Results 41 to 50 of about 19,899 (238)

ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2. [PDF]

PLoS ONE, 2010
Mutations within the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of familial and sporadic Parkinson's disease. The multidomain protein LRRK2 exhibits overall low GTPase and kinase activity in vitro.Here, we show that the rho guanine ...
Karina Haebig, Christian Johannes Gloeckner, Marta Garcia Miralles, Frank Gillardon, Claudia Schulte, Olaf Riess, Marius Ueffing, Saskia Biskup, Michael Bonin   +8 more
doaj   +1 more source

Reduced LRRK2 in association with retromer dysfunction in post-mortem brain tissue from LRRK2 mutation carriers [PDF]

, 2017
Missense mutations in leucine-rich repeat kinase 2 (LRRK2) are pathogenic for familial Parkinson's disease. However, it is unknown whether levels of LRRK2 protein in the brain are altered in patients with LRRK2-associated Parkinson's disease.
Ye Zhao, Perera, Gayathri, Halliday, Glenda M, Kazuko Hasegawa, Akiko Uchino, Glenda M Halliday, Holton, Janice L, Janice L Holton, Junko Takahashi-Fujigasaki, Takahashi-Fujigasaki, Junko, Hasegawa, Kazuko, Murayama, Shigeo, Shigeo Murayama, Zhao, Ye, Dzamko, Nicolas, Gayathri Perera, Mash, Deborah C, Uchino, Akiko, R Jeremy Nichols, Nicolas Dzamko, Deborah C Mash, Jeremy Nichols, R, Jean Paul G Vonsattel, Vonsattel, Jean Paul G   +23 more
core   +3 more sources

Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pT73 Rab10

Scientific Reports, 2021
Variants in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with increased risk for familial and sporadic Parkinson’s disease (PD). Pathogenic variants in LRRK2, including the common variant G2019S, result in increased LRRK2 kinase activity,
Xiang Wang, Elvira Negrou, Michael T. Maloney, Vitaliy V. Bondar, Shan V. Andrews, Manuel Montalban, Ceyda Llapashtica, Romeo Maciuca, Hoang Nguyen, Hilda Solanoy, Annie Arguello, Laralynne Przybyla, Nathan J. Moerke, Sarah Huntwork-Rodriguez, Anastasia G. Henry   +14 more
doaj   +1 more source

Tissue specific LRRK2 interactomes reveal a distinct striatal functional unit.

PLoS Computational Biology, 2023
Mutations in LRRK2 are the most common genetic cause of Parkinson's disease. Despite substantial research efforts, the physiological and pathological role of this multidomain protein remains poorly defined. In this study, we used a systematic approach to
Yibo Zhao, Nikoleta Vavouraki, Ruth C Lovering, Valentina Escott-Price, Kirsten Harvey, Patrick A Lewis, Claudia Manzoni   +6 more
doaj   +1 more source

LRRK2 MD simulation models

, 2023
PDB Models Extracted from GaMD Simulations  rckw.WT : LRRK2 RCKW (1330-2527)  rckw.R1398H: LRRK2 RCKW (1330-2527) R1398H  lrrk2.WT: LRRK2 (558-855; 982-2527)  lrrk2.R1398H.: LRRK2 (558-855; 982-2527 ...
Jui-Hung Weng (15213073)
core   +1 more source

A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively

Cells, 2022
The Leucine Rich Repeat Kinase 2 (LRRK2) gene is a major genetic determinant of Parkinson’s disease (PD), encoding a homonymous multi-domain protein with two catalytic activities, GTPase and Kinase, involved in intracellular signaling and trafficking ...
Antoine Marchand, Alessia Sarchione, Panagiotis S. Athanasopoulos, Hélène Bauderlique-Le Roy, Liesel Goveas, Romain Magnez, Matthieu Drouyer, Marco Emanuele, Franz Y. Ho, Maxime Liberelle, Patricia Melnyk, Nicolas Lebègue, Xavier Thuru, R. Jeremy Nichols, Elisa Greggio, Arjan Kortholt, Thierry Galli, Marie-Christine Chartier-Harlin, Jean-Marc Taymans   +18 more
doaj   +1 more source

Olfactory identification in LRRK2 G2019S mutation carriers: a relevant marker? [PDF]

, 2014
ObjectiveOlfactory impairment is a potential marker for impending phenoconversion to Parkinson disease (PD) that may precede the development of disease by several years.
Wang, Cuiling, Mejia‐Santana, Helen, Clark, Lorraine, Raymond, Deborah, Mirelman, Anat, San Luciano, Marta, Giladi, Nir, Ortega, Robert, Alcalay, Roy N, Ozelius, Laurie, Consortium, the AJ LRRK2, Bressman, Susan B, Saunders‐Pullman, Rachel, Marder, Karen, Orr‐Utreger, Avi   +14 more
core   +1 more source

Mechanisms of LRRK2-Mediated Neurodegeneration [PDF]

Current Neurology and Neuroscience Reports, 2012
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene represent the most common cause of familial Parkinson's disease (PD), whereas common variation at the LRRK2 locus is associated with an increased risk of idiopathic PD. Considerable progress has been made toward understanding the biological functions of LRRK2 and the molecular mechanisms ...
Tsika E, Moore DJ
openaire   +3 more sources

In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2

Frontiers in Molecular Neuroscience, 2014
Leucine-rich repeat kinase 2 (LRRK2) is a complex, multidomain protein which is considered a valuable target for potential disease-modifying therapeutic strategies for Parkinson’s disease.
Renee eVancraenenbroeck, Joren eDe Raeymaecker, Evy eLobbestael, Fangye eGao, Marc eDe Maeyer, Arnout eVoet, Veerle eBaekelandt, Jean-Marc eTaymans   +7 more
doaj   +1 more source

LRRK2 Phosphorylation, More Than an Epiphenomenon

Frontiers in Neuroscience, 2020
Mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) gene are linked to autosomal dominant Parkinson's disease (PD), and genetic variations at the LRRK2 locus are associated with an increased risk for sporadic PD.
Antoine Marchand, Antoine Marchand, Matthieu Drouyer, Matthieu Drouyer, Alessia Sarchione, Alessia Sarchione, Marie-Christine Chartier-Harlin, Marie-Christine Chartier-Harlin, Jean-Marc Taymans, Jean-Marc Taymans   +9 more
doaj   +1 more source