Results 31 to 40 of about 55,635 (283)

Efficacy of laser capture microdissection plus RT-PCR technique in analyzing gene expression levels in human gastric cancer and colon cancer

BMC Cancer, 2008
Background Thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, and orotate phosphoribosyltransferase gene expressions are reported to be valid predictive markers for 5-fluorouracil sensitivity to gastrointestinal cancer.
Danenberg Peter V, Danenberg Kathleen, Uetake Hiroyuki, Makino Hiroshi, Sugihara Kenichi   +4 more
doaj   +1 more source

In Vivo Biotinylation of the Toxoplasma Parasitophorous Vacuole Reveals Novel Dense Granule Proteins Important for Parasite Growth and Pathogenesis. [PDF]

, 2016
UnlabelledToxoplasma gondii is an obligate intracellular parasite that invades host cells and replicates within a unique parasitophorous vacuole. To maintain this intracellular niche, the parasite secretes an array of dense granule proteins (GRAs) into ...
Bell, Hannah N, Bradley, Peter J, Coppens, Isabelle, Kim, Elliot W, Lin, Andrew H, Nadipuram, Santhosh M, Vashisht, Ajay A, Wohlschlegel, James A   +7 more
core   +2 more sources

Rare forms of nephrolithiasis

Pediatria i Medycyna Rodzinna, 2019
Inborn errors of metabolism that may lead to calculus formation within the urinary tract include: adenine phosphoribosyltransferase deficiency, xanthine oxidase deficiency, orotic aciduria (acidosis) type I and alkaptonuria.
Piotr Skrzypczyk, Małgorzata Pańczyk-Tomaszewska   +1 more
doaj   +1 more source

Thermophilic phosphoribosyltransferases Thermus thermophilus HB27 in nucleotide synthesis

Beilstein Journal of Organic Chemistry, 2018
Phosphoribosyltransferases are the tools that allow the synthesis of nucleotide analogues using multi-enzymatic cascades. The recombinant adenine phosphoribosyltransferase (TthAPRT) and hypoxanthine phosphoribosyltransferase (TthHPRT) from Thermus ...
Ilja V. Fateev, Ekaterina V. Sinitsina, Aiguzel U. Bikanasova, Maria A. Kostromina, Elena S. Tuzova, Larisa V. Esipova, Tatiana I. Muravyova, Alexei L. Kayushin, Irina D. Konstantinova, Roman S. Esipov   +9 more
doaj   +1 more source

Discovery of potential visfatin activators using in silico docking and ADME predictions as therapy for type 2 diabetes

Beni-Suef University Journal of Basic and Applied Sciences, 2018
Visfatin (Nicotinamide phosphoribosyltransferase) is an adipokine implicated in mediating insulin resistance and exhibiting insulin mimetic effect and therefore represents a druggable target for diabetes therapy.
Olusola Olalekan Elekofehinti, Oluwamodupe Cecilia Ejelonu, Jean Paul Kamdem, Oluwaseun Benedicta Akinlosotu, Ayodeji Famuti, Damilare Desmond Adebowale, Opeyemi Iwaloye, Yetunde Irinyemi Bulu, Ige Joseph Kade, Joao Batista Teixeira Rocha   +9 more
doaj   +1 more source

Normal Uricemia in Lesch–Nyhan Syndrome and the Association with Pulmonary Embolism in a Young Child—A Case Report and Literature Review

Pediatrics and Neonatology, 2014
Deficiency of hypoxanthine phosphoribosyltransferase activity is a rare inborn error of purine metabolism with subsequent uric acid overproduction and neurologic presentations.
Jeng-Dau Tsai, Shan-Ming Chen, Chien-Heng Lin, Min-Sho Ku, Teng-Fu Tsao, Ji-Nan Sheu   +5 more
doaj   +1 more source

Apt (Adenine Phosphoribosyltransferase) Mutation in Laboratory-Selected Vancomycin-Intermediate Staphylococcus aureus

Antibiotics, 2021
Comparative genomic sequencing of laboratory-derived vancomycin-intermediate Staphylococcusaureus (VISA) (MM66-3 and MM66-4) revealed unique mutations in both MM66-3 (in apt and ssaA6), and MM66-4 (in apt and walK), compared to hetero-VISA parent strain ...
Reena Lamichhane-Khadka, Santosh Dulal, Jesus A. Cuaron, Richard Pfeltz, Sushim Kumar Gupta, Brian J. Wilkinson, John E. Gustafson   +6 more
doaj   +1 more source

Trithiacyanuric acid: a second triclinic polymorph [PDF]

, 2010
The title compound, C3H3N3S3, is a triclinic modification. The other reported modification crystallizes with just one molecule in the asymmetric unit, [Guo et al. (2006). Cryst. Growth Des.
Brito, Iván, Albanez, Joselyn, Bolte, Michael   +2 more
core   +2 more sources

Curcumin affects HSP60 folding activity and levels in neuroblastoma cells [PDF]

, 2020
The fundamental challenge in fighting cancer is the development of protective agents able to interfere with the classical pathways of malignant transformation, such as extracellular matrix remodeling, epithelial\u2013mesenchymal transition and ...
Campanella C., Cappello F., CARUSO BAVISOTTO C., Lo Cascio F., Marino Gammazza A., Mocciaro E., Pace A., Palumbo Piccionello A., Vergilio G., Vitale A.M.   +9 more
core   +2 more sources

A Versatile Continuous Fluorometric Enzymatic Assay for Targeting Nicotinate Phosphoribosyltransferase

Molecules, 2023
The maintenance of a proper NAD+ pool is essential for cell survival, and tumor cells are particularly sensitive to changes in coenzyme levels. In this view, the inhibition of NAD+ biosynthesis is considered a promising therapeutic approach.
Gabriele Minazzato, Elisa Marangoni, Carlo Fortunato, Riccardo Petrelli, Loredana Cappellacci, Fabio Del Bello, Leonardo Sorci, Massimiliano Gasparrini, Francesco Piacente, Santina Bruzzone, Nadia Raffaelli   +10 more
doaj   +1 more source