Results 141 to 150 of about 5,158 (158)

Targeting amino acid in tumor therapy. [PDF]

Front Oncol
Ge M, Xu Y, Cui L, Huang E, Liu Z, Yin K.   +5 more
europepmc   +1 more source

IMP metabolic mechanisms and IMPDH targeting strategies in tumor metabolic reprogramming and therapy (Review). [PDF]

Int J Mol Med
Zhu H, Wang H, Li X, Zhang W, Wang Y, Tan Q, Ying D, Shi Z, Song J.   +8 more
europepmc   +1 more source

Comprehensive analysis of the microbial consortium in the culture of flagellate Monocercomonoides exilis. [PDF]

Environ Microbiome
Jiménez-González A, Treitli SC, Peña-Diaz P, Janovská A, Beneš V, Žáček P, Hampl V.   +6 more
europepmc   +1 more source

Inborn Errors of Amino Acid Metabolism Revisited: Clinical Implications and Insights into Current Therapies. [PDF]

J Clin Med
Shakerdi AL, Nerney D, Molloy EJ, Knerr I.   +3 more
europepmc   +1 more source

Modulating the serine metabolism in human differentiated astrocytes: an integrated multi omics approach. [PDF]

Front Cell Neurosci
Tripodi F, Maffioli E, Sacchi S, Rabattoni V, Motta Z, Bearzi C, Tedeschi G, Pollegioni L, Coccetti P.   +8 more
europepmc   +1 more source

Time-specific study on the efficacy of stems and leaves of <i>Arachis hypogaea</i> L. targeting glycine/serine metabolism for insomnia treatment. [PDF]

J Pharm Anal
Wang Y, Huang Y, Wang G, Jiang T, Geng S, Xu H, Zhou T, Zhang W.   +7 more
europepmc   +1 more source

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Phosphoserine Aminotransferase 1: A Metabolic Enzyme Target of Cancers

Current Cancer Drug Targets, 2023
Abstract: Phosphoserine aminotransferase 1 (PSAT1) catalyzes 3-phosphohydroxylpyruvate and glutamate into 3-phosphoserine and α-ketoglutamate. It integrates metabolic pathways critical for cell proliferation, survival, migration and epigenetics, such as glycolysis, de novo serine synthesis, citric acid cycle and one-carbon metabolism.
Yuping Chen, Xue Yang, Chaojie Li
openaire   +2 more sources

Downregulation of Phosphoserine aminotransferase 1 promotes tumorigenesis in Glioblastoma

The FASEB Journal, 2020
Glioblastoma (GBM) is a typical brain tumor with survival below ten percent at 5 years after diagnosis. The genetic alternation and histological features are integrated into the classification of gliomas for better clinical management of GBM.
Yung-chieh Chan, Shang-Pen Huang, Yu-Chan Chang, Michael Hsiao   +3 more
openaire   +1 more source

Abstract 1435: Investigation of phosphoserine aminotransferase 1: Its role in breast cancer progression

Cancer Research, 2018
Abstract Metastasis and endocrine resistance are two factors that complicate therapeutic intervention in breast cancer patients and lead to poorer overall survival. Metastasis is known to be responsible for 90% of cancer related deaths, and is especially prevalent in triple negative breast cancer (TNBC); while endocrine resistance can ...
Stephanie Metcalf, Traci Kruer, James Wittliff, Carolyn Klinge, Brian F. Clem   +4 more
openaire   +1 more source

Abstract 1163: Phosphoserine aminotransferase 1 (PSAT1) as a novel anti-tumor target in hepatocellular carcinoma

Cancer Research, 2015
Abstract With an estimated 700,000 new cases per year, hepatocellular carcinoma (HCC) represents the fifth commonest cancer and is the third leading cause of cancer death worldwide. Its 5-year survival rate after surgery is only 5-6%.
Zhaobing Ding, Kenneth Wee, Eung-Sam Kim, Animesh Samanta, Michael Steckel, Marian Raschke, Sendhil Velan, Young-Tae Chang, Andrea Haegebarth, Karl Ziegelbauer, Sylvia Gruenewald, Weiping Han   +11 more
openaire   +1 more source