Results 1 to 10 of about 3,887 (161)

PSAT1 inhibits ferroptosis in osteosarcoma cells by activating the Xct/GPX4 signaling axis [PDF]

Scientific Reports
Osteosarcoma is a prevalent primary malignant bone tumor predominantly affecting children and adolescents, characterized by a poor survival rate and prognosis. Currently, ferroptosis is a newly defined form of cell death, but the mechanism between it and
Jin Zeng, Haibo Zhan
exaly   +5 more sources

PSAT1 Promotes Metastasis via p-AKT/SP1/ITGA2 Axis in Estrogen Receptor-Negative Breast Cancer Cell

Biomolecules
Background: Accumulating evidence indicates that PSAT1 not only reprogrammed metabolic function but also exhibits “moonlighting” functions in promoting tumor malignancy.
Da Pang, Jianyu Wang, Song Gao
exaly   +4 more sources

Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells [PDF]

Molecular Cancer, 2008
Background Colorectal cancer (CRC) is one of the most common causes of cancer death throughout the world. In this work our aim was to study the role of the phosphoserine aminotransferase PSAT1 in colorectal cancer development.
Bruno Robert, Nicole Bec, Céline Gongora   +2 more
exaly   +4 more sources

Bioinformatics‐based discovery of the involvement of PSAT1 in mediating the anti‐lung adenocarcinoma activity of triptolide [PDF]

Animal Models and Experimental Medicine
Background Triptolide (TP) exhibits various pharmacological activities. Our previous studies have confirmed the efficacy of TP against lung adenocarcinoma (LUAD). However, the potent pharmacological activity of TP is underpinned by its complex mechanisms.
Zhiwen Cao, Lulu Zhang, Wenqiang Zhang, Rong Wan, Xiaogang Peng, Jinyan Xie, Ruru Bai, Jiejing Jin, Changqi Shi, Lan Yan, Xiangyu Guo, Yang Shen, Cheng Lu   +12 more
doaj   +4 more sources

Stabilization of Notch1 and β-catenin in response to ER- breast cancer-specific up-regulation of PSAT1 mediates distant metastasis

Translational Oncology, 2022
Breast cancer has the highest incidence in women worldwide, with a mortality rate second only to lung cancer. Distant metastasis is the major cause of breast cancer-induced death.
Guosheng Ren, Lei Liu, Shuxuan Zhu
exaly   +3 more sources

PSAT1 Promotes NSCLC Progression via the De Novo Serine Synthesis Pathway and Represents a Therapeutic Vulnerability [PDF]

Cancer Medicine
Background Non‐small cell lung cancer (NSCLC) is a malignant tumor characterized by high morbidity and mortality, as well as metabolic reprogramming. Enhanced serine synthesis plays a crucial role in the aberrant metabolism of NSCLC.
Xijia Zhou, Min Zhao, Yingshu Cao, Xiangyu Zhou, Ke Wang   +4 more
doaj   +2 more sources

Cancer-immunity cycle-based molecular subtypes in breast cancer predict the response to immune checkpoint inhibitors [PDF]

Cancer Biology & Medicine
Objective: The cancer-immunity cycle (CIC) outlines key steps of anti-tumor immunity from antigen release to T cell effector function. A comprehensive evaluation of the CIC in patients with breast cancer is lacking, which limits the accurate assessment ...
Di Shao, Tianjian Yu, Yi Xiao, Zhiming Shao   +3 more
doaj   +2 more sources

Dietary sulfur amino acid restriction improves glucose homeostasis through hepatic de novo serine synthesis [PDF]

Molecular Metabolism
Dietary sulfur amino acid restriction (SAAR) improves whole-body glucose homeostasis, elevates liver insulin action, and lowers liver triglycerides. These adaptations are associated with an increased expression of hepatic de novo serine synthesis enzymes,
Andres F. Ortega, Cha Mee Vang, Ferrol I. Rome, Kaitlyn M. Andreoni, Aiden M. Phoebe, Alisa B. Nelson, Peter A. Crawford, James J. Galligan, Stanley Ching-Cheng Huang, Curtis C. Hughey   +9 more
doaj   +2 more sources

Macrophage-to-myofibroblast transition-derived itaconate promotes bone metastasis in lung cancer through targeting of HSPA8 [PDF]

Experimental and Molecular Medicine
Lung cancer bone metastasis carries a poor prognosis, yet the metabolic determinants driving tumour–stroma crosstalk remain largely elusive. Despite extensive investigations into itaconate, a prominent immunometabolite implicated in macrophage ...
Jin Qian, Zhidan Tan, Jinfeng Wang, Tiantian Wei, Chongquan Huang, Shi Cheng, Guoqing Zhong, Huizhen Zou, Xia Kang, Linchong Sun, Yu Zhang   +10 more
doaj   +2 more sources

Tree shrew model of early diabetic retinopathy reveals microvascular dysfunction and identifies phosphoserine aminotransferase 1 as a novel therapeutic target [PDF]

Animal Models and Experimental Medicine
Background Diabetic retinopathy (DR) is the most significant manifestation of diabetic microangiopathy. The existing tree shrew model of DR has dysfunctional retinal short wave sensitivity (SWS) cones and retinal ganglion cells, but it remains unclear ...
Min Qiu, Shurui Huo, Wenguang Wang, Na Li, Qingwei Zeng, Xiaomei Sun, Jiejie Dai, Pinfen Tong, Yuanyuan Han, Ling Zhao, Caixia Lu   +10 more
doaj   +2 more sources