Results 41 to 50 of about 43,490 (186)

Apt (Adenine Phosphoribosyltransferase) Mutation in Laboratory-Selected Vancomycin-Intermediate Staphylococcus aureus

Antibiotics, 2021
Comparative genomic sequencing of laboratory-derived vancomycin-intermediate Staphylococcusaureus (VISA) (MM66-3 and MM66-4) revealed unique mutations in both MM66-3 (in apt and ssaA6), and MM66-4 (in apt and walK), compared to hetero-VISA parent strain ...
Reena Lamichhane-Khadka, Santosh Dulal, Jesus A. Cuaron, Richard Pfeltz, Sushim Kumar Gupta, Brian J. Wilkinson, John E. Gustafson   +6 more
doaj   +1 more source

Recurrent 2,8-Dihydroxyadenine Crystalline Nephropathy in Renal Allograft

Annals of Internal Medicine: Clinical Cases
Adenine phosphoribosyltransferase deficiency is a rare cause of crystalline kidney disease. We present a case of end-stage kidney disease secondary to crystal deposition from adenine phosphoribosyltransferase deficiency with immediate recurrence of the ...
Farid Arman, Russell John Crew, Michael Barry Stokes, Jai Radhakrishnan   +3 more
doaj   +1 more source

NAD+ metabolism controls inflammation during senescence

Molecular & Cellular Oncology, 2019
We have recently discovered that nicotinamide adenine dinucleotide metabolism controls the pro-inflammatory senescence-associated secretory phenotype during cellular senescence.
Timothy Nacarelli, Rugang Zhang
doaj   +1 more source

Epigenetic regulation of Runx2 transcription and osteoblast differentiation by nicotinamide phosphoribosyltransferase

Cell & Bioscience, 2017
Bone degenerative disorders like osteoporosis may be initiated by age-related shifts in anabolic and catabolic responses that control bone homeostasis. Although there are studies suggesting that metabolic changes occur with stem cell differentiation, the
Min Ling, Peixin Huang, S. Islam, D. Heruth, Xuan'an Li, L. Zhang, Ding-You Li, Zhaohui Hu, S. Ye   +8 more
semanticscholar   +1 more source

Enhancing the anticancer effect of NAMPT inhibition by targeting NAPRT in breast cancer cells

Advances in Cancer Biology - Metastasis
Introduction: Two pathways in the synthesis of NAD, catalyzed by the key enzymes nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate phosphoribosyltransferase (NAPRT), support constant survival, growth, and propagation of cancer cells.
Zahra Gharedaghi, Parichehr Mehrafshar, Soha Mohammadi, Masoumeh Tavakoli-Yaraki, Pegah Golpour, Mitra Nourbakhsh, Nima Taghizadeh   +6 more
doaj   +1 more source

Insights into the NAD+ biosynthesis pathways involved during meiotic maturation and spindle formation in porcine oocytes

The Journal of Reproduction and Development, 2022
Treatments that elevate NAD+ levels have been found to improve oocyte quality in mice, cattle, and pigs, suggesting that NAD+ is vital during oocyte maturation.
Charley-Lea POLLARD, Ashleigh YOUNAN, Aleona SWEGEN, Zamira GIBB, Christopher G. GRUPEN   +4 more
doaj   +1 more source

Dihydroxyadenine stone with adenine phosphoribosyltransferase deficiency: A case report

Indian Journal of Urology, 2017
Adenine phosphoribosyltransferase (APRT) deficiency is a rare autosomal recessive error of purine metabolism resulting in the generation of 2,8-dihydroxyadenine (DHA), a highly insoluble metabolite of adenine, which can cause radiolucent urolithiasis ...
Pramod Krishnappa, Venkatesh Krishnamoorthy, Kiran Krishne Gowda   +2 more
doaj   +1 more source

Properly Substituted Benzimidazoles as a New Promising Class of Nicotinate Phosphoribosyltransferase (NAPRT) Modulators

Pharmaceuticals, 2023
The prevention of nicotinamide adenine dinucleotide (NAD) biosynthesis is considered an attractive therapeutic approach against cancer, considering that tumor cells are characterized by an increased need for NAD to fuel their reprogrammed metabolism.
Cecilia Baldassarri, Gianfabio Giorgioni, Alessandro Piergentili, Wilma Quaglia, Stefano Fontana, Valerio Mammoli, Gabriele Minazzato, Elisa Marangoni, Massimiliano Gasparrini, Leonardo Sorci, Nadia Raffaelli, Loredana Cappellacci, Riccardo Petrelli, Fabio Del Bello   +13 more
doaj   +1 more source

Extracellular nicotinamide phosphoribosyltransferase boosts IFNγ-induced macrophage polarization independently of TLR4

iScience, 2022
Summary: Nicotinamide phosphoribosyltransferase (NAMPT), alongside being a crucial enzyme in NAD synthesis, has been shown to be a secreted protein (eNAMPT), whose levels are increased in patients affected by immune-mediated disorders.
Giorgia Colombo, Cristina Travelli, Chiara Porta, Armando A. Genazzani   +3 more
doaj   +1 more source

Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody–Drug Conjugates

ACS Medicinal Chemistry Letters, 2018
Antibody–drug conjugates (ADCs) are a novel modality that allows targeted delivery of potent therapeutic agents to the desired site. Herein we report our discovery of NAMPT inhibitors as a novel nonantimitotic payload for ADCs.
A. Karpov, T. Abrams, Suzanna Clark, Ankita Raikar, J. A. D'alessio, M. P. Dillon, T. Gesner, Darryl Jones, M. Lacaud, W. Mallet, P. Martyniuk, E. Meredith, Morvarid Mohseni, C. Nieto-Oberhuber, Daniel S. Palacios, Francesca Perruccio, Grazia Piizzi, M. Zurini, C. U. Bialucha   +18 more
semanticscholar   +1 more source