Results 1 to 10 of about 19,899 (238)

Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers

Acta Neuropathologica Communications, 2017
Missense mutations in the leucine-rich repeat kinase 2 (LRRK2) gene can cause late-onset Parkinson disease (PD). LRRK2 mutations increase LRRK2 kinase activities that may increase levels of LRRK2 autophosphorylation at serine 1292 (pS1292) and ...
Shijie Wang, Zhiyong Liu, Tao Ye, Omar S. Mabrouk, Tyler Maltbie, Jan Aasly, Andrew B. West   +6 more
doaj   +2 more sources

Lack of correlation between the kinase activity of LRRK2 harboring kinase-modifying mutations and its phosphorylation at Ser910, 935, and Ser955. [PDF]

PLoS ONE, 2014
Leucine-rich repeat kinase 2 (LRRK2) is extensively phosphorylated in cells within a region amino-terminal to the leucine-rich repeat domain. Since phosphorylation in this region of LRRK2, including Ser910, Ser935, Ser955, and Ser973, is significantly ...
Genta Ito, Tetta Fujimoto, Shogo Kamikawaji, Tomoki Kuwahara, Takeshi Iwatsubo   +4 more
doaj   +1 more source

Leucine-rich repeat kinase-2 deficiency protected against cardiac remodelling in mice via regulating autophagy formation and degradation

Journal of Advanced Research, 2022
Introduction: Leucine-rich repetitive kinase-2 (LRRK2) is a Parkinson's disease-related gene that also participates in many inflammatory diseases. However, the functional role of LRRK2 in cardiovascular disease is not clear.
Yuan Liu, Congqing Hao, Wei Zhang, Yuzhou Liu, Sen Guo, Ran Li, Meng Peng, Yawei Xu, Xiaoxin Pei, Haibo Yang, Yintao Zhao   +10 more
doaj   +1 more source

GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1. [PDF]

PLoS Genetics, 2012
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of autosomal dominant familial Parkinson's disease (PD) and also contribute to idiopathic PD. LRRK2 encodes a large multi-domain protein with GTPase and kinase activity.
Klodjan Stafa, Alzbeta Trancikova, Philip J Webber, Liliane Glauser, Andrew B West, Darren J Moore   +5 more
doaj   +1 more source

Effect of LRRK2 protein and activity on stimulated cytokines in human monocytes and macrophages

npj Parkinson's Disease, 2022
Leucine-rich-repeat kinase 2 (LRRK2), a potential therapeutic target for the treatment of Parkinson’s disease (PD), is highly expressed in monocytes and macrophages and may play a role in the regulation of inflammatory pathways.
Diba Ahmadi Rastegar, Laura P. Hughes, Gayathri Perera, Shikara Keshiya, Siying Zhong, Jianqun Gao, Glenda M. Halliday, Birgitt Schüle, Nicolas Dzamko   +8 more
doaj   +1 more source

The effect of high intensity interval swimming on LRRK2 and mir-205 gene expression in rats with Parkinson’s disease [PDF]

ورزش و علوم زیست حرکتی
Introduction and Purpose: Dysregulation of miRNAs will result in development and progression of numerous diseases, such as in Parkinson’s disease (PD). The effect of exercise training on mechanisms of development and progression of PD are not well known.
Somayeh Rashidfard, Mehrzad Moghadasi, Mohammdamin Edalatmanesh, Sara Hojati   +3 more
doaj   +1 more source

Parkinson’s disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging

Molecular Neurodegeneration, 2020
Background Multiple missense mutations in Leucine-rich repeat kinase 2 (LRRK2) are associated with familial forms of late onset Parkinson’s disease (PD), the most common age-related movement disorder.
Xi Chen, Chengsong Xie, Wotu Tian, Lixin Sun, Zheng Wang, Sarah Hawes, Lisa Chang, Justin Kung, Jinhui Ding, Shengdi Chen, Weidong Le, Huaibin Cai   +11 more
doaj   +1 more source

GTPase activity plays a key role in the pathobiology of LRRK2. [PDF]

PLoS Genetics, 2010
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with late-onset, autosomal-dominant, familial Parkinson's disease (PD) and also contribute to sporadic disease.
Yulan Xiong, Candice E Coombes, Austin Kilaru, Xiaojie Li, Aaron D Gitler, William J Bowers, Valina L Dawson, Ted M Dawson, Darren J Moore   +8 more
doaj   +1 more source

LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice

Acta Neuropathologica Communications, 2019
Mutations in leucine-rich repeat kinase 2 (LRRK2) are one of the most common causes of familial Parkinson’s disease (PD). The most common mutations in the LRRK2 gene induce elevated kinase activity of the LRRK2 protein. Recent studies have also suggested
Michael X. Henderson, Medha Sengupta, Ian McGeary, Bin Zhang, Modupe F. Olufemi, Hannah Brown, John Q. Trojanowski, Virginia M. Y. Lee   +7 more
doaj   +1 more source

Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease. [PDF]

PLoS ONE, 2011
Recent studies show that mutations in Leucine Rich Repeat Kinase 2 (LRRK2) are the cause of the most common inherited and some sporadic forms of Parkinson's disease (PD).
Xianting Li, Qing Jun Wang, Nina Pan, Sangkyu Lee, Yingming Zhao, Brian T Chait, Zhenyu Yue   +6 more
doaj   +1 more source