Results 1 to 10 of about 1,891 (87)

Multiphoton Phosphorescence Quenching Microscopy Reveals Kinetics of Tumor Oxygenation during Antiangiogenesis and Angiotensin Signaling Inhibition [PDF]

Clinical Cancer Research, 2022
Abstract Purpose: The abnormal function of tumor blood vessels causes tissue hypoxia, promoting disease progression and treatment resistance. Although tumor microenvironment normalization strategies can alleviate hypoxia globally, how local oxygen levels change is not known because of the ...
, , Timothy Padera
exaly   +4 more sources

Gavage approach to oxygen supplementation with oxygen therapeutic Ox66™ in a hypoventilation rodent model of respiratory distress

Artificial Cells, Nanomedicine, and Biotechnology, 2021
Acute respiratory distress syndrome (ARDS) features pulmonary dysfunction capable of causing life-threatening hypoxaemia. Ventilation and hyperoxic therapies force oxygen through dysfunctional alveoli but risk exacerbating damage. Ox66™ is an ingestible,
William H. Nugent, Danuel A. Carr, Rosa MacBryde, Erica D. Bruce, Bjorn K. Song   +4 more
doaj   +1 more source

Dynamics of PO2 and VO2 in resting and contracting rat spinotrapezius muscle

Frontiers in Physiology, 2023
This study examined changes in interstitial PO2, which allowed calculation of VO2 during periods of rest, muscle contraction and recovery using an in situ rat spinotrapezius muscle preparation.
Aleksander S. Golub, Aleksander S. Golub, Bjorn K. Song, Bjorn K. Song, William H. Nugent, William H. Nugent, Roland N. Pittman   +6 more
doaj   +1 more source

Systemic and microvascular comparison of Lactated Ringer’s solution, VIR-HBOC, and alpha-alpha crosslinked haemoglobin-based oxygen carrier in a rat 10% topload model

Artificial Cells, Nanomedicine, and Biotechnology, 2020
Medical support for traumatic haemorrhage is lacking for far-forward combat units. VIR-HBOC (haemoglobin-based oxygen carrier) is a novel biological therapeutic under development as a field-stable resuscitation fluid.
Bjorn K. Song, W. Richard Light, Kim D. Vandegriff, Joe Tucker, William H. Nugent   +4 more
doaj   +1 more source

Data from Multiphoton Phosphorescence Quenching Microscopy Reveals Kinetics of Tumor Oxygenation during Antiangiogenesis and Angiotensin Signaling Inhibition

, 2023
<div>AbstractPurpose:<p>The abnormal function of tumor blood vessels causes tissue hypoxia, promoting disease progression and treatment resistance. Although tumor microenvironment normalization strategies can alleviate hypoxia globally, how local oxygen levels change is not known because of the inability to longitudinally assess vascular ...
Rakesh K. Jain, Dai Fukumura, Timothy P. Padera, Edward B. Brown, Dan G. Duda, Moungi G. Bawendi, Triantafyllos Stylianopoulos, Hang Lee, Hee-Sun Han, Walid S. Kamoun, Ahmed S. Mousa, Margaret R. Martin, Vikash P. Chauhan, Ryan M. Lanning, John D. Martin   +14 more
openaire   +1 more source

Microvascular and systemic responses to novel PEGylated carboxyhaemoglobin-based oxygen carrier in a rat model of vaso-occlusive crisis

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Hypoxia drives sickle cell disease (SCD) by inducing sickle cell haemoglobin to polymerize and deform red blood cells (RBC) into the sickle shape.
William H. Nugent, Ronald Jubin, Peter J. Buontempo, Friedericke Kazo, Bjorn K. Song   +4 more
doaj   +1 more source

Towards Water Soluble Mitochondria-Targeting Theranostic Osmium(II) Triazole-Based Complexes

Molecules, 2016
The complex [Os(btzpy)2][PF6]2 (1, btzpy = 2,6-bis(1-phenyl-1,2,3-triazol-4-yl)pyridine) has been prepared and characterised. Complex 1 exhibits phosphorescence (λem = 595 nm, τ = 937 ns, φem = 9.3% in degassed acetonitrile) in contrast to its known ...
Salem A. E. Omar, Paul A. Scattergood, Luke K. McKenzie, Helen E. Bryant, Julia A. Weinstein, Paul I. P. Elliott   +5 more
doaj   +1 more source

Supplementary Data from Multiphoton Phosphorescence Quenching Microscopy Reveals Kinetics of Tumor Oxygenation during Antiangiogenesis and Angiotensin Signaling Inhibition

, 2023
Supplementary Data from Multiphoton Phosphorescence Quenching Microscopy Reveals Kinetics of Tumor Oxygenation during Antiangiogenesis and Angiotensin Signaling ...
Rakesh K. Jain, Dai Fukumura, Timothy P. Padera, Edward B. Brown, Dan G. Duda, Moungi G. Bawendi, Triantafyllos Stylianopoulos, Hang Lee, Hee-Sun Han, Walid S. Kamoun, Ahmed S. Mousa, Margaret R. Martin, Vikash P. Chauhan, Ryan M. Lanning, John D. Martin   +14 more
openaire   +1 more source

Rate of oxygen disappearance from arterioles in rat mesentery measured with scanning phosphorescence quenching microscopy (PQM)

The FASEB Journal, 2010
The oxygen disappearance curve (ODC) recorded in an arteriole after rapid arrest of blood flow reflects the complex interaction between the HbO 2 dissociation curve and the kinetics of tissue respiration.
Aleksander Sergeevich Golub, Bjorn Kyungsuck Song, Roland Natan Pittman   +2 more
openaire   +1 more source

Impact of accumulated oxygen depletion (AOD) on measurements of oxygen tension (PO2) using phosphorescence quenching microscopy (PQM)

The FASEB Journal, 2008
PQM is a powerful method to measure PO 2 in microvessels. However, its application to stationary tissue and fluids has never been substantiated. Multiple flash excitations applied in PQM to the same sampled volume produce AOD and distort the measured PO 2
Aleksander Sergeevich Golub, Roland Nathan Pittman   +1 more
openaire   +1 more source