Results 31 to 40 of about 28,054 (245)
Tissue specific LRRK2 interactomes reveal a distinct striatal functional unit.
PLoS Computational Biology, 2023 Mutations in LRRK2 are the most common genetic cause of Parkinson's disease. Despite substantial research efforts, the physiological and pathological role of this multidomain protein remains poorly defined. In this study, we used a systematic approach to
Yibo Zhao +6 more
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Mechanisms of LRRK2-Mediated Neurodegeneration [PDF]
Current Neurology and Neuroscience Reports, 2012 Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene represent the most common cause of familial Parkinson's disease (PD), whereas common variation at the LRRK2 locus is associated with an increased risk of idiopathic PD. Considerable progress has been made toward understanding the biological functions of LRRK2 and the molecular mechanisms ...
Elpida, Tsika, Darren J, Moore
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Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease. [PDF]
PLoS ONE, 2011 Recent studies show that mutations in Leucine Rich Repeat Kinase 2 (LRRK2) are the cause of the most common inherited and some sporadic forms of Parkinson's disease (PD).
Xianting Li +6 more
doaj +1 more source
GTPase activity plays a key role in the pathobiology of LRRK2. [PDF]
PLoS Genetics, 2010 Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with late-onset, autosomal-dominant, familial Parkinson's disease (PD) and also contribute to sporadic disease.
Yulan Xiong +8 more
doaj +1 more source
Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer disease [PDF]
, 2017 Alzheimer disease (AD), Frontotemporal lobar degeneration (FTD), Amyotrophic lateral sclerosis (ALS) and Parkinson disease (PD) have a certain degree of clinical, pathological and molecular overlap.
Alexandra Medvedeva +17 more
core +4 more sources
PLoS ONE, 2011 Leucine rich repeat kinase 2 (LRRK2) is a Parkinson's disease (PD) gene that encodes a large multidomain protein including both a GTPase and a kinase domain. GTPases often regulate kinases within signal transduction cascades, where GTPases act as molecular switches cycling between a GTP bound "on" state and a GDP bound "off" state. It has been proposed
Jean-Marc Taymans +7 more
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ArfGAP1 Is a GTPase Activating Protein for LRRK2: Reciprocal Regulation of ArfGAP1 by LRRK2 [PDF]
The Journal of Neuroscience, 2012 Both sporadic and autosomal dominant forms of Parkinson's disease (PD) have been causally linked to mutations in leucine-rich repeat kinase 2 (LRRK2), a large protein with multiple domains. The kinase domain plays an important role in LRRK2-mediated toxicity. Although a number of investigations have focused on LRRK2 kinase activity, less is known about
Yulan, Xiong +4 more
openaire +2 more sources
Reduced LRRK2 in association with retromer dysfunction in post-mortem brain tissue from LRRK2 mutation carriers [PDF]
, 2017 Missense mutations in leucine-rich repeat kinase 2 (LRRK2) are pathogenic for familial Parkinson's disease. However, it is unknown whether levels of LRRK2 protein in the brain are altered in patients with LRRK2-associated Parkinson's disease.
Dzamko, N +12 more
core +1 more source
LRRK2 kinase in Parkinson's disease [PDF]
Science, 2018 Defects in vesicular trafficking and immune responses are found in Parkinson's ...
Alessi, Dario R, Sammler, Esther
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Dynamic and redundant regulation of LRRK2 and LRRK1 expression
BMC Neuroscience, 2007 Background Mutations within the leucine-rich repeat kinase 2 (LRRK2) gene account for a significant proportion of autosomal-dominant and some late-onset sporadic Parkinson's disease. Elucidation of LRRK2 protein function in health and disease provides an
Dawson Ted M +7 more
doaj +1 more source