Results 41 to 50 of about 900,190 (260)

Methylthioadenosine phosphorylase deficiency in tumors: A compelling therapeutic target

Frontiers in Cell and Developmental Biology, 2023
The methionine salvage pathway is responsible for recycling sulfur-containing metabolites to methionine. This salvage pathway has been found to be implicated in cell apoptosis, proliferation, differentiation and inflammatory response. Methylthioadenosine
Na Fan, Yi Zhang, Suyun Zou
doaj   +1 more source

Regulation of phosphorylase kinase by low concentrations of Ca ions upon muscle contraction: the connection between metabolism and muscle contraction and the connection between muscle physiology and Ca-dependent signal transduction

Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2011
It had long been one of the crucial questions in muscle physiology how glycogenolysis is regulated in connection with muscle contraction, when we found the answer to this question in the last half of the 1960s. By that time, the two principal currents of
E. Ozawa
semanticscholar   +1 more source

PKCζ Phosphorylates SIRT6 to Mediate Fatty Acid β-Oxidation in Colon Cancer Cells

Neoplasia: An International Journal for Oncology Research, 2019
Protein kinase C (PKC) has critical roles in regulating lipid anabolism and catabolism. PKCζ, a member of atypical PKC family, has been reported to mediate glucose metabolism. However, whether and how PKCζ regulates tumor cells fatty acid β-oxidation are
Tian Gao, Meiting Li, Guanqun Mu, Tianyun Hou, Wei-Guo Zhu, Yang Yang   +5 more
doaj   +1 more source

Targeting thymidine phosphorylase as a potential therapy for bone loss associated with periprosthetic osteolysis

Bioengineering & Translational Medicine, 2021
Macrophages are generally thought to play a key role in the pathogenesis of aseptic loosening through initiating periprosthetic inflammation and pathological bone resorption.
Gen Matsumae, Tomohiro Shimizu, Yuan Tian, Daisuke Takahashi, Taku Ebata, Hend Alhasan, Shunichi Yokota, Ken Kadoya, Mohamad Alaa Terkawi, Norimasa Iwasaki   +9 more
doaj   +1 more source

Artificial Photosynthesis Would Unify the Electricity-Carbohydrate-Hydrogen Cycle for Sustainability [PDF]

, 2010
Sustainable development requires balanced integration of four basic human needs – air (O2/CO2), water, food, and energy. To solve key challenges, such as CO2 fixation, electricity storage, food production, transportation fuel production, water ...
Yi-Heng Percival Zhang
core   +2 more sources

Inhibition of glycogen phosphorylase stimulates ventromedial hypothalamic nucleus AMP‐activated protein kinase

Physiological Reports, 2017
The glucose polymer glycogen is a vital fuel reserve in the brain. The mediobasal hypothalamic energy sensor AMP‐activated protein kinase (AMPK) maintains glucostasis via neurotransmitter mechanisms that suppress [γ‐aminobutyric acid; GABA] or stimulate [
Hussain N. Alhamami, Ayed Alshamrani, Karen P. Briski   +2 more
doaj   +1 more source

Chrysoeriol ameliorates hyperglycemia by regulating the carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats

Food Science and Human Wellness, 2020
The present study aimed to evaluate the effects of chrysoeriol from Cardiospermum halicacabum in streptozotocin induced Wistar rats. Thirty rats were categorized as control, diabetic control supplemented with 0, 20 mg/kg chrysoeriol and 600 μg/kg BW of ...
Baskaran Krishnan, Abirami Ramu Ganesan, Ravindran Balasubramani, Dinh Duc Nguyen, Soon Woong Chang, Shaoyun Wang, Jianbo Xiao, Balamuralikrishnan Balasubramanian   +7 more
doaj   +1 more source

Pancreatic cancer-associated diabetes mellitus: an open field for proteomic applications. [PDF]

, 2005
Background: Diabetes mellitus is associated with pancreatic cancer in more than 80% of the cases. Clinical, epidemiological, and experimental data indicate that pancreatic cancer causes diabetes mellitus by releasing soluble mediators which interfere ...
BALDO G, BASSO D, FLAGIELLO A, FOGAR P, GIUNCO S, GRECO E, NAVAGLIA F, PEDRAZZOLI S, PLEBANI M., PUCCI, PIETRO, VALERIO A, ZAMBON CF   +11 more
core   +1 more source

Analysis of myofibrillar and sarcoplasmic proteins in pork meat by capillary gel electrophoresis

Foods and Raw Materials, 2018
Myofibrillar and sarcoplasmic proteins were extracted from pork meat (M. Longissimus dorsi) and then separated by capillary gel electrophoresis (CGE). Migration time and peak areas of individual protein molecules in the electropherogram were analysed ...
Radoslav Grujić, Danica Savanović
doaj   +1 more source

Investigating the Role of Guanosine on Human Neuroblastoma Cell Differentiation and the Underlying Molecular Mechanisms

Frontiers in Pharmacology, 2021
Neuroblastoma arises from neural crest cell precursors failing to complete the process of differentiation. Thus, agents helping tumor cells to differentiate into normal cells can represent a valid therapeutic strategy.
Natale Belluardo, Giuseppa Mudò, Valentina Di Liberto, Monica Frinchi, Daniele F. Condorelli, Ugo Traversa, Francisco Ciruela, Francisco Ciruela, Renata Ciccarelli, Renata Ciccarelli, Patrizia Di Iorio, Patrizia Di Iorio, Patricia Giuliani, Patricia Giuliani   +13 more
doaj   +1 more source