Results 51 to 60 of about 43,490 (186)

Cancer cell metabolic plasticity allows resistance to NAMPT inhibition but invariably induces dependence on LDHA

Cancer & Metabolism, 2018
Background Inhibitors of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in NAD+ biosynthesis from nicotinamide, exhibit anticancer effects in preclinical models.
Natthakan Thongon, Chiara Zucal, Vito Giuseppe D’Agostino, Toma Tebaldi, Silvia Ravera, Federica Zamporlini, Francesco Piacente, Ruxanda Moschoi, Nadia Raffaelli, Alessandro Quattrone, Alessio Nencioni, Jean-Francois Peyron, Alessandro Provenzani   +12 more
doaj   +1 more source

N2′‐Branched Acyclic Nucleoside Phosphonates Containing 9‐Deazahypoxanthine as Inhibitors of Plasmodium falciparum 6‐Oxopurine Phosphoribosyltransferase [PDF]

, 2023
Karolína Vaňková, Dianne T. Keough, Dana Hocková, Luke W. Guddat, Zlatko Janeba   +4 more
openalex   +1 more source

Boosting NAD+ with a small molecule that activates NAMPT

Nature Communications, 2019
Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate determining step for NAD+ synthesis and is of interest as a drug target. Here the authors identify and characterize a small molecule NAMPT activator SBI-797812, elucidate its mode of ...
Stephen J. Gardell, Meghan Hopf, Asima Khan, Mauro Dispagna, E. Hampton Sessions, Rebecca Falter, Nidhi Kapoor, Jeanne Brooks, Jeffrey Culver, Chris Petucci, Chen-Ting Ma, Steven E. Cohen, Jun Tanaka, Emmanuel S. Burgos, Jennifer S. Hirschi, Steven R. Smith, Eduard Sergienko, Anthony B. Pinkerton   +17 more
doaj   +1 more source

NAMPT and NAPRT, Key Enzymes in NAD Salvage Synthesis Pathway, Are of Negative Prognostic Value in Colorectal Cancer

Frontiers in Oncology, 2019
Nicotinamide adenine dinucleotide (NAD) is a profoundly important cofactor in redox reactions. Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate phosphoribosyltransferase (NAPRT) are key enzymes for NAD salvage biosynthesis pathway, which ...
Xiao-qin Li, Jing Lei, Lin-hong Mao, Qing-liang Wang, Feng Xu, Tao Ran, Zhi-hang Zhou, Song He   +7 more
doaj   +1 more source

Nicotinamide phosphoribosyltransferase may be involved in age-related brain diseases. [PDF]

PLoS ONE, 2012
Nicotinamide phosphoribosyltransferase (NAMPT) is a key enzyme for nicotinamide adenine dinucleotide (NAD) biosynthesis, and can be found either intracellularly (iNAMPT) or extracellularly (eNAMPT).
Li-Ying Liu, Feng Wang, Xia-Yan Zhang, Peng Huang, Yun-Bi Lu, Er-Qing Wei, Wei-Ping Zhang   +6 more
doaj   +1 more source

Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors

OncoTarget, 2015
Nicotinamide adenine dinucleotide (NAD) is a cofactor in redox reactions and a substrate for NAD-consuming enzymes, such as PARPs and sirtuins. As cancer cells have increased NAD requirements, the main NAD salvage enzymes in humans, nicotinamide ...
Sara Duarte-Pereira, Isabel Pereira-Castro, S. S. Silva, M. G. Correia, Célia Neto, L. T. da Costa, António Amorim, Raquel M. Silva   +7 more
semanticscholar   +1 more source

Discovery and characterization of novel small-molecule inhibitors targeting nicotinamide phosphoribosyltransferase

Scientific Reports, 2015
Nicotinamide phosphoribosyltransferase (NAMPT) is a promising anticancer target. Using high throughput screening system targeting NAMPT, we obtained a potent NAMPT inhibitor MS0 (China Patent ZL201110447488.9) with excellent in vitro activity (IC50 = 9 ...
Tianying Xu, Sai-long Zhang, Guo-Qiang Dong, Xin-Zhu Liu, Xia Wang, Xiao-Qun Lv, Q. Qian, Ruo-Yu Zhang, Chun-Quan Sheng, Chao-yu Miao   +9 more
semanticscholar   +1 more source

A Mycobacterial Phosphoribosyltransferase Promotes Bacillary Survival by Inhibiting Oxidative Stress and Autophagy Pathways in Macrophages and Zebrafish*

Journal of Biological Chemistry, 2015
Background: Several Mycobacterium tuberculosis glycoproteins are involved in tuberculosis pathogenesis. Results: Mycobacterium tuberculosis Rv3242c and Mycobacterium marinum mimG enhance bacillary survival by inhibiting oxidative stress and autophagy ...
S. Mohanty, L. Jagannathan, G. Ganguli, A. Padhi, Debasish Roy, Nader Alaridah, Pratip Saha, U. Nongthomba, G. Godaly, R. K. Gopal, Sulagna Banerjee, A. Sonawane   +11 more
semanticscholar   +1 more source

Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity

Cell Research, 2022
Hong Yao, Minghui Liu, Leibo Wang, Yumeng Zu, Chou‐Bin Wu, Chenyu Li, Ruoxi Zhang, Haigen Lu, Feifei Li, Shuang Xi, Shuangquan Chen, Xuanyu Gu, Tianya Liu, Jie Cai, Shirong Wang, Maojun Yang, G. Xing, Wei Xiong, Lan Hua, Yefeng Tang, Gelin Wang   +20 more
semanticscholar   +1 more source

The NAD Biosynthesis Pathway Mediated by Nicotinamide Phosphoribosyltransferase Regulates Sir2 Activity in Mammalian Cells*

Journal of Biological Chemistry, 2004
Recent studies have revealed new roles for NAD and its derivatives in transcriptional regulation. The evolutionarily conserved Sir2 protein family requires NAD for its deacetylase activity and regulates a variety of biological processes, such as stress ...
Javier R. Revollo, Andrew A. Grimm, S. Imai   +2 more
semanticscholar   +1 more source