Results 11 to 20 of about 37,163 (226)
Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression
Hepatology, EarlyView., 2022 Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández +18 more
wiley +1 more source
Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy
Hepatology, EarlyView., 2022 Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann +25 more
wiley +1 more source
Crystalline Quinolinate Phosphoribosyltransferase
Journal of Biological Chemistry, 1965 Abstract Quinolinate phosphoribosyltransferase catalyzes the formation of nicotinic acid mononucleotide, carbon dioxide, and inorganic pyrophosphate from quinolinic acid and 5-phosphoribosyl 1-pyrophosphate. The enzyme has a molecular weight of 165,000 and can be irreversibly dissociated into inactive protein units with a molecular weight of 54,000 ...
P M, Packman, W B, Jakoby
openaire +2 more sources
Haematologica, 2012 Background Inhibitors of nicotinamide phosphoribosyltransferase have recently been validated as therapeutic targets in leukemia, but the mechanism of leukemogenic transformation downstream of this enzyme is unclear.Design and Methods Here, we evaluated ...
Lan Dan +7 more
doaj +1 more source
Nature Communications, 2022 NAD + metabolism is potential target to treat metabolic disorders, in part due to the effects of the NAD + dependent enzyme Sirt1. Here the authors report that hepatic nicotinamide phosphoribosyltransferase, a rate-limiting step in the NAD + salvage ...
Cassandra B. Higgins +6 more
doaj +1 more source
PRTFDC1 is a genetic modifier of HPRT-deficiency in the mouse. [PDF]
PLoS ONE, 2011 Lesch-Nyhan disease (LND) is a severe X-linked neurological disorder caused by a deficiency of hypoxanthine phosphoribosyltransferase (HPRT). In contrast, HPRT-deficiency in the mouse does not result in the profound phenotypes such as self-injurious ...
Alaine C Keebaugh +6 more
doaj +1 more source
Global Medical Genetics, 2021 Visfatin is an adipocytokine and a potential biomarker encoded by the nicotinamide phosphoribosyltransferase gene. It belongs to the nicotinic acid phosphoribosyltransferase family and involved in various metabolic processes and aging.
Amita Coutinho +3 more
doaj +1 more source
NAMPT and NAPRT: Two Metabolic Enzymes With Key Roles in Inflammation
Frontiers in Oncology, 2020 Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate phosphoribosyltransferase (NAPRT) are two intracellular enzymes that catalyze the first step in the biosynthesis of NAD from nicotinamide and nicotinic acid, respectively.
Valentina Audrito +2 more
doaj +1 more source
PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma
Nature Communications, 2019 Mutations in the Protein Phosphatase PPM1D are oncogenic in certain cancers including diffuse intrinsic pontine glioma (DIPG). Here, the authors show that PPM1D mutations in DIPG induce the silencing of the nicotinic acid phosphoribosyltransferase gene ...
Nathan R. Fons +14 more
doaj +1 more source
Biochemical characterization of uracil phosphoribosyltransferase from Mycobacterium tuberculosis. [PDF]
PLoS ONE, 2013 Uracil phosphoribosyltransferase (UPRT) catalyzes the conversion of uracil and 5-phosphoribosyl-α-1-pyrophosphate (PRPP) to uridine 5'-monophosphate (UMP) and pyrophosphate (PP(i)). UPRT plays an important role in the pyrimidine salvage pathway since UMP
Anne Drumond Villela +8 more
doaj +1 more source