Results 221 to 230 of about 2,046,842 (395)

MAST4 promotes primary ciliary resorption through phosphorylation of Tctex-1 [PDF]

, 2023
Kensuke Sakaji, Sara Ebrahimiazar, Yasuhiro Harigae, Kenichi Ishibashi, Takeya Sato, Takeo Yoshikawa, Gen‐ichi Atsumi, Ching‐Hwa Sung, Masaki Saito   +8 more
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

BE screen reveals METTL3 S2 dephosphorylation sensitizes gastric cancer cells to oxaliplatin by interfering METTL3-eIF3H interaction. [PDF]

Sci Adv
Xu X, Tao W, Liu Y, Guo T, Zhang Y, Wei D, Yan P, Huang X, Wei Y.   +8 more
europepmc   +1 more source

Functional phosphorylation [PDF]

Nature Chemical Biology, 2018
openaire   +2 more sources

Oxidative Phosphorylation as an Emerging Target in Cancer Therapy

Clinical Cancer Research, 2018
Thomas M. Ashton, G. McKenna, L. Kunz-Schughart, G. Higgins   +3 more
semanticscholar   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Deep learning model of post-translational modification regulating liquid-liquid phase separation. [PDF]

Commun Chem
Hong X, Lv J, Li Z, Zhu J, Li J, Rahman MU, Wei T, Mu J, Chen HF.   +8 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Role of histone-lysine N-methyltransferase 2D (KMT2D) in MEK-ERK signaling-mediated epigenetic regulation: a phosphoproteomics perspective. [PDF]

Front Bioinform
Kammarambath SR, Dcunha L, Gopalakrishnan AP, Fahma A, Krishna N, Mahin A, Ummar S, Shivamurthy PB, Madar IH, Raju R.   +9 more
europepmc   +1 more source

PRAS40 Phosphorylation Correlates with Insulin-Like Growth Factor-1 Receptor-Induced Resistance to Epidermal Growth Factor Receptor Inhibition in Head and Neck Cancer Cells [PDF]

, 2020
Michael I. Dougherty, Christine E. Lehman, Adam Spencer, Rolando E. Mendez, Abel P. David, Linnea E. Taniguchi, Julie Wulfkuhle, Emanuel F. Petricoin, Daniel Gioeli, Mark J. Jameson   +9 more
openalex   +1 more source