinetics of Tumor Oxygenation during Antiangiogenesis and Angiotensin Signaling Inhibition

, 2023
<div>AbstractPurpose:<p>The abnormal function of tumor blood vessels causes tissue hypoxia, promoting disease progression and treatment resistance. Although tumor microenvironment normalization strategies can alleviate hypoxia globally, how local oxygen levels change is not known because of the inability to longitudinally assess vascular ...
Rakesh K. Jain, Dai Fukumura, Timothy P. Padera, Edward B. Brown, Dan G. Duda, Moungi G. Bawendi, Triantafyllos Stylianopoulos, Hang Lee, Hee-Sun Han, Walid S. Kamoun, Ahmed S. Mousa, Margaret R. Martin, Vikash P. Chauhan, Ryan M. Lanning, John D. Martin   +14 more
openaire   +1 more source

Supplementary Data from Multiphoton Phosphorescence Quenching Microscopy Reveals Kinetics of Tumor Oxygenation during Antiangiogenesis and Angiotensin Signaling Inhibition

, 2023
Supplementary Data from Multiphoton Phosphorescence Quenching Microscopy Reveals Kinetics of Tumor Oxygenation during Antiangiogenesis and Angiotensin Signaling ...
Rakesh K. Jain, Dai Fukumura, Timothy P. Padera, Edward B. Brown, Dan G. Duda, Moungi G. Bawendi, Triantafyllos Stylianopoulos, Hang Lee, Hee-Sun Han, Walid S. Kamoun, Ahmed S. Mousa, Margaret R. Martin, Vikash P. Chauhan, Ryan M. Lanning, John D. Martin   +14 more
openaire   +1 more source