Results 201 to 210 of about 2,046,842 (395)

Loss of PDZK1 expression activates PI3K/AKT signaling via PTEN phosphorylation in gastric cancer

, 2019
Chunjuan Zhao, Tao Tao, Longyan Yang, Qiong Qin, Ying Wang, Hua Liu, Ran Song, Xiaomei Yang, Qiqi Wang, Siyu Gu, Ying Xiong, Dong Zhao, Songlin Wang, Duiping Feng, Wen G. Jiang, Jun Zhang, Junqi He   +16 more
openalex   +2 more sources

Inhibition of Nwd1 activity attenuates neuronal hyperexcitability and GluN2B phosphorylation in the hippocampus [PDF]

, 2019
Qin Yang, Zifeng Huang, Yangfu Luo, Fangshuo Zheng, Yida Hu, Hui Liu, Shuzhen Zhu, Miaoqing He, Demei Xu, Yun Li, Min Yang, Yi Yang, Xiaobo Wei, Xiaoya Gao, Wei Wang, Junhong Ma, Yuanlin Ma, Xuefeng Wang, Qing Wang   +18 more
openalex   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

Science, 2015
Siqi Liu, Xin Cai, Jiaxi Wu, Qian Cong, Xiang Chen, Tuo Li, Fenghe Du, Junyao Ren, Youtong Wu, N. Grishin, Zhijian J. Chen   +10 more
semanticscholar   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

Proceedings of the National Academy of Sciences of the United States of America, 1986
I. Grundke‐Iqbal, K. Iqbal, Y. Tung, M. Quinlan, H. Wiśniewski, L. Binder   +5 more
semanticscholar   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

EARLY STARVATION1 specifically affects the phosphorylation action of starch‐related dikinases [PDF]

, 2018
Irina Malinova, Harendra Mahto, Felix Brandt, Shadha Abduljaleel AL‐Rawi, Hadeel Qasim, Henrike Brust, Mahdi Hejazi, Joerg Fettke   +7 more
openalex   +1 more source

Phosphorylation of Proteins [PDF]

Biochemical Journal, 1927
openaire   +2 more sources

Structural basis of STING binding with and phosphorylation by TBK1

Nature, 2019
Conggang Zhang, G. Shang, Xiang Gui, Xuewu Zhang, X. Bai, Zhijian J. Chen   +5 more
semanticscholar   +1 more source