Results 91 to 100 of about 900,190 (260)

Purine nucleoside phosphorylase enables dual metabolic checkpoints that prevent T cell immunodeficiency and TLR7-associated autoimmunity

The Journal of Clinical Investigation, 2022
Purine nucleoside phosphorylase (PNP) enables the breakdown and recycling of guanine nucleosides. PNP insufficiency in humans is paradoxically associated with both immunodeficiency and autoimmunity, but the mechanistic basis for these outcomes is ...
Evan R. Abt, Khalid Rashid, Thuc M. Le, Suwen Li, Hailey R. Lee, Vincent Lok, Luyi Li, Amanda L. Creech, Amanda N. Labora, Hanna K. Mandl, Alex K. Lam, Arthur Cho, Valerie Rezek, Nanping Wu, Gabriel Abril-Rodriguez, Ethan W. Rosser, Steven D. Mittelman, Willy Hugo, Thomas Mehrling, Shanta Bantia, Antoni Ribas, Timothy R. Donahue, Gay M. Crooks, Ting-Ting Wu, Caius G. Radu   +24 more
doaj   +1 more source

Use of the enzyme hexokinase for the reduction of inherent light levels [PDF]

, 1969
Use of enzyme hexokinase and glucose to reduce inherent light levels of ATP in luciferase ...
Chappelle, E. W.
core   +1 more source

Glycogen metabolic genes are involved in trehalose-6-phosphate synthase-mediated regulation of pathogenicity by the rice blast fungus Magnaporthe oryzae. [PDF]

, 2013
© 2013 Badaruddin et al.Editor - Peter N. Dodds, Commonwealth Scientific and Industrial Research Organisation (CSIRO), AustraliaThis work was funded by the Biotechnology and Biological Sciences Research Council and a European Research Council Advanced ...
AE Stellwagen, AJ Foster, AM Carroll, B Valent, C Veneault-Fourrey, D Mayer, DB Rylatt, DG Saunders, DJ Ballance, E Thines, EH Fischer, G Giaever, GK Bhambra, HH Sillje, I Farkas, J Fernandez, JA Sweigard, JC de Jong, JD Thompson, JL Parrou, JL Parrou, JR Xu, K Adachi, K Lerch, KP Dixon, KR Oldenburg, Lucy J. Holcombe, MA Frohman, MA Teste, Michael J. Kershaw, MJ Kershaw, Muhammad Badaruddin, Nicholas J. Talbot, NJ Talbot, NL Catlett, NL Craig, P Kankanala, P Skamnioti, Peter N. Dodds, PK Hwang, PK Hwang, RA Dean, RA Wilson, RA Wilson, RA Wilson, RA Wilson, Richard A. Wilson, RJ Howard, RWS Weber, SF Altschul, SH Lillie, T Chida, TA Hardy, TK Mitchell, TM Bourett, WA Wilson, X Zhao, YZ Deng, YZ Deng, Z Gunja-Smith, Zheng-Yi Wang, ZY Wang   +61 more
core   +3 more sources

Metabolic Stress‐Induced Choline Kinase α (CHKA) Activation in Endothelial Subpopulation Contributes to Diabetes‐Associated Microvascular Dysfunction

Advanced Science, Volume 12, Issue 33, September 4, 2025.
This study uncovers CHKA as a pivotal driver of vascular dysfunction in diabetic retinopathy and highlights its role in endothelial dysfunction through NAD⁺‐SIRT1‐Notch signaling. Single‐cell and functional analyses, combined with clinical and genetic validation, suggest CHKA as a promising therapeutic target for the prevention and treatment of ...
Ling Ren, Linyu Zhang, Yun Bai, Chang Huang, Xiaosa Li, Fanfei Ma, Wan Mu, Mudi Yao, Chang Jiang, Xiangjun Chen, Qin Jiang, Biao Yan   +11 more
wiley   +1 more source

N‐ to C‐Glycoside Rearrangement of Uridine 5′‐Phosphate in Two Enzymatic Steps for the Production of Pseudouridine 5′‐Phosphate

Biotechnology and Bioengineering, Volume 122, Issue 9, Page 2456-2464, September 2025.
The authors present a streamlined cascade reaction for one‐pot N‐C rearrangement of uridine‐5′‐phosphate (UMP) to pseudouridine‐5′‐phosphate (ΨMP; a key mRNA vaccine building block), in two enzymatic steps catalyzed by UMP nucleosidase (EC 3.2.2.10) and ΨMP C‐glycosidase (EC 4.2.1.70).
Martin Pfeiffer, Franziska Guld, Bernd Nidetzky   +2 more
wiley   +1 more source

Variation in Gene Expression Across Infection Status and Elevation in a Hawaiian Honeycreeper

Ecology and Evolution, Volume 15, Issue 9, September 2025.
Introduced pathogens exert novel selection on hosts, and some hosts have adapted to highly virulent pathogens. We tested for differential gene expression between (i) avian malaria‐infected and ‐uninfected Hawai'i 'amakihi and (ii) low‐ and high‐elevation 'amakihi.
Loren Cassin‐Sackett, Katherine M. McClure, Taylor E. Callicrate, Eben H. Paxton, Robert C. Fleischer   +4 more
wiley   +1 more source

Pravastatin Protects Against Avascular Necrosis of Femoral Head via Autophagy

Frontiers in Physiology, 2018
Autophagy serves as a stress response and may contribute to the pathogenesis of avascular necrosis of the femoral head induced by steroids. Statins promote angiogenesis and ameliorate endothelial functions through apoptosis inhibition and necrosis of ...
Yun Liao, Yun Liao, Ping Zhang, Bo Yuan, Ling Li, Shisan Bao, Shisan Bao   +6 more
doaj   +1 more source

LC-MS proteomics analysis of the iInsulin/IGF-1-deficient Caenorhabditis elegans daf-2(e1370) mutant reveals extensive restructuring of intermediary metabolism [PDF]

, 2014
The insulin/IGF-1 receptor is a major known determinant of dauer formation, stress resistance, longevity, and metabolism in Caenorhabditis elegans. In the past, whole-genome transcript profiling was used extensively to study differential gene expression ...
Braeckman, Bart, Brewer, Heather M, Camp, David G, II, Depuydt, Geert, Petyuk, Vladislav A, Smith, Richard D, Smolders, Arne, Xie, Fang   +7 more
core   +2 more sources

SHBs Mitigates Sorafenib‐Induced Apoptosis in Hepatocellular Carcinoma via Activation of RAF1/MEK/ERK Signaling Pathway

Cancer Science, Volume 116, Issue 9, Page 2471-2485, September 2025.
Hepatitis B virus (HBV) infection is a major driver of hepatocellular carcinoma (HCC) and is associated with resistance to sorafenib, the first‐line treatment for advanced HCC. This study demonstrates that the small HBV surface antigen (SHBs) promotes sorafenib resistance by activating the RAF1/MEK/ERK signaling pathway, inhibiting apoptosis in HCC ...
Shuxiang Wu, Yuxiang Hong, Hang Li, Mengxian Lin, Xiaohuang Lin, Xinjian Lin, Xu Lin   +6 more
wiley   +1 more source

Regulatory Functions of Nilaparvata lugens GSK-3 in Energy and Chitin Metabolism

Frontiers in Physiology, 2020
Glucose metabolism is a biologically important metabolic process. Glycogen synthase kinase (GSK-3) is a key enzyme located in the middle of the sugar metabolism pathway that can regulate the energy metabolism process in the body through insulin signaling.
Yan-Juan Ding, Yan-Juan Ding, Guo-Yong Li, Cai-Di Xu, Yan Wu, Zhong-Shi Zhou, Shi-Gui Wang, Can Li   +7 more
doaj   +1 more source