Results 51 to 60 of about 19,899 (238)

Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease

Neurobiology of Disease, 2015
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant Parkinson's disease (PD). LRRK2 contains functional GTPase and kinase domains.
Elpida Tsika, An Phu Tran Nguyen, Julien Dusonchet, Philippe Colin, Bernard L. Schneider, Darren J. Moore   +5 more
doaj   +1 more source

Nonsteroidal Anti‐inflammatory Use and LRRK2 Parkinson's Disease Penetrance

, 2020
BACKGROUND: The penetrance of leucine rich repeat kinase 2 (LRRK2) mutations is incomplete and may be influenced by environmental and/or other genetic factors.
Goldman, Samuel M, Tanner, Caroline M, Brice, Alexis, Corvol, Jean-Christophe, San Luciano, Marta, Lang, Anthony E, Goldwurm, Stefano, Tolosa, Eduardo, Meng, Cheryl, Schule, Birgitt, Langston, J William, Mellick, George D, Klein, Christine, Marras, Connie, et al.   +14 more
core   +1 more source

Sex differences in LRRK2 G2019S and idiopathic Parkinson's Disease [PDF]

, 2017
ObjectiveTo evaluate sex differences and the relative effect of G2019S LRRK2 mutations in Parkinson's disease (PD).Methods530 LRRK2 PD carriers and 759 noncarrier PD (idiopathic, IPD) evaluated as part of the Fox Foundation (MJFF) Consortium were ...
Nir Giladi, Wang, Cuiling, Rachel Saunders-Pullman, Marta San Luciano, Cuiling Wang, Roberto A. Ortega, Karen Marder, San Luciano, Marta, Giladi, Nir, Ortega, Roberto A, Susan Bressman, null null, Saunders‐Pullman, Rachel, Consortium, the Michael J Fox Foundation LRRK2, Marder, Karen, Bressman, Susan   +15 more
core   +1 more source

Dynamic and redundant regulation of LRRK2 and LRRK1 expression

BMC Neuroscience, 2007
Background Mutations within the leucine-rich repeat kinase 2 (LRRK2) gene account for a significant proportion of autosomal-dominant and some late-onset sporadic Parkinson's disease. Elucidation of LRRK2 protein function in health and disease provides an
Dawson Ted M, Dawson Valina L, Coombes Candice E, Lorenz-Deperieux Bettina, Rea Alexis, Moore Darren J, Biskup Saskia, West Andrew B   +7 more
doaj   +1 more source

LRRK2 Regulates CPT1A to Promote β-Oxidation in HepG2 Cells

Molecules, 2020
Leucine-rich repeat kinase 2 (LRRK2) is involved in lipid metabolism; however, the role of LRRK2 in lipid metabolism to affect non-alcoholic fatty liver disease (NAFLD) is still unclear. In the mouse model of NAFLD induced by a high-fat diet, we observed
Chiao-Wei Lin, Yu-Ju Peng, Yuan-Yu Lin, Harry John Mersmann, Shih-Torng Ding   +4 more
doaj   +1 more source

Evaluation of Current Methods to Detect Cellular Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Activity

Journal of Parkinson’s Disease, 2022
Background: Coding variation in the Leucine rich repeat kinase 2 gene linked to Parkinson’s disease (PD) promotes enhanced activity of the encoded LRRK2 kinase, particularly with respect to autophosphorylation at S1292 and/or phosphorylation of the ...
Belén Fernández, Vinita G. Chittoor-Vinod, Jillian H. Kluss, Kaela Kelly, Nicole Bryant, An Phu Tran Nguyen, Syed A. Bukhari, Nathan Smith, Antonio Jesús Lara Ordóñez, Elena Fdez, Marie-Christine Chartier-Harlin, Thomas J. Montine, Mark A. Wilson, Darren J. Moore, Andrew B. West, Mark R. Cookson, R. Jeremy Nichols, Sabine Hilfiker   +17 more
doaj   +1 more source

The function of Golgi apparatus in LRRK2-associated Parkinson’s disease

Frontiers in Molecular Neuroscience, 2023
Parkinson’s disease (PD) is a chronic neurodegenerative disease associated with the intracellular organelles. Leucine-rich repeat kinase 2 (LRRK2) is a large multi-structural domain protein, and mutation in LRRK2 is associated with PD.
Yonghang Wei, Maher un Nisa Awan, Liping Bai, Jie Bai   +3 more
doaj   +1 more source

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif, Diane Demailly, Gabriella A. Horvàth, Juan Dario Ortigoza Escobar, Nathalie Dorison, Mayté Castro Jiménez, Cécile A. Hubsch, Thomas Wirth, Gun‐Marie Hariz, Sophie Huby, Morgan Dornadic, Zohra Souei, Muhammad Mushhood Ur Rehman, Simone Hemm, Mehdi Boulaymen, Eduardo M. Moraud, Jocelyne Bloch, Xavier Vasques   +17 more
wiley   +1 more source

ArfGAP1 Is a GTPase Activating Protein for LRRK2: Reciprocal Regulation of ArfGAP1 by LRRK2 [PDF]

The Journal of Neuroscience, 2012
Both sporadic and autosomal dominant forms of Parkinson's disease (PD) have been causally linked to mutations in leucine-rich repeat kinase 2 (LRRK2), a large protein with multiple domains. The kinase domain plays an important role in LRRK2-mediated toxicity. Although a number of investigations have focused on LRRK2 kinase activity, less is known about
Yulan, Xiong, Changqing, Yuan, Rong, Chen, Ted M, Dawson, Valina L, Dawson   +4 more
openaire   +2 more sources

The emerging role of LRRK2 in tauopathies

Clinical Science, 2022
Abstract Parkinson’s disease (PD) is conventionally described as an α-synuclein aggregation disorder, defined by Lewy bodies and neurites, and mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common autosomal dominant cause of PD. However, LRRK2 mutations may be associated with diverse pathologies in patients with Parkinson’
Susanne Herbst, Patrick A. Lewis, Huw R. Morris   +2 more
openaire   +3 more sources