Results 1 to 10 of about 1,922 (120)

Multiphoton Phosphorescence Quenching Microscopy Reveals Kinetics of Tumor Oxygenation during Antiangiogenesis and Angiotensin Signaling Inhibition. [PDF]

Clin Cancer Res, 2022
Abstract Purpose: The abnormal function of tumor blood vessels causes tissue hypoxia, promoting disease progression and treatment resistance. Although tumor microenvironment normalization strategies can alleviate hypoxia globally, how local oxygen levels change is not known because of the ...
Martin JD, Lanning RM, Chauhan VP, Martin MR, Mousa AS, Kamoun WS, Han HS, Lee H, Stylianopoulos T, Bawendi MG, Duda DG, Brown EB, Padera TP, Fukumura D, Jain RK.   +14 more
europepmc   +3 more sources

A mathematical model of tissue axial and radial diffusion in the microvasculature for intravascular microscopy and phosphorescence quenching data

Computers in Biology and Medicine
This study aims to extend earlier Krogh Cylinder Models of an oxygen profile by considering axial diffusion and analytically solving Fick's Law Partial Differential Equation with novel boundary conditions via the separation of variables. We next prospectively collected a total of 20 animals, which were randomly assigned to receive either fresh or two ...
Vinay P Jani, Vivek Jani
exaly   +5 more sources

Circularly Polarized Luminescent and Melt-Processable Copper(I)-Organic Glasses Based on 2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl. [PDF]

Angew Chem Int Ed Engl
Homochiral Cu(I) cyanide complexes based on 2,2’‐bis(diphenylphosphino)‐1,1’‐binaphthyl (BINAP) form melt‐quenched and desolvation‐derived metal–organic glasses that exhibit circularly polarized thermally activated delayed fluorescence (TADF) at room temperature, enabling processable chiroptical materials.
Fan Z, Sen I, Pallach R, Li GQ, Steffen A, Henke S.   +5 more
europepmc   +3 more sources

Gavage approach to oxygen supplementation with oxygen therapeutic Ox66™ in a hypoventilation rodent model of respiratory distress

Artificial Cells, Nanomedicine, and Biotechnology, 2021
Acute respiratory distress syndrome (ARDS) features pulmonary dysfunction capable of causing life-threatening hypoxaemia. Ventilation and hyperoxic therapies force oxygen through dysfunctional alveoli but risk exacerbating damage. Ox66™ is an ingestible,
William H. Nugent, Danuel A. Carr, Rosa MacBryde, Erica D. Bruce, Bjorn K. Song   +4 more
doaj   +1 more source

Dynamics of PO2 and VO2 in resting and contracting rat spinotrapezius muscle

Frontiers in Physiology, 2023
This study examined changes in interstitial PO2, which allowed calculation of VO2 during periods of rest, muscle contraction and recovery using an in situ rat spinotrapezius muscle preparation.
Aleksander S. Golub, Aleksander S. Golub, Bjorn K. Song, Bjorn K. Song, William H. Nugent, William H. Nugent, Roland N. Pittman   +6 more
doaj   +1 more source

Systemic and microvascular comparison of Lactated Ringer’s solution, VIR-HBOC, and alpha-alpha crosslinked haemoglobin-based oxygen carrier in a rat 10% topload model

Artificial Cells, Nanomedicine, and Biotechnology, 2020
Medical support for traumatic haemorrhage is lacking for far-forward combat units. VIR-HBOC (haemoglobin-based oxygen carrier) is a novel biological therapeutic under development as a field-stable resuscitation fluid.
Bjorn K. Song, W. Richard Light, Kim D. Vandegriff, Joe Tucker, William H. Nugent   +4 more
doaj   +1 more source

Microvascular and systemic responses to novel PEGylated carboxyhaemoglobin-based oxygen carrier in a rat model of vaso-occlusive crisis

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Hypoxia drives sickle cell disease (SCD) by inducing sickle cell haemoglobin to polymerize and deform red blood cells (RBC) into the sickle shape.
William H. Nugent, Ronald Jubin, Peter J. Buontempo, Friedericke Kazo, Bjorn K. Song   +4 more
doaj   +1 more source

Data from Multiphoton Phosphorescence Quenching Microscopy Reveals Kinetics of Tumor Oxygenation during Antiangiogenesis and Angiotensin Signaling Inhibition

, 2023
<div>AbstractPurpose:<p>The abnormal function of tumor blood vessels causes tissue hypoxia, promoting disease progression and treatment resistance. Although tumor microenvironment normalization strategies can alleviate hypoxia globally, how local oxygen levels change is not known because of the inability to longitudinally assess vascular ...
Rakesh K. Jain, Dai Fukumura, Timothy P. Padera, Edward B. Brown, Dan G. Duda, Moungi G. Bawendi, Triantafyllos Stylianopoulos, Hang Lee, Hee-Sun Han, Walid S. Kamoun, Ahmed S. Mousa, Margaret R. Martin, Vikash P. Chauhan, Ryan M. Lanning, John D. Martin   +14 more
openaire   +1 more source

Towards Water Soluble Mitochondria-Targeting Theranostic Osmium(II) Triazole-Based Complexes

Molecules, 2016
The complex [Os(btzpy)2][PF6]2 (1, btzpy = 2,6-bis(1-phenyl-1,2,3-triazol-4-yl)pyridine) has been prepared and characterised. Complex 1 exhibits phosphorescence (λem = 595 nm, τ = 937 ns, φem = 9.3% in degassed acetonitrile) in contrast to its known ...
Salem A. E. Omar, Paul A. Scattergood, Luke K. McKenzie, Helen E. Bryant, Julia A. Weinstein, Paul I. P. Elliott   +5 more
doaj   +1 more source

Supplementary Data from Multiphoton Phosphorescence Quenching Microscopy Reveals Kinetics of Tumor Oxygenation during Antiangiogenesis and Angiotensin Signaling Inhibition

, 2023
Supplementary Data from Multiphoton Phosphorescence Quenching Microscopy Reveals Kinetics of Tumor Oxygenation during Antiangiogenesis and Angiotensin Signaling ...
Rakesh K. Jain, Dai Fukumura, Timothy P. Padera, Edward B. Brown, Dan G. Duda, Moungi G. Bawendi, Triantafyllos Stylianopoulos, Hang Lee, Hee-Sun Han, Walid S. Kamoun, Ahmed S. Mousa, Margaret R. Martin, Vikash P. Chauhan, Ryan M. Lanning, John D. Martin   +14 more
openaire   +1 more source