Results 1 to 10 of about 21,742 (223)

Health Technology Assessment of Cardiopulmonary Bypass Circuit with and without Phosphorylcholine Coating: A Retrospective Study on Safety and Efficiency in Cardiac Surgery. [PDF]

Life (Basel)
Background: Phosphorylcholine has emerged as a potential adjunctive agent in cardiopulmonary bypass (CPB) circuits. Phosphorylcholine serves as a coating for the CPB circuit, potentially enhancing biocompatibility and reducing thrombotic events. However,
Condello I, Nasso G, Scrivo S, Fiore F, Speziale G.   +4 more
europepmc   +2 more sources

A Prussian Blue Nanozyme-Adjuvanted Vaccine Presenting Phosphocholine Antigens for Induction of Immunotolerance in Inflammatory Bowel Disease. [PDF]

Adv Sci (Weinh)
Inflammatory bowel disease (IBD) is a complex disorder characterized by chronic intestinal inflammation and impaired barrier function, for which effective long‐term therapies remain elusive.
Sheng J, Huang Y, Li X, Liu Y, Wu Y, Zhang Y, Gu N.   +6 more
europepmc   +2 more sources

Enhanced anti-microbial properties of clear aligner resin containing zwitterionic material. [PDF]

Sci Rep
This study evaluated the mechanical and anti-bacterial properties of photocurable clear aligner resin (TC-85) incorporated with zwitterionic material, 2-methacryloyloxyethyl phosphorylcholine (MPC).
Paik Y, Kim YM, Choi YK, Kim SH, Kim SS, Kim W, Kim YI.   +6 more
europepmc   +2 more sources

A Universal and Versatile Zwitterionic Coating for Blood-Contacting Catheters with Long Lengths and Complex Geometries. [PDF]

Adv Sci (Weinh)
Blood‐contacting catheters are highly susceptible to thrombus formation, making heparin coating essential for reducing clinical complications. However, the limitations of heparin coatings have spurred significant efforts to develop alternative strategies.
Zhang T, Liang T, Pan Q, Zhang S, Zhang S, Geng Z, Zhu B.   +6 more
europepmc   +2 more sources

MgaSpn is a negative regulator of capsule and phosphorylcholine biosynthesis and influences the virulence of Streptococcus pneumoniae D39

Virulence, 2021
Global transcriptional regulators are prevalent in gram-positive pathogens. The transcriptional regulators of the Mga/AtxA family regulate target gene expression by directly binding to the promoter regions, that results in the coordinated expression of ...
Shengnan Xiao, Weicai Suo, Jinghui Zhang, Xuemei Zhang, Yibing Yin, Xinlin Guo, Yuqiang Zheng   +6 more
doaj   +1 more source

Impact of Phosphorylcholine Expression on the Adherence and Invasion of Streptococcus pyogenes to Epithelial Cells

Microorganisms, 2022
Phosphorylcholine (PC) is a structural component of various pathogens and is involved in bacterial adhesion via the platelet-activating factor receptor (PAF-R).
Hiroyuki Iuchi, Junichiro Ohori, Hisahiro Matsuzaki, Takeshi Tokushige, Sakiko Toge, Masaru Yamashita   +5 more
doaj   +1 more source

The Influence of a Conjugated Pneumococcal Vaccination on Plasma Antibody Levels against Oxidized Low-Density Lipoprotein in Metabolic Disease Patients: A Single-Arm Pilot Clinical Trial

Antioxidants, 2021
As a mediator between lipid metabolism dysfunction, oxidative stress and inflammation, oxidized low-density lipoprotein (oxLDL) is a promising therapeutical target in a wide range of metabolic diseases.
Ronit Shiri-Sverdlov, Inês Magro dos Reis, Yvonne Oligschlaeger, Tim Hendrikx, Dennis M. Meesters, Annick Vanclooster, Nele Vanhoutvin, Ger H. Koek, Marit Westerterp, Christoph J. Binder, David Cassiman, Tom Houben   +11 more
doaj   +1 more source

Analysis of Bacterial Phosphorylcholine-Related Genes Reveals an Association between Type-Specific Biosynthesis Pathways and Biomolecules Targeted for Phosphorylcholine Modification

Microbiology Spectrum, 2023
Many bacterial surface proteins and carbohydrates are modified with phosphorylcholine (ChoP), which contributes to host mimicry and can also promote colonization and survival in the host. However, the ChoP biosynthetic pathways that are used in bacterial
Yuan Zhang, Freda E.-C. Jen, Jennifer L. Edwards, Michael P. Jennings   +3 more
doaj   +1 more source

Antibodies against Phosphorylcholine—Implications for Chronic Inflammatory Diseases

Metabolites, 2023
Atherosclerosis and its main consequence, cardiovascular disease (CVD) are nowadays regarded as chronic inflammatory disease conditions, and CVD is the main cause of death in the world.
Johan Frostegård
doaj   +1 more source

Inhibitory effects of 2-methacryloyloxyethyl phosphorylcholine polymer on the adherence of bacteria causing upper respiratory tract infection

Journal of Oral Microbiology, 2020
Objective We aimed to investigate the inhibitory effect of 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer on the adherence of Streptococcus pneumoniae (Spn) and nontypeable Haemophilus influenzae (NTHi) in vitro and in vivo. Materials and Methods
Hiroyuki Iuchi, Junichiro Ohori, Takayuki Kyutoku, Kotoko Ito, Masaki Kawabata   +4 more
doaj   +1 more source