PSAT1 inhibits ferroptosis in osteosarcoma cells by activating the Xct/GPX4 signaling axis [PDF]
Scientific ReportsOsteosarcoma is a prevalent primary malignant bone tumor predominantly affecting children and adolescents, characterized by a poor survival rate and prognosis. Currently, ferroptosis is a newly defined form of cell death, but the mechanism between it and
Zeng Jin
exaly +5 more sources
An integrated pan-cancer analysis of PSAT1: A potential biomarker for survival and immunotherapy
Frontiers in Genetics, 2022 Phosphoserine aminotransferase 1 (PSAT1) may be an oncogene that plays an important role in various cancer types. However, there are still many gaps in the expression of PSAT1 gene and its biological impact in different types of tumors.
Fengfeng Xu +2 more
exaly +5 more sources
PSAT1 Promotes NSCLC Progression via the De Novo Serine Synthesis Pathway and Represents a Therapeutic Vulnerability [PDF]
Cancer MedicineBackground Non‐small cell lung cancer (NSCLC) is a malignant tumor characterized by high morbidity and mortality, as well as metabolic reprogramming. Enhanced serine synthesis plays a crucial role in the aberrant metabolism of NSCLC.
Xijia Zhou +4 more
doaj +3 more sources
PSAT1 Promotes Metastasis via p-AKT/SP1/ITGA2 Axis in Estrogen Receptor-Negative Breast Cancer Cell
BiomoleculesBackground: Accumulating evidence indicates that PSAT1 not only reprogrammed metabolic function but also exhibits “moonlighting” functions in promoting tumor malignancy.
Da Pang, Siyu Wang, Jianyu Wang
exaly +4 more sources
PSAT1 regulates hair follicle growth and stem cell behavior in cashmere goats [PDF]
BMC Veterinary ResearchBackground The Arbas Cashmere Goat from Inner Mongolia is renowned for its superior-quality cashmere, which is primarily produced by secondary hair follicles (SHFs).
Xiao-yu Han +11 more
doaj +4 more sources
Translational Oncology, 2022 Breast cancer has the highest incidence in women worldwide, with a mortality rate second only to lung cancer. Distant metastasis is the major cause of breast cancer-induced death.
Guosheng Ren, Lei Liu, Shuxuan Zhu
exaly +3 more sources
Serine Ameliorates Cadmium-Induced Testicular Injury by Regulating the PGAM1/PHGDH Signaling Pathway. [PDF]
J Biochem Mol ToxicolSerine mitigates cadmium‐induced testicular injury in mice by inhibiting the PGAM1/PHGDH pathway, restoring ion homeostasis and glycolysis, and relieving oxidative stress, inflammation, fibrosis, and apoptosis. ABSTRACT Cadmium (Cd) is a widespread environmental contaminant that impairs male reproductive function; however, the metabolic mechanisms ...
Wang X +8 more
europepmc +2 more sources
Cancer-immunity cycle-based molecular subtypes in breast cancer predict the response to immune checkpoint inhibitors [PDF]
Cancer Biology & MedicineObjective: The cancer-immunity cycle (CIC) outlines key steps of anti-tumor immunity from antigen release to T cell effector function. A comprehensive evaluation of the CIC in patients with breast cancer is lacking, which limits the accurate assessment ...
Di Shao +3 more
doaj +2 more sources
Dietary sulfur amino acid restriction improves glucose homeostasis through hepatic de novo serine synthesis [PDF]
Molecular MetabolismDietary sulfur amino acid restriction (SAAR) improves whole-body glucose homeostasis, elevates liver insulin action, and lowers liver triglycerides. These adaptations are associated with an increased expression of hepatic de novo serine synthesis enzymes,
Andres F. Ortega +9 more
doaj +2 more sources
Tree shrew model of early diabetic retinopathy reveals microvascular dysfunction and identifies phosphoserine aminotransferase 1 as a novel therapeutic target [PDF]
Animal Models and Experimental MedicineBackground Diabetic retinopathy (DR) is the most significant manifestation of diabetic microangiopathy. The existing tree shrew model of DR has dysfunctional retinal short wave sensitivity (SWS) cones and retinal ganglion cells, but it remains unclear ...
Min Qiu +10 more
doaj +2 more sources