Results 11 to 20 of about 14,162 (200)

LRRK2 interactions with microtubules are independent of LRRK2-mediated Rab phosphorylation

EMBO Reports
Deregulated microtubules are common defects associated with neurodegenerative diseases. Recent cryo-electron microscopy studies in cell lines overexpressing Parkinson’s disease-associated LRRK2 suggest microtubule surfaces may regulate kinase activity by
Tuyana Malankhanova, Zhiyong Liu, Enquan Xu, Nicole Bryant, Ki Woon Sung, Huizhong Li, Samuel Strader, Andrew B West   +7 more
doaj   +3 more sources

The LRRK2 signalling system [PDF]

Cell and Tissue Research, 2018
The LRRK2 gene is a major contributor to genetic risk for Parkinson's disease and understanding the biology of the leucine-rich repeat kinase 2 (LRRK2, the protein product of this gene) is an important goal in Parkinson's research. LRRK2 is a multi-domain, multi-activity enzyme and has been implicated in a wide range of signalling events within the ...
Price, Alice, Manzoni, Claudia, Cookson, Mark R., Lewis, Patrick A.   +3 more
openaire   +2 more sources

Heterodimerization of Lrrk1–Lrrk2: Implications for LRRK2-associated Parkinson disease [PDF]

Mechanisms of Ageing and Development, 2010
LRRK2 mutations are recognized as the most frequent genetic cause of both familial and sporadic parkinsonism identified to date. A remarkable feature of this form of parkinsonism is the variable penetrance of symptom manifestation resulting in a wide range of age-at-onset in patients. Herein we use a functional approach to identify the Lrrk1 protein as
Justus C, Dachsel, Kenya, Nishioka, Carles, Vilariño-Güell, Sarah J, Lincoln, Alexandra I, Soto-Ortolaza, Jennifer, Kachergus, Kelly M, Hinkle, Michael G, Heckman, Barbara, Jasinska-Myga, Julie P, Taylor, Dennis W, Dickson, Rachel A, Gibson, Faycal, Hentati, Owen A, Ross, Matthew J, Farrer   +14 more
openaire   +3 more sources

LRRK2 and Parkinson Disease [PDF]

Archives of Neurology, 2010
To review the molecular genetics and functional biology of leucine-rich repeat kinase 2 (LRRK2) in parkinsonism and to summarize the opportunities and challenges to develop interventions for Parkinson disease (PD) based on this genetic insight.Publications cited are focused on LRRK2 biology between 2004 and March 2009.Literature selected was based on ...
Justus C, Dächsel, Matthew J, Farrer
openaire   +2 more sources

Differential LRRK2 Signalling and Gene Expression in WT-LRRK2 and G2019S-LRRK2 Mouse Microglia Treated with Zymosan and MLi2

Cells, 2023
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause autosomal dominant Parkinson’s disease (PD), with the most common causative mutation being the LRRK2 p.G2019S within the kinase domain. LRRK2 protein is highly expressed in the human brain and also in the periphery, and high expression of dominant PD genes in immune cells suggests ...
Iqra Nazish, Adamantios Mamais, Anna Mallach, Conceicao Bettencourt, Alice Kaganovich, Thomas Warner, John Hardy, Patrick A. Lewis, Jennifer Pocock, Mark R. Cookson, Rina Bandopadhyay   +10 more
openaire   +5 more sources

“LRRK2: Autophagy and Lysosomal Activity” [PDF]

Frontiers in Neuroscience, 2020
It has been 15 years since the Leucine-rich repeat kinase 2 (LRRK2) gene was identified as the most common genetic cause for Parkinson's disease (PD). The two most common mutations are the LRRK2-G2019S, located in the kinase domain, and the LRRK2-R1441C, located in the ROC-COR domain.
Marta Madureira, Marta Madureira, Natalie Connor-Robson, Richard Wade-Martins   +3 more
openaire   +3 more sources

GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1. [PDF]

PLoS Genetics, 2012
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of autosomal dominant familial Parkinson's disease (PD) and also contribute to idiopathic PD. LRRK2 encodes a large multi-domain protein with GTPase and kinase activity.
Klodjan Stafa, Alzbeta Trancikova, Philip J Webber, Liliane Glauser, Andrew B West, Darren J Moore   +5 more
doaj   +1 more source

Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers

Acta Neuropathologica Communications, 2017
Missense mutations in the leucine-rich repeat kinase 2 (LRRK2) gene can cause late-onset Parkinson disease (PD). LRRK2 mutations increase LRRK2 kinase activities that may increase levels of LRRK2 autophosphorylation at serine 1292 (pS1292) and ...
Shijie Wang, Zhiyong Liu, Tao Ye, Omar S. Mabrouk, Tyler Maltbie, Jan Aasly, Andrew B. West   +6 more
doaj   +1 more source

Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease. [PDF]

PLoS ONE, 2011
Recent studies show that mutations in Leucine Rich Repeat Kinase 2 (LRRK2) are the cause of the most common inherited and some sporadic forms of Parkinson's disease (PD).
Xianting Li, Qing Jun Wang, Nina Pan, Sangkyu Lee, Yingming Zhao, Brian T Chait, Zhenyu Yue   +6 more
doaj   +1 more source

LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice

Acta Neuropathologica Communications, 2019
Mutations in leucine-rich repeat kinase 2 (LRRK2) are one of the most common causes of familial Parkinson’s disease (PD). The most common mutations in the LRRK2 gene induce elevated kinase activity of the LRRK2 protein. Recent studies have also suggested
Michael X. Henderson, Medha Sengupta, Ian McGeary, Bin Zhang, Modupe F. Olufemi, Hannah Brown, John Q. Trojanowski, Virginia M. Y. Lee   +7 more
doaj   +1 more source