Results 211 to 220 of about 26,651 (230)
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Crystal Structure of Orotate Phosphoribosyltransferase
Biochemistry, 1994Phosphoribosyltransferases (PRTases) are enzymes involved in the synthesis of purine, pyrimidine, and pyridine nucleotides. They utilize alpha-D-5-phosphoribosyl-1-pyrophosphate (PRPP) and a nitrogenous base to form a beta-N-riboside monophosphate and pyrophosphate (PPi), and their functional significance in nucleotide homeostasis is evidenced by the ...
Giovanna Scapin +2 more
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[77] Adenine phosphoribosyltransferase
1978Publisher Summary This chapter describes the assay method of adenine phosphoribosyltransferase (APRT) enzyme. Human APRT catalyzes the magnesium-dependent transfer of the ribose-5-phosphate moiety of 5-phosphoribosyl-l-pyrophosphate (PP-ribose-P) to the 9 position of the purine base adenine to form adenosine-5'-monophosphate (AMP).
William J. Arnold, William N. Kelley
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1978
Publisher Summary This chapter describes the methodology of hypoxanthine phosphoribosyltransferase and guanine phosphoribosyltransferase enzyme purification from enteric bacteria. Phosphoribosyltransferases (PRTs) for hypoxanthine and guanine are separate activities representing the gene products of only distantly linked genes on the chromosome of ...
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Publisher Summary This chapter describes the methodology of hypoxanthine phosphoribosyltransferase and guanine phosphoribosyltransferase enzyme purification from enteric bacteria. Phosphoribosyltransferases (PRTs) for hypoxanthine and guanine are separate activities representing the gene products of only distantly linked genes on the chromosome of ...
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Adenine phosphoribosyltransferase deficiency in children
Pediatric Nephrology, 2012Adenine phosphoribosyltransferase (APRT) deficiency is a rare autosomal recessive disorder characterized by 2,8-dihydroxyadenine (2,8-DHA) crystalluria that can cause nephrolithiasis and chronic kidney disease. The aim of our study was to assess the clinical presentation, diagnosis, and outcome of APRT deficiency in a large pediatric cohort.
Jérôme Harambat +4 more
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APMIS, 2011
Olesen UH, Hastrup N, Sehested M. Expression patterns of nicotinamide phosphoribosyltransferase and nicotinic acid phosphoribosyltransferase in human malignant lymphomas. APMIS 2011; 119: 296–303.The purpose of the study was to determine in human malignant lymphomas the expression patterns of nicotinamide phosphoribosyltransferase (NAMPT) and nicotinic
Olesen, Uffe Høgh +2 more
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Olesen UH, Hastrup N, Sehested M. Expression patterns of nicotinamide phosphoribosyltransferase and nicotinic acid phosphoribosyltransferase in human malignant lymphomas. APMIS 2011; 119: 296–303.The purpose of the study was to determine in human malignant lymphomas the expression patterns of nicotinamide phosphoribosyltransferase (NAMPT) and nicotinic
Olesen, Uffe Høgh +2 more
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Molecular and Biochemical Parasitology, 1989
The adenine phosphoribosyltransferase (APRTase) and hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) activities from promastigotes of Leishmania donovani have been purified to homogeneity using ammonium sulfate precipitation, DEAE-cellulose exclusion, and either AMP-agarose (APRTase) or GTP-agarose (HGPRTase) affinity chromatography.
Laura Cross +5 more
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The adenine phosphoribosyltransferase (APRTase) and hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) activities from promastigotes of Leishmania donovani have been purified to homogeneity using ammonium sulfate precipitation, DEAE-cellulose exclusion, and either AMP-agarose (APRTase) or GTP-agarose (HGPRTase) affinity chromatography.
Laura Cross +5 more
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The Spectrum of Hypoxanthine-guanine Phosphoribosyltransferase Deficiency
QJM: An International Journal of Medicine, 1973The spectrum of clinical manifestations of hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) deficiency is presented by reference to eight patients from five kindred. These patients illustrate the range of associated neurological findings, together with the variety of presentation and complications due to the associated over-production of urate.
Emmerson, B. T., Thompson, L.
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Quinolinic Acid Phosphoribosyltransferase in Rat Brain
Journal of Neurochemistry, 1985Abstract: Because of the possible participation of quinolinic acid in brain function and/or dysfunction, the characteristics of its catabolic enzyme, quinolinic acid phosphoribosyltransferase (QPRTase; EC 2.4.2.19), were examined in rat brain tissue. For this purpose, a sensitive radiochemical assay method, based on the conversion of quinolinic acid ...
Alan C. Foster +2 more
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Inheritance of Adenine Phosphoribosyltransferase (APRT) Deficiency [PDF]
, 1980 Recognition of the importance of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT) in the control of purine metabolism lead to systematic investigations of the companion purine salvage enzyme, adenine phosphoribosyltransferase (APRT). This was followed by the discovery of individuals (considered to be heterozygous for the defect) with ...
K. J. Van Acker +7 more
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Mouse models of hypoxanthine phosphoribosyltransferase deficiency
Journal of Inherited Metabolic Disease, 1992SummaryLesch‐Nyhan syndrome is an X‐linked disease caused by the deficiency of hypoxanthine phosphoribosyltransferase, an enzyme involved in the purine salvage pathways. It is characterized by severe gout, choreoathetosis, self‐mutilatory behaviour and mental retardation. The derivation of mice genetically deficient in this enzyme may help to elucidate
M. L. Hooper +2 more
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