Results 41 to 50 of about 28,054 (245)

P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity [PDF]

, 2018
Autosomal-dominant, missense mutations in the leucine-rich repeat protein kinase 2 (LRRK2) gene are the most common genetic predisposition to develop Parkinson’s disease (PD).
Abeliovich, Alegre-Abarrategui, Alegre-Abarrategui, Alegre-Abarrategui, Alexia F. Kalogeropulou, Anna Memou, Arrigo, Athanasopoulos, Bailey, Bang, Beausoleil, Beilina, Berg, Berger, Berwick, Biosa, Caesar, Carra, Christian, Cookson, Cookson, Di Fonzo, Di Fonzo, Ding, Doggett, Farrer, Fell, Filimonenko, Geetha, Gilsbach, Godena, Goedert, Gotthardt, Greggio, Greggio, Guaitoli, Gómez-Suaga, Götzl, Hardy J. Rideout, Hashimoto, Healy, Henderson, Hinkle, Hornbeck, Hsieh, Ichimura, Imai, Ito, Jaleel, Jiang, Jing Zhao, Joshi, Katsuragi, Kawakami, Kett, Kim, Ko, Kuusisto, Kuusisto, Law, Lesage, Lim, Lin, Linares, Linares, Liu, Liu, Lobbestael, Majcher, Manzoni, Manzoni, Marc F. Bolliger, Martin, Mata, Matsumoto, Matsumoto, Melachroinou, Mertins, Moscat, Moscat, Moscat, Narayan, Nichols, Nichols, Orenstein, Paisán-Ruiz, Paisán-Ruíz, Parisiadou, Park, Pilli, Plowey, Plowey, R. Jeremy Nichols, Ran, Reed, Reynolds, Roosen, Rudenko, Rudenko, Sacino, Saez-Atienzar, Sancho, Sanders, Schapansky, Schulz-Schaeffer, Seibenhener, Seibenhener, Seibenhener, Sheng, Shreya Narasimha, Skibinski, Skipper, Smith, Soukup, Spillantini, Stafa, Steger, Su, Tanji, Terni, Thirstrup, Tong, Tong, Toyofuku, Tyler P. Molitor, Ugun-Klusek, Vitari, Wagner, Wang, Watanabe, Watanabe, West, West, William H. Wilson, Yang, Yue, Zatloukal, Zimprich   +137 more
core   +2 more sources

In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2

Frontiers in Molecular Neuroscience, 2014
Leucine-rich repeat kinase 2 (LRRK2) is a complex, multidomain protein which is considered a valuable target for potential disease-modifying therapeutic strategies for Parkinson’s disease.
Renee eVancraenenbroeck, Joren eDe Raeymaecker, Evy eLobbestael, Fangye eGao, Marc eDe Maeyer, Arnout eVoet, Veerle eBaekelandt, Jean-Marc eTaymans   +7 more
doaj   +1 more source

LRRK2 Regulates CPT1A to Promote β-Oxidation in HepG2 Cells

Molecules, 2020
Leucine-rich repeat kinase 2 (LRRK2) is involved in lipid metabolism; however, the role of LRRK2 in lipid metabolism to affect non-alcoholic fatty liver disease (NAFLD) is still unclear. In the mouse model of NAFLD induced by a high-fat diet, we observed
Chiao-Wei Lin, Yu-Ju Peng, Yuan-Yu Lin, Harry John Mersmann, Shih-Torng Ding   +4 more
doaj   +1 more source

A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively

Cells, 2022
The Leucine Rich Repeat Kinase 2 (LRRK2) gene is a major genetic determinant of Parkinson’s disease (PD), encoding a homonymous multi-domain protein with two catalytic activities, GTPase and Kinase, involved in intracellular signaling and trafficking ...
Antoine Marchand, Alessia Sarchione, Panagiotis S. Athanasopoulos, Hélène Bauderlique-Le Roy, Liesel Goveas, Romain Magnez, Matthieu Drouyer, Marco Emanuele, Franz Y. Ho, Maxime Liberelle, Patricia Melnyk, Nicolas Lebègue, Xavier Thuru, R. Jeremy Nichols, Elisa Greggio, Arjan Kortholt, Thierry Galli, Marie-Christine Chartier-Harlin, Jean-Marc Taymans   +18 more
doaj   +1 more source

Expression Analysis of Lrrk1, Lrrk2 and Lrrk2 Splice Variants in Mice

PLoS ONE, 2013
Missense mutations in the leucine-rich repeat kinase 2 gene (LRRK2) are linked to autosomal dominant forms of Parkinson's disease (PD). In order to get insights into the physiological role of Lrrk2, we examined the distribution of Lrrk2 mRNA and different splice variants in the developing murine embryo and the adult brain of Mus musculus. To analyse if
Giesert, Florian, Hofmann, Andreas, Bürger, Alexander, Zerle, Julia, Kloos, Karina, Hafen, Ulrich, Ernst, Luise, Zhang, Jingzhong, Vogt-Weisenhorn, Daniela Maria, Wurst, Wolfgang   +9 more
openaire   +5 more sources

Evaluation of Current Methods to Detect Cellular Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Activity

Journal of Parkinson’s Disease, 2022
Background: Coding variation in the Leucine rich repeat kinase 2 gene linked to Parkinson’s disease (PD) promotes enhanced activity of the encoded LRRK2 kinase, particularly with respect to autophosphorylation at S1292 and/or phosphorylation of the ...
Belén Fernández, Vinita G. Chittoor-Vinod, Jillian H. Kluss, Kaela Kelly, Nicole Bryant, An Phu Tran Nguyen, Syed A. Bukhari, Nathan Smith, Antonio Jesús Lara Ordóñez, Elena Fdez, Marie-Christine Chartier-Harlin, Thomas J. Montine, Mark A. Wilson, Darren J. Moore, Andrew B. West, Mark R. Cookson, R. Jeremy Nichols, Sabine Hilfiker   +17 more
doaj   +1 more source

The Age at Onset of LRRK2 p.Gly2019Ser Parkinson's Disease Across Ancestries and Countries of Origin. [PDF]

Ann Neurol
Objectives The objective of this study was to elucidate differences in the cumulative incidence of Leucine‐rich repeat kinase 2 (LRRK2) p.Gly2019Ser‐related Parkinson's disease (PD; LRRK2‐PD) between ancestries and countries. Methods We included 922 unrelated p.Gly2019Ser variant carriers (affected = 762 and unaffected = 160) from the Global Parkinson ...
Lüth T, Laabs BH, Sendel S, König IR, Caliebe A, Noyce AJ, Screven LA, Bardien S, Farrer M, Hentati F, Amouri R, Klein C, Sassi SB, Trinh J, Global Parkinson's Genetics Program (GP2).   +14 more
europepmc   +2 more sources

Parkinson's disease biomarkers: perspective from the NINDS Parkinson's Disease Biomarkers Program [PDF]

, 2017
Biomarkers for Parkinson's disease (PD) diagnosis, prognostication and clinical trial cohort selection are an urgent need. While many promising markers have been discovered through the National Institute of Neurological Disorders and Stroke Parkinson's ...
Albin, Roger, Alcalay, Roy N., Babcock, Debra, Bowman, F. DuBois, Chen-Plotkin, Alice, David, Karen K., Dawson, Ted M., Dewey, Richard B., Jr., Foroud, Tatiana, German, Dwight, Gwinn, Katrina, Huang, Xuemei, Lungu, Codrin, Petyuk, Vlad, Potashkin, Judith A., Rosenthal, Liana S., Saunders-Pullman, Rachel, Scherzer, Clemens R., Sieber, Beth-Anne, St Hillaire-Clarke, Coryse, Sutherland, Margaret, Swanson-Fischer, Christine, Vaillancourt, David E., Walt, David R., West, Andrew B., Zhang, Jing   +25 more
core   +1 more source

Caught in the act: LRRK2 in exosomes [PDF]

Biochemical Society Transactions, 2019
Abstract Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are a frequent genetic cause of late-onset Parkinson's disease (PD) and a target for therapeutic approaches. LRRK2 protein can influence vesicle trafficking events in the cytosol, with action both in endosomal and lysosomal pathways in different types of cells.
Shijie Wang, Andrew B. West
openaire   +2 more sources

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source