Results 1 to 10 of about 28,054 (245)

LRRK2 expression is enriched in the striosomal compartment of mouse striatum

Neurobiology of Disease, 2012
In spite of a clear genetic link between Parkinson's disease (PD) and mutations in LRRK2, cellular localization and physiological function of LRRK2 remain debated. Here we demonstrate the immunohistochemical localization of LRRK2 in adult mouse and early
Wim Mandemakers, An Snellinx, Michael J O'Neill   +2 more
exaly   +3 more sources

LRRK2 Phosphorylation, More Than an Epiphenomenon

Frontiers in Neuroscience, 2020
Mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) gene are linked to autosomal dominant Parkinson's disease (PD), and genetic variations at the LRRK2 locus are associated with an increased risk for sporadic PD.
Antoine Marchand, Marie-Christine Chartier-Harlin, Jean-Marc Taymans   +2 more
exaly   +3 more sources

Protein phosphatase 2A holoenzymes regulate leucine-rich repeat kinase 2 phosphorylation and accumulation

Neurobiology of Disease, 2021
LRRK2 is a highly phosphorylated multidomain protein and mutations in the gene encoding LRRK2 are a major genetic determinant of Parkinson's disease (PD).
Matthieu Drouyer, Marc F. Bolliger, Evy Lobbestael, Chris Van den Haute, Marco Emanuele, Réginald Lefebvre, William Sibran, Tina De Wit, Coline Leghay, Eugénie Mutez, Nicolas Dzamko, Glenda M. Halliday, Shigeo Murayama, Alain Martoriati, Katia Cailliau, Jean-François Bodart, Marie-Christine Chartier-Harlin, Veerle Baekelandt, R. Jeremy Nichols, Jean-Marc Taymans   +19 more
doaj   +1 more source

LRRK2 is involved in the chemotaxis of neutrophils and differentiated HL-60 cells, and the inhibition of LRRK2 kinase activity increases fMLP-induced chemotactic activity

Cell Communication and Signaling, 2023
Background Neutrophils depend heavily on glycolysis for energy production under normal conditions. In contrast, neutrophils require energy supplied by mitochondrial oxidative phosphorylation (OXPHOS) during chemotaxis. However, the mechanism by which the
Yuichi Mazaki, Haruka Handa, Yoshizuki Fumoto, Takahiro Horinouchi, Yasuhito Onodera   +4 more
doaj   +1 more source

Leucine-rich repeat kinase-2 deficiency protected against cardiac remodelling in mice via regulating autophagy formation and degradation

Journal of Advanced Research, 2022
Introduction: Leucine-rich repetitive kinase-2 (LRRK2) is a Parkinson's disease-related gene that also participates in many inflammatory diseases. However, the functional role of LRRK2 in cardiovascular disease is not clear.
Yuan Liu, Congqing Hao, Wei Zhang, Yuzhou Liu, Sen Guo, Ran Li, Meng Peng, Yawei Xu, Xiaoxin Pei, Haibo Yang, Yintao Zhao   +10 more
doaj   +1 more source

Alterations in the LRRK2-Rab pathway in urinary extracellular vesicles as Parkinson’s disease and pharmacodynamic biomarkers

npj Parkinson's Disease, 2023
Expression or phosphorylation levels of leucine-rich repeat kinase 2 (LRRK2) and its Rab substrates have strong potential as disease or pharmacodynamic biomarkers.
Jean-Marc Taymans, Eugénie Mutez, William Sibran, Laurine Vandewynckel, Claire Deldycke, Séverine Bleuse, Antoine Marchand, Alessia Sarchione, Coline Leghay, Alexandre Kreisler, Clémence Simonin, James Koprich, Guillaume Baille, Luc Defebvre, Kathy Dujardin, Alain Destée, Marie-Christine Chartier-Harlin   +16 more
doaj   +1 more source

Lack of correlation between the kinase activity of LRRK2 harboring kinase-modifying mutations and its phosphorylation at Ser910, 935, and Ser955. [PDF]

PLoS ONE, 2014
Leucine-rich repeat kinase 2 (LRRK2) is extensively phosphorylated in cells within a region amino-terminal to the leucine-rich repeat domain. Since phosphorylation in this region of LRRK2, including Ser910, Ser935, Ser955, and Ser973, is significantly ...
Genta Ito, Tetta Fujimoto, Shogo Kamikawaji, Tomoki Kuwahara, Takeshi Iwatsubo   +4 more
doaj   +1 more source

Effect of LRRK2 protein and activity on stimulated cytokines in human monocytes and macrophages

npj Parkinson's Disease, 2022
Leucine-rich-repeat kinase 2 (LRRK2), a potential therapeutic target for the treatment of Parkinson’s disease (PD), is highly expressed in monocytes and macrophages and may play a role in the regulation of inflammatory pathways.
Diba Ahmadi Rastegar, Laura P. Hughes, Gayathri Perera, Shikara Keshiya, Siying Zhong, Jianqun Gao, Glenda M. Halliday, Birgitt Schüle, Nicolas Dzamko   +8 more
doaj   +1 more source

The effect of high intensity interval swimming on LRRK2 and mir-205 gene expression in rats with Parkinson’s disease [PDF]

ورزش و علوم زیست حرکتی
Introduction and Purpose: Dysregulation of miRNAs will result in development and progression of numerous diseases, such as in Parkinson’s disease (PD). The effect of exercise training on mechanisms of development and progression of PD are not well known.
Somayeh Rashidfard, Mehrzad Moghadasi, Mohammdamin Edalatmanesh, Sara Hojati   +3 more
doaj   +1 more source

Fbxl18 targets LRRK2 for proteasomal degradation and attenuates cell toxicity

Neurobiology of Disease, 2017
Dominantly inherited mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common causes of familial Parkinson's disease (PD) and LRRK2 polymorphisms are associated with increased risk for idiopathic PD.
Xiaodong Ding, Sandeep K. Barodia, Lisha Ma, Matthew S. Goldberg   +3 more
doaj   +1 more source