Results 201 to 210 of about 1,166,192 (319)

Correction: LCK'ed in: Inborn errors of immunity in LCK reveal how TCR signaling is calibrated. [PDF]

J Exp Med
Eken A, Johnson SA, Erdem S, Hsieh EWY.
europepmc   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Phosphorylation remodels the mitotic centrosome matrix to generate bipartite γ-tubulin complex docking sites. [PDF]

Sci Adv
Ohta M, Arakawa O, Gu Y, Tian W, Corbett KD, Desai A, Oegema K.   +6 more
europepmc   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

LATS kinase activity and tumor suppressor function are regulated by a second autophosphorylation site. [PDF]

J Biol Chem
Jin R, Zhong Z, Zhu R, Zhang A, Li J, Yu FX, Wang Y.   +6 more
europepmc   +1 more source

PHOSPHORYLATIVE AND NON-PHOSPHORYLATIVE OXIDATION IN ACETOBACTER SUBOXYDANS

Journal of Biological Chemistry, 1952
T E, KING, V H, CHELDELIN
openaire   +2 more sources

Macrophage Membrane‐Camouflaged Nanozyme Microneedles Restore Immunovascular Homeostasis Through SPP1‐ApoE Signaling in Diabetic Wounds

Advanced Healthcare Materials, EarlyView.
Macrophage membrane‐coated Cu/Zn‐MOF nanozyme microneedles (MNs) reprogram the diabetic wound microenvironment through localized, minimally invasive delivery. By suppressing M1‐like macrophage activation while promoting extracellular matrix deposition and angiogenesis, this biomimetic platform accelerates diabetic wound repair.
Qipeng Wu, Yuan Xiong, Li Lu, Han Wang, Hui Hu, Mohammad‐Ali Shahbazi, Guohui Liu, Bobin Mi   +7 more
wiley   +1 more source

Recent advances in phosphoproteomics based on mass spectrometry and its clinical application prospects. [PDF]

Front Pharmacol
Gao J, Wang L, Shi S, Gu Z, Liu B, Cao Y.   +5 more
europepmc   +1 more source

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source

AKT-mediated phosphorylation of ZDHHC5 promotes NOD1 palmitoylation and innate immune signaling. [PDF]

Front Immunol
Mi S, Zhu Y, Li Q, Wang X, Guo X, Chen Y.   +5 more
europepmc   +1 more source