Results 21 to 30 of about 19,899 (238)
Expression Analysis of Lrrk1, Lrrk2 and Lrrk2 Splice Variants in Mice [PDF]
PLoS ONE, 2013 Missense mutations in the leucine-rich repeat kinase 2 gene (LRRK2) are linked to autosomal dominant forms of Parkinson's disease (PD). In order to get insights into the physiological role of Lrrk2, we examined the distribution of Lrrk2 mRNA and different splice variants in the developing murine embryo and the adult brain of Mus musculus. To analyse if
Giesert, F. +10 more
openaire +8 more sources
Glial Dysfunction and Memory Impairments in a Model of Pediatric Obstructive Sleep Apnea. [PDF]
GliaGeneration and analysis of an snRNA‐seq atlas of the hippocampus in POSA. Validation of reduced protein expression of six genes across four cell types. Cellular‐level investigation of aberrant glial function in POSA using transgenic reporter mice. ABSTRACT Pediatric obstructive sleep apnea (POSA) is a common childhood disease that often causes aberrant
Williamson MR +13 more
europepmc +2 more sources
Tracking Genetic Parkinson's Disease with Molecular Imaging: A Systematic Review. [PDF]
Mov Disord Clin PractAbstract Background Parkinson's disease (PD) is a worldwide, complex neurodegenerative disorder influenced by both genetic and environmental factors. Around 15–20% of PD cases are linked to genetic mutations, providing insights into the disease's pathogenesis.
Meneghini C +5 more
europepmc +2 more sources
Neuroinflammatory and Motor Alterations in LRRK2*G2019S Transgenic Mice Without Enhanced Vulnerability to Aging or Chronic MPTP-Induced Nigrostriatal Neurodegeneration. [PDF]
J NeurochemLRRK2 G2019S mutation is the most common genetic cause of Parkinson's disease but its contribution to nigrostriatal neurodegeneration, particularly in response to mitochondrial dysfunction, remains unclear. hLRRK2*G2019S transgenic mice exhibited early microglial activation and motor alterations, but not increased dopaminergic nigrostriatal ...
García-Swinburn R +8 more
europepmc +2 more sources
Biochemical Society Transactions, 2012 Mutations in LRRK2 (leucine-rich repeat kinase 2) (also known as PARK8 or dardarin) are responsible for the autosomal-dominant form of PD (Parkinson's disease). LRRK2 mutations were found in approximately 3–5% of familial and 1–3% of sporadic PD cases with the highest prevalence (up to 40%) in North Africans and Ashkenazi Jews.
Sanna, G +3 more
openaire +4 more sources
Biochemical Society Transactions, 2012 LRRK2 (leucine-rich repeat kinase 2) is a large protein encoding multiple functional domains, including two catalytically active domains, a kinase and a GTPase domain. The LRRK2 GTPase belongs to the Ras-GTPase superfamily of GTPases, more specifically to the ROC (Ras of complex proteins) subfamily.
Taymans, Jean-Marc
openaire +3 more sources
LRRK2 kinase in Parkinson's disease [PDF]
Science, 2018 Defects in vesicular trafficking and immune responses are found in Parkinson's ...
Alessi, Dario R, Sammler, Esther
openaire +5 more sources
LRRK2 G2019S Promotes Colon Cancer Potentially via LRRK2–GSDMD Axis-Mediated Gut Inflammation
CellsLeucine-rich repeat kinase 2 (LRRK2) is a serine–threonine protein kinase belonging to the ROCO protein family. Within the kinase domain of LRRK2, a point mutation known as LRRK2 G2019S has emerged as the most prevalent variant associated with Parkinson ...
Yuhang Wang +8 more
doaj +2 more sources
Characterization of a novel LRRK2 binding partner and the physiological fundtion of LRRK2
, 2016 McPherson, Peter Scott (Supervisor1)
Schreij, Anke
openaire +2 more sources
Neurobiology of Disease, 2021 LRRK2 is a highly phosphorylated multidomain protein and mutations in the gene encoding LRRK2 are a major genetic determinant of Parkinson's disease (PD).
Matthieu Drouyer +19 more
doaj +1 more source