Results 71 to 80 of about 900,190 (260)

1-Deoxynojirimycin Alleviates Liver Injury and Improves Hepatic Glucose Metabolism in db/db Mice

Molecules, 2016
The present study investigated the effect of 1-Deoxynojirimycin (DNJ) on liver injury and hepatic glucose metabolism in db/db mice. Mice were divided into five groups: normal control, db/db control, DNJ-20 (DNJ 20 mg·kg−1·day−1), DNJ-40 (DNJ 40 mg·kg−1 ...
Qingpu Liu, Xuan Li, Cunyu Li, Yunfeng Zheng, Fang Wang, Hongyang Li, Guoping Peng   +6 more
doaj   +1 more source

Autoimmunity in MASLD: Focus on autoantibodies, anti‐apolipoprotein A1 IgG and G protein‐coupled receptors

European Journal of Clinical Investigation, EarlyView.
This review outlines the potential role of anti‐GPCR autoantibodies in MASLD/MASH, given their involvement in a wide range of diseases and their possible contribution to MASLD/MASH pathophysiology. We also focused on anti‐ApoA1 autoantibodies, sharing functional features with anti‐GPCR autoantibodies and have been shown to promote liver steatosis in ...
Sabrina Pagano, Emmanuel Somm, François R. Jornayvaz, Nicolas Vuilleumier   +3 more
wiley   +1 more source

Maximizing efficiency of rumen microbial protein production. [PDF]

, 2015
Rumen microbes produce cellular protein inefficiently partly because they do not direct all ATP toward growth. They direct some ATP toward maintenance functions, as long-recognized, but they also direct ATP toward reserve carbohydrate synthesis and ...
Andries, Argyle, Armstead, Asanuma, Asanuma, Atasoglu, Atasoglu, Atasoglu, Bailey, Bailey, Baldwin, Baldwin, Bas, Bond, Bond, Bond, Buurman, Caldara, Chen, Cheng, Clapperton, Clark, Cook, Costerton, Cotta, Cotta, Counotte, Denton, Diaz, Diez-Gonzalez, Dijkstra, Dijkstra, Dijkstra, Duncan, Dunne, Falony, Ferla, Fields, Firkins, Firkins, Firkins, Firkins, Flint, Forsberg, Gaudet, Gottschalk, Hackmann, Hackmann, Hackmann, Hall, Hanigan, Hindson, Hino, Hobson, Hobson, Hottiger, Hristov, Hristov, Isaacson, Janssen, Jenkins, Jouany, Kajikawa, Kajikawa, Kajikawa, Kalcheva, Karnati, Kim, Koenig, Krause, Kristensen, Larsson, Leedle, Lohkamp, Lou, Lou, Lou, Louis, Mackie, Maia, Martin, Matheron, Matulova, McAllan, Morgan, Morgavi, Morrison, Morrison, Mountfort, Mouriño, Mulder, Nagaraja, Neijssel, Newbold, Newsholme, Newsholme, Nouaille, NRC., Oldick, Or-Rashid, Otto, Paillard, Paulus, Pirt, Piwonka, Portais, Prabhu, Preiss, Prins, Rosewarne, Russell, Russell, Russell, Russell, Russell, Russell, Russell, Russell, Russell, Russell, Russell, Russell, Russell, Ryan, Saleem, Schönheit, Shi, Shi, Stewart, Storm, Stouthamer, Suen, Teixeira de Mattos, Tempest, Tempest, Ungerfeld, van Hijum, Van Hoven, Van Kessel, Van Kessel, Van Soest, Van Urk, Vandehaar, Walker, Wallace, Wallace, Wang, Weimer, Weimer, Weimer, Wells, Wells, White, Wilkinson, Williams, Williams, Yang, Ze, Zhou   +158 more
core   +2 more sources

Human FASTK preferentially binds single‐stranded and G‐rich RNA

The FEBS Journal, EarlyView.
Although FASTK is known to play a role in mRNA biology, the mechanism through which it recognizes RNA has yet to be unraveled. Here, we used purified human FASTK to characterize its RNA‐binding properties in vitro. We found that FASTK prefers ssRNA oligonucleotides containing guanines with the potential to form G‐quadruplexes and binds robustly to any ...
Daria M. Dawidziak, Dawid A. Dzadz, Mikołaj I. Kuska, Madhuri Kanavalli, Maria M. Klimecka, Matthew Merski, Katarzyna J. Bandyra, Maria W. Górna   +7 more
wiley   +1 more source

Selective Phosphorylation of Phenols and Benzenediols by the Kinase PsiK and Variants Thereof

Angewandte Chemie, Volume 137, Issue 34, August 18, 2025.
PsiK from Psilocybe cubensis phosphorylates a diverse set of substituted phenols and benzenediols beyond its native substrate. High‐throughput screening of active site mutant libraries using DESI‐MS enabled protein engineering of PsiK, further expanding its substrate scope.
Ahram Kim, Nicolás M. Morato, Prabir Saha, Pascal N. Eyimegwu, Aqeel A. Niyaz, Rui Huang, R. Graham Cooks, Ryan M. Phelan, Jared C. Lewis   +8 more
wiley   +2 more sources

Clinical and biochemical improvements in a patient with MNGIE following enzyme replacement. [PDF]

, 2013
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive metabolic disorder caused by a deficiency of thymidine phosphorylase (TP, EC2.4.2.4) due to mutations in the nuclear gene TYMP.
Bain, MD, Bax, BE, Filosto, M, Moran, N, Scarpelli, M, Tonin, P   +5 more
core   +1 more source

A phosphoserine phosphatase variant present in the brain of Alzheimer's disease patients favors nuclear mistargeting

The FEBS Journal, EarlyView.
l‐serine levels in the human brain are maintained by the phosphorylated pathway, a three‐step process catalyzed by phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase (PSAT) and phosphoserine phosphatase (PSP). These enzymes assemble in a metabolon called the serinosome. The double R27S/D32G PSP variant was identified in the brain of
Silvia Sacchi, Valeria Buoli Comani, Ivan Arisi, Francesco Marchesani, Valentina Rabattoni, Omar De Bei, Zoraide Motta, Alessio Peracchi, Stefano Bruno, Loredano Pollegioni, Barbara Campanini   +10 more
wiley   +1 more source

Rhabdomyolysis: a genetic perspective [PDF]

, 2015
Rhabdomyolysis (RM) is a clinical emergency characterized by fulminant skeletal muscle damage and release of intracellular muscle components into the blood stream leading to myoglobinuria and, in severe cases, acute renal failure.
Alice R Gardiner, Edmar Zanoteli, Heinz Jungbluth, Henry Houlden, Janice L Holton, Jefferson Becker, Renata Siciliani Scalco, Robert DS Pitceathly, Ros Quinlivan   +8 more
core   +4 more sources

Effects of Fasting on Intermediary Metabolism Enzymes in the Liver and Muscle of Rainbow Trout

Fishes, 2023
Fish can go through periods of feed deprivation, either due to natural causes influenced by temperature or management techniques in animal production, affecting their energy metabolism differently, depending on the duration of fasting in days and water ...
Montserrat Fernández-Muela, Rubén Bermejo-Poza, Almudena Cabezas, Concepción Pérez, Elisabet González de Chavarri, María Teresa Díaz, Fernando Torrent, Morris Villarroel, Jesús De la Fuente   +8 more
doaj   +1 more source

Loss of MTAP expression is not an accurate surrogate for CDKN2A homozygous deletions in peritoneal mesothelioma

Histopathology, EarlyView.
MTAP immunohistochemistry (IHC) was evaluated as a diagnostic tool for peritoneal mesothelioma by comparing it with CDKN2A homozygous deletion (HD) detected by FISH. Results showed low concordance between MTAP IHC and CDKN2A HD, suggesting MTAP IHC is not reliable for predicting CDKN2A HD in peritoneal mesothelioma. Further studies are needed.
Andrea Quaranta, Andrea Marzullo, Francesco Fortarezza, Sonia Maniglio, Concetta Caporusso, Floriana Pentimone, Federica Pezzuto, Domenica Cavone, Teresa Lettini, Mario Magistro, Cecilia Salzillo, Luigi Vimercati, Paolo Graziano, Gabriella Serio, Antonio d'Amati   +14 more
wiley   +1 more source