Results 11 to 20 of about 43,490 (186)

Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation

Nature Communications, 2019
The enzyme nicotinate phosphoribosyltransferase (NAPRT) mediates the rate-limiting step in NAD salvage pathway starting from nicotinic acid. Here the authors show that NAPRT can be detected extracellularly, binds to Toll like receptor 4, and activates NF-
Antonella Managò, Valentina Audrito, Francesca Mazzola, Leonardo Sorci, Federica Gaudino, Katiuscia Gizzi, Nicoletta Vitale, Danny Incarnato, Gabriele Minazzato, Alice Ianniello, Antonio Varriale, Sabato D’Auria, Giulio Mengozzi, Gianfranco Politano, Salvatore Oliviero, Nadia Raffaelli, Silvia Deaglio   +16 more
doaj   +2 more sources

Crystal structure of human nicotinic acid phosphoribosyltransferase

FEBS Open Bio, 2015
Nicotinic acid phosphoribosyltransferase (EC 2.4.2.11) (NaPRTase) is the rate‐limiting enzyme in the three‐step Preiss–Handler pathway for the biosynthesis of NAD.
Ada Serena Marletta, Alberto Massarotti, Giuseppe Orsomando, Giulio Magni, Menico Rizzi, Silvia Garavaglia   +5 more
doaj   +2 more sources

Purification and identification of metabolites produced by Bacillus cereus and B. subtilis active against Meloidogyne exigua, and their in silico interaction with a putative phosphoribosyltransferase fromM. incognita

Anais da Academia Brasileira de Ciências, 2014
To contribute to the development of products to controlMeloidogyne exigua, the bacteria Bacillus cereus and B. subtilis were cultivated in liquid medium to produce metabolites active against this plant-parasitic nematode.
DENILSON F. OLIVEIRA, HELVÉCIO M. DOS SANTOS JÚNIOR, ALEXANDRO S. NUNES, VICENTE P. CAMPOS, RENATA S.C. DE PINHO, GIOVANNA C. GAJO   +5 more
doaj   +2 more sources

Nicotinamide Phosphoribosyltransferase Acts as a Metabolic Gate for Mobilization of Myeloid-Derived Suppressor Cells [PDF]

Cancer Research, 2019
Cancer induces alteration of hematopoiesis to fuel disease progression. We report that in tumor-bearing mice the macrophage colony-stimulating factor elevates the myeloid cell levels of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting ...
Cristina Travelli, Francesca Maria Consonni, Sabina Sangaletti, Mariangela Storto, Sara Morlacchi, Ambra A. Grolla, Ubaldina Galli, Gian Cesare Tron, Paola Portararo, Lorenza Rimassa, Tiziana Pressiani, Massimiliano Mazzone, Rosalinda Trovato, Stefano Ugel, Vincenzo Bronte, Claudio Tripodo, Mario P. Colombo, Armando A. Genazzani, Antonio Sica   +18 more
openalex   +2 more sources

Targeting metabolic reprogramming in metastatic melanoma: The key role of nicotinamide phosphoribosyltransferase (NAMPT)

Seminars in Cell and Developmental Biology, 2019
Valentina Audrito, Antonella Managò, Federica Gaudino, Silvia Deaglio   +3 more
openalex   +3 more sources

Extracellular nicotinamide phosphoribosyltransferase: role in disease pathophysiology and as a biomarker

Frontiers in Immunology, 2023
Nicotinamide phosphoribosyltransferase (NAMPT) plays a central role in mammalian cell metabolism by contributing to nicotinamide adenine dinucleotide biosynthesis. However, NAMPT activity is not limited to the intracellular compartment, as once secreted,
Elise Semerena, A. Nencioni, K. Masternak   +2 more
semanticscholar   +1 more source

Nicotinamide Phosphoribosyltransferase as a Key Molecule of the Aging/Senescence Process

International Journal of Molecular Sciences, 2021
Aging is a phenomenon underlined by complex molecular and biochemical changes that occur over time. One of the metabolites that is gaining strong research interest is nicotinamide adenine dinucleotide, NAD+, whose cellular level has been shown to ...
F. D. Khaidizar, Yasumasa Bessho, Yasukazu Nakahata   +2 more
semanticscholar   +1 more source

Adenine phosphoribosyltransferase deficiency

Definitions, 2020
Affected individuals can develop features of this condition anytime from infancy to late adulthood. When the condition appears in infancy, the first sign is usually the presence of tiny grains of reddish-brown material in the baby's diaper caused by the ...
G. Bollée
semanticscholar   +1 more source

Metabolomics Analysis of Metabolic Effects of Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibition on Human Cancer Cells

PLoS ONE, 2014
Nicotinamide phosphoribosyltransferase (NAMPT) plays an important role in cellular bioenergetics. It is responsible for converting nicotinamide to nicotinamide adenine dinucleotide, an essential molecule in cellular metabolism. NAMPT has been extensively
Vladimir Tolstikov, Alexander Nikolayev, Sucai Dong, Genshi Zhao, Ming‐Shang Kuo   +4 more
openalex   +3 more sources

The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells

Haematologica, 2012
Background Inhibitors of nicotinamide phosphoribosyltransferase have recently been validated as therapeutic targets in leukemia, but the mechanism of leukemogenic transformation downstream of this enzyme is unclear.Design and Methods Here, we evaluated ...
Lan Dan, Olga Klimenkova, Maxim Klimiankou, Jan-Henning Klusman, Marry M. van den Heuvel-Eibrink, Dirk Reinhardt, Karl Welte, Julia Skokowa   +7 more
doaj   +1 more source