Results 101 to 110 of about 900,190 (260)

Anticancer activity of a thymidine quinoxaline conjugate is modulated by cytosolic thymidine pathways [PDF]

, 2015
Background High levels of thymidine kinase 1 (TK1) and thymidine phosphorylase (TYMP) are key molecular targets by thymidine therapeutics in cancer treatment.
Liu, Haijuan, Wei, Qiong, Zhang, Dejun, Zhang, Zhiwei, Zhou, Honghao, Zhou, Qibing   +5 more
core   +2 more sources

Report of an Iranian child with chronic abdominal pain and constipation diagnosed as glycogen storage disease type IX: a case report

Journal of Medical Case Reports
Background Glycogen storage disease type IX is a rare disorder that can cause a wide variety of symptoms depending on the specific deficiency of the phosphorylase kinase enzyme and the organs it affects.
Daniel Zamanfar, Seyed MohammadBagher Hashemi-Soteh, Mobin Ghazaiean, Elham Keyhanian   +3 more
doaj   +1 more source

Aldehyde dehydrogenase 1A1 and gelsolin identified as novel invasion-modulating factors in conditioned medium of pancreatic cancer cells [PDF]

, 2008
Conditioned medium (CM) from clonal sub-populations of the pancreatic cancer cell line, MiaPaCa-2 with differing invasive abilities, were examined for their effect on in vitro invasion.
Alban, Albini, Altmeyer, Bendtsen, Bhave, Chaponnier, Collard, Cunningham, Dosaka-Akita, Faivre, Ferlay, Goggins, Han, Holdenrieder, Jelski, Jelski, Jemal, Koya, Kulasingam, Kumar, Kuramitsu, Kwiatkowski, Kwiatkowski, Lee, Lundin, Martin, Martin Clynes, Michael Henry, Moreb, Naomi Walsh, Negm, Ni, Norma O'Donovan, Noske, Okano, Orchekowski, Paul Dowling, Paula Meleady, Safi, Sagawa, Shieh, Sladek, Tanaka, Tanaka, Tanudji, Tempero, Thompson, Thor, Wang, Winston, Yin, Yoshida   +51 more
core   +3 more sources

Integrierte chemo‐enzymatische Synthese des mRNA‐Impfstoff‐Bausteins N1‐Methylpseudouridintriphosphat

Angewandte Chemie, Volume 137, Issue 34, August 18, 2025.
Pseudouridin‐5'‐triphosphat (ΨTP) und sein N1‐methyliertes Derivat (m1ΨTP) sind entscheidende Komponenten in der mRNA‐Impfstofftechnologie. Hier wird ein atomökonomischer, ertragreicher biokatalytischer Weg zur Synthese von ΨTP vorgestellt. Zudem wurde ein neuer chemo‐enzymatischer Weg für die m1ΨTP‐Synthese entwickelt.
Martin Pfeiffer, Leo Krammer, Johannes Zöhrer, Rolf Breinbauer, Bernd Nidetzky   +4 more
wiley   +1 more source

Tau phosphorylation at Alzheimer\u27s disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated. [PDF]

, 2016
Abnormal phosphorylation of the microtubule-associated protein tau is observed in many neurodegenerative diseases, including Alzheimer\u27s disease (AD).
Ando, Kanae, Hayashishita, Motoki, Hisanaga, Shin-Ichi, Iijima, Koichi M., Ohtake, Yosuke, Oka, Mikiko, Shimizu, Sawako   +6 more
core   +1 more source

Occurrence of high and low Mr forms of glycogen phosphorylase in extracts of human brain [PDF]

, 1981
Monthly newsletter with information of interest to University Hospital and the Boston University Medical ...
Proux, Proux, Martin, Hedrick, Hu, Titani, Seery, Johnson, Satoh, Feldmann   +9 more
core   +1 more source

Metabolic constraint of human telomere length by nucleotide salvage efficiency

Nature Communications
Human telomere length is tightly regulated and associated with diseases at either extreme, but how these bounds are established remains incompletely understood.
William Mannherz, Andrew Crompton, Noah Lampl, Suneet Agarwal   +3 more
doaj   +1 more source

Guanine nucleotide exchange factor αPIX leads to activation of the Rac 1 GTPase/glycogen phosphorylase pathway in interleukin (IL)-2-stimulated T cells [PDF]

, 2015
Recently, we have reported that the active form of Rac 1 GTPase binds to the glycogen phosphorylase muscle isoform (PYGM) and modulates its enzymatic activity leading to T cell proliferation.
Gálvez, Patricia, Lacerda, Hadriano M, Llavero, Francisco, Osinalde, Nerea, Parada, Luis A, Urzelai, Bakarne, Zugaza, José L   +6 more
core   +1 more source

Integrated Chemoenzymatic Synthesis of the mRNA Vaccine Building Block N1‐Methylpseudouridine Triphosphate

Angewandte Chemie International Edition, Volume 64, Issue 34, August 18, 2025.
Pseudouridine‐5′‐triphosphate (ΨTP) and its N1‐methylated derivative (m1ΨTP) are crucial components in mRNA vaccine technology. Here, an atom‐economic, high‐yielding biocatalytic route for ΨTP synthesis is presented. A new chemoenzymatic route for m1ΨTP synthesis was developed.
Martin Pfeiffer, Leo Krammer, Johannes Zöhrer, Rolf Breinbauer, Bernd Nidetzky   +4 more
wiley   +1 more source

Phosphoproteins and protein-kinase activity in isolated envelopes of pea (Pisum sativum L.) chloroplasts [PDF]

, 1985
A protein kinase was found in envelope membranes of purified pea (Pisum sativum L.) chloroplasts. Separation of the two envelope membranes showed that most of the enzyme activity was localized in the outer envelope.
D.G. Robinson, G. Mourioux, G.M. Hathaway, H.Y. Nakatani, J. Joyard, J. Pfisterer, J. Soll, J. Soll, K. Cline, K. Cline, M.A. Block, O.H. Lowry, R. Douce, R. Douce, T.J. Yan, U.J. Flügge, W.A. Laing, Z.F. Lin   +17 more
core   +1 more source