Results 31 to 40 of about 19,899 (238)

LRRK2 is involved in the chemotaxis of neutrophils and differentiated HL-60 cells, and the inhibition of LRRK2 kinase activity increases fMLP-induced chemotactic activity

Cell Communication and Signaling, 2023
Background Neutrophils depend heavily on glycolysis for energy production under normal conditions. In contrast, neutrophils require energy supplied by mitochondrial oxidative phosphorylation (OXPHOS) during chemotaxis. However, the mechanism by which the
Yuichi Mazaki, Haruka Handa, Yoshizuki Fumoto, Takahiro Horinouchi, Yasuhito Onodera   +4 more
doaj   +1 more source

PAK6-mediated phosphorylation of PPP2R2C regulates LRRK2-PP2A complex formation [PDF]

, 2023
Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of inherited and sporadic Parkinson's disease (PD) and previous work suggests that dephosphorylation of LRRK2 at a cluster of heterologous phosphosites is associated to disease. We have
Iannotta, Lucia, Emanuele, Marco, Athanasopoulos, Panagiotis, S, Kortholt, Arjan; id_orcid, Athanasopoulos, Panagiotis S; id_orcid, Favetta, Giulia, Civiero, Laura, Lara Ordóñez, Antonio Jesús, Nichols, R. Jeremy, Tombesi, Giulia, Vandewynckel, Laurine, Sibran, William, Drouyer, Matthieu, Athanasopoulos, Panagiotis S, Nichols, R Jeremy, Kortholt, Arjan, Taymans, Jean-Marc, Lara Ordóñez, Antonio, Jesús, Chartier-Harlin, Marie-Christine, Saliou, Jean-Michel, Greggio, Elisa   +20 more
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LRRK2 and Parkinson Disease [PDF]

Archives of Neurology, 2010
To review the molecular genetics and functional biology of leucine-rich repeat kinase 2 (LRRK2) in parkinsonism and to summarize the opportunities and challenges to develop interventions for Parkinson disease (PD) based on this genetic insight.Publications cited are focused on LRRK2 biology between 2004 and March 2009.Literature selected was based on ...
Justus C, Dächsel, Matthew J, Farrer
openaire   +2 more sources

Alterations in the LRRK2-Rab pathway in urinary extracellular vesicles as Parkinson’s disease and pharmacodynamic biomarkers

npj Parkinson's Disease, 2023
Expression or phosphorylation levels of leucine-rich repeat kinase 2 (LRRK2) and its Rab substrates have strong potential as disease or pharmacodynamic biomarkers.
Jean-Marc Taymans, Eugénie Mutez, William Sibran, Laurine Vandewynckel, Claire Deldycke, Séverine Bleuse, Antoine Marchand, Alessia Sarchione, Coline Leghay, Alexandre Kreisler, Clémence Simonin, James Koprich, Guillaume Baille, Luc Defebvre, Kathy Dujardin, Alain Destée, Marie-Christine Chartier-Harlin   +16 more
doaj   +1 more source

“LRRK2: Autophagy and Lysosomal Activity” [PDF]

Frontiers in Neuroscience, 2020
It has been 15 years since the Leucine-rich repeat kinase 2 (LRRK2) gene was identified as the most common genetic cause for Parkinson's disease (PD). The two most common mutations are the LRRK2-G2019S, located in the kinase domain, and the LRRK2-R1441C, located in the ROC-COR domain.
Marta Madureira, Marta Madureira, Natalie Connor-Robson, Richard Wade-Martins   +3 more
openaire   +3 more sources

Differential LRRK2 Signalling and Gene Expression in WT-LRRK2 and G2019S-LRRK2 Mouse Microglia Treated with Zymosan and MLi2

Cells, 2023
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause autosomal dominant Parkinson’s disease (PD), with the most common causative mutation being the LRRK2 p.G2019S within the kinase domain. LRRK2 protein is highly expressed in the human brain and also in the periphery, and high expression of dominant PD genes in immune cells suggests ...
Iqra Nazish, Adamantios Mamais, Anna Mallach, Conceicao Bettencourt, Alice Kaganovich, Thomas Warner, John Hardy, Patrick A. Lewis, Jennifer Pocock, Mark R. Cookson, Rina Bandopadhyay   +10 more
openaire   +5 more sources

A common genetic factor for Parkinson disease in ethnic Chinese population in Taiwan [PDF]

, 2006
Background: Parkinson's disease (PD) is the most common neurodegenerative movement disorder, characterized clinically by resting tremor, bradykinesia, postural instability and rigidity.
Fung Hon-Chung, Andrew B Singleton, Singleton Andrew B, Chiung-Mei Chen, Wu, YR, Wu Yih-Ru, Chen Chiung-Mei, Hardy John, Fung, HC, John Hardy, Yih-Ru Wu, Hon-Chung Fung, Hardy, J, Chen, CM, Singleton, AB   +14 more
core   +2 more sources

Assessing molecular and cellular consequences of the LRRK2:14-3-3 complex [PDF]

, 2023
openParkinson’s disease (PD) is the second most common progressive neurodegenerative disorder. The Leucine Rich Repeat Kinase 2 (LRRK2) gene is mutated in some familial PD cases and in idiopathic PD.
BURIN, ALESSIO
core  

Heterodimerization of Lrrk1–Lrrk2: Implications for LRRK2-associated Parkinson disease [PDF]

Mechanisms of Ageing and Development, 2010
LRRK2 mutations are recognized as the most frequent genetic cause of both familial and sporadic parkinsonism identified to date. A remarkable feature of this form of parkinsonism is the variable penetrance of symptom manifestation resulting in a wide range of age-at-onset in patients. Herein we use a functional approach to identify the Lrrk1 protein as
Justus C, Dachsel, Kenya, Nishioka, Carles, Vilariño-Güell, Sarah J, Lincoln, Alexandra I, Soto-Ortolaza, Jennifer, Kachergus, Kelly M, Hinkle, Michael G, Heckman, Barbara, Jasinska-Myga, Julie P, Taylor, Dennis W, Dickson, Rachel A, Gibson, Faycal, Hentati, Owen A, Ross, Matthew J, Farrer   +14 more
openaire   +2 more sources

A novel interaction between LRRK2 and Drebrin in the modulation of actin cytoskeleton. [PDF]

, 2022
openLe mutazioni nella proteina leucine-rich repeat kinase 2 (LRRK2) sono comunemente implicate nella patogenesi della malattia di Parkinson (PD). Nel corso degli anni, diversi studi hanno dimostrato l’esistenza di un'associazione fisica e funzionale tra
SANTORO, NOEMI
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