Results 1 to 10 of about 2,006 (77)

Gavage approach to oxygen supplementation with oxygen therapeutic Ox66™ in a hypoventilation rodent model of respiratory distress

Artificial Cells, Nanomedicine, and Biotechnology, 2021
Acute respiratory distress syndrome (ARDS) features pulmonary dysfunction capable of causing life-threatening hypoxaemia. Ventilation and hyperoxic therapies force oxygen through dysfunctional alveoli but risk exacerbating damage. Ox66™ is an ingestible,
William H. Nugent, Danuel A. Carr, Rosa MacBryde, Erica D. Bruce, Bjorn K. Song   +4 more
doaj   +1 more source

Dynamics of PO2 and VO2 in resting and contracting rat spinotrapezius muscle

Frontiers in Physiology, 2023
This study examined changes in interstitial PO2, which allowed calculation of VO2 during periods of rest, muscle contraction and recovery using an in situ rat spinotrapezius muscle preparation.
Aleksander S. Golub, Aleksander S. Golub, Bjorn K. Song, Bjorn K. Song, William H. Nugent, William H. Nugent, Roland N. Pittman   +6 more
doaj   +1 more source

Systemic and microvascular comparison of Lactated Ringer’s solution, VIR-HBOC, and alpha-alpha crosslinked haemoglobin-based oxygen carrier in a rat 10% topload model

Artificial Cells, Nanomedicine, and Biotechnology, 2020
Medical support for traumatic haemorrhage is lacking for far-forward combat units. VIR-HBOC (haemoglobin-based oxygen carrier) is a novel biological therapeutic under development as a field-stable resuscitation fluid.
Bjorn K. Song, W. Richard Light, Kim D. Vandegriff, Joe Tucker, William H. Nugent   +4 more
doaj   +1 more source

Microvascular and systemic responses to novel PEGylated carboxyhaemoglobin-based oxygen carrier in a rat model of vaso-occlusive crisis

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Hypoxia drives sickle cell disease (SCD) by inducing sickle cell haemoglobin to polymerize and deform red blood cells (RBC) into the sickle shape.
William H. Nugent, Ronald Jubin, Peter J. Buontempo, Friedericke Kazo, Bjorn K. Song   +4 more
doaj   +1 more source

Towards Water Soluble Mitochondria-Targeting Theranostic Osmium(II) Triazole-Based Complexes

Molecules, 2016
The complex [Os(btzpy)2][PF6]2 (1, btzpy = 2,6-bis(1-phenyl-1,2,3-triazol-4-yl)pyridine) has been prepared and characterised. Complex 1 exhibits phosphorescence (λem = 595 nm, τ = 937 ns, φem = 9.3% in degassed acetonitrile) in contrast to its known ...
Salem A. E. Omar, Paul A. Scattergood, Luke K. McKenzie, Helen E. Bryant, Julia A. Weinstein, Paul I. P. Elliott   +5 more
doaj   +1 more source

Oxygenation through oral Ox66 in a two-hit rodent model of respiratory distress

Artificial Cells, Nanomedicine, and Biotechnology
Acute respiratory distress syndrome (ARDS) is a complication of pulmonary disease that produces life-threatening hypoxaemia. Despite ventilation and hyperoxic therapies, undetected hypoxia can manifest in capillary beds leading to multi-organ failure ...
Bjorn K. Song, Danuel A. Carr, Erica D. Bruce, William H. Nugent   +3 more
doaj   +1 more source

Rationalizing the Unexpected Inefficiencies of 3D Porphyrin‐MOFs as Singlet Oxygen Photosensitizers Against Botrytis cinerea

Advanced Materials Interfaces
Porphyrin‐based MOFs (PMOFs) are known to be efficient photocatalysts and singlet oxygen (1O2) photosensitizers (PS) in solution, but their application in agriculture and food protection is practically unknown.
Océane Boudreau, Paul Asselin, Seyed Mehrzad Sajjadinezhad, Paul‐Ludovic Karsenti, Peter Moffett, Kamal Bouarab, Pierre D. Harvey   +6 more
doaj   +1 more source

Multiphoton Phosphorescence Quenching Microscopy Reveals Kinetics of Tumor Oxygenation during Antiangiogenesis and Angiotensin Signaling Inhibition. [PDF]

Clin Cancer Res, 2022
Martin JD, Lanning RM, Chauhan VP, Martin MR, Mousa AS, Kamoun WS, Han HS, Lee H, Stylianopoulos T, Bawendi MG, Duda DG, Brown EB, Padera TP, Fukumura D, Jain RK.   +14 more
europepmc   +1 more source

Oxygels: Tunable Phosphorescent Hydrogels for Cherenkov-Excited Luminescence Imaging (CELI) of Oxygen. [PDF]

Adv Healthc Mater
Belali S, Mendoza MIO, Reed MS, Mykhalchuk D, Lang A, Boerckel JD, Pogue BW, Vinogradov SA.   +7 more
europepmc   +1 more source

Metabolism and oxygen tension in Alzheimer's disease mouse model using two-photon FLIM-PLIM microscopy. [PDF]

Neurophotonics
Sagar VK, Wallrabe H, Alam SR, Pardo E, Becker W, Norambuena A, Periasamy A.   +6 more
europepmc   +1 more source