Results 11 to 20 of about 55,635 (283)
Anticancer Activities of Novel Nicotinamide Phosphoribosyltransferase Inhibitors in Hematological Malignancies [PDF]
Molecules, 2023 Targeting cancer cells that are highly dependent on the nicotinamide adenine dinucleotide (NAD+) metabolite is a promising therapeutic strategy. Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme catalyzing NAD+ production ...
Paulina Biniecka +16 more
doaj +2 more sources
Hypoxanthine-Guanine Phosphoribosyltransferase [PDF]
, 2020 National Cancer Institute
openaire +2 more sources
It takes two to tango: NAD+ and sirtuins in aging/longevity control [PDF]
, 2016 The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD+ and sirtuins has an ancient origin and provides a ...
Guarente, Leonard, Imai, Shin-ichiro
core +2 more sources
Pyrroloquinoline quinone increases the expression and activity of Sirt1 and -3 genes in HepG2 cells. [PDF]
, 2015 Sirtuin (Sirt) 1 and Sirt 3 are nicotinamide adenine dinucleotide ((+))-dependent protein deacetylases that are important to a number of mitochondrial-related functions; thus, identification of sirtuin activators is important. Herein, we hypothesize that
Arguelles, Andrix +6 more
core +1 more source
Crystalline Quinolinate Phosphoribosyltransferase
Journal of Biological Chemistry, 1965 Abstract Quinolinate phosphoribosyltransferase catalyzes the formation of nicotinic acid mononucleotide, carbon dioxide, and inorganic pyrophosphate from quinolinic acid and 5-phosphoribosyl 1-pyrophosphate. The enzyme has a molecular weight of 165,000 and can be irreversibly dissociated into inactive protein units with a molecular weight of 54,000 ...
P M, Packman, W B, Jakoby
openaire +2 more sources
Haematologica, 2012 Background Inhibitors of nicotinamide phosphoribosyltransferase have recently been validated as therapeutic targets in leukemia, but the mechanism of leukemogenic transformation downstream of this enzyme is unclear.Design and Methods Here, we evaluated ...
Lan Dan +7 more
doaj +1 more source
Nature Communications, 2022 NAD + metabolism is potential target to treat metabolic disorders, in part due to the effects of the NAD + dependent enzyme Sirt1. Here the authors report that hepatic nicotinamide phosphoribosyltransferase, a rate-limiting step in the NAD + salvage ...
Cassandra B. Higgins +6 more
doaj +1 more source
Absolute quantification of the host-to-parasite DNA ratio in Theileria parva-infected lymphocyte cell lines [PDF]
, 2016 Theileria parva is a tick-transmitted intracellular apicomplexan pathogen of cattle in sub-Saharan Africa that causes East Coast fever (ECF). ECF is an acute fatal disease that kills over one million cattle annually, imposing a tremendous burden on ...
Bishop, Richard P. +5 more
core +4 more sources
Identification of Fis1 Interactors in Toxoplasma gondii Reveals a Novel Protein Required for Peripheral Distribution of the Mitochondrion [PDF]
, 2020 Toxoplasma gondii’s single mitochondrion is very dynamic and undergoes morphological changes throughout the parasite’s life cycle. During parasite division, the mitochondrion elongates, enters the daughter cells just prior to cytokinesis, and undergoes ...
Arrizabalaga, Gustavo +2 more
core +1 more source
PRTFDC1 is a genetic modifier of HPRT-deficiency in the mouse. [PDF]
PLoS ONE, 2011 Lesch-Nyhan disease (LND) is a severe X-linked neurological disorder caused by a deficiency of hypoxanthine phosphoribosyltransferase (HPRT). In contrast, HPRT-deficiency in the mouse does not result in the profound phenotypes such as self-injurious ...
Alaine C Keebaugh +6 more
doaj +1 more source