Results 1 to 10 of about 3,302 (118)

PSAT1 Promotes NSCLC Progression via the De Novo Serine Synthesis Pathway and Represents a Therapeutic Vulnerability [PDF]

Cancer Medicine
Background Non‐small cell lung cancer (NSCLC) is a malignant tumor characterized by high morbidity and mortality, as well as metabolic reprogramming. Enhanced serine synthesis plays a crucial role in the aberrant metabolism of NSCLC.
Xijia Zhou, Min Zhao, Yingshu Cao, Xiangyu Zhou, Ke Wang   +4 more
doaj   +3 more sources

Tree shrew model of early diabetic retinopathy reveals microvascular dysfunction and identifies phosphoserine aminotransferase 1 as a novel therapeutic target [PDF]

Animal Models and Experimental Medicine
Background Diabetic retinopathy (DR) is the most significant manifestation of diabetic microangiopathy. The existing tree shrew model of DR has dysfunctional retinal short wave sensitivity (SWS) cones and retinal ganglion cells, but it remains unclear ...
Min Qiu, Shurui Huo, Wenguang Wang, Na Li, Qingwei Zeng, Xiaomei Sun, Jiejie Dai, Pinfen Tong, Yuanyuan Han, Ling Zhao, Caixia Lu   +10 more
doaj   +3 more sources

PSAT1 inhibits ferroptosis in osteosarcoma cells by activating the Xct/GPX4 signaling axis [PDF]

Scientific Reports
Osteosarcoma is a prevalent primary malignant bone tumor predominantly affecting children and adolescents, characterized by a poor survival rate and prognosis. Currently, ferroptosis is a newly defined form of cell death, but the mechanism between it and
Jin Zeng, Zeng Jin, Liang Tao
exaly   +3 more sources

An integrated pan-cancer analysis of PSAT1: A potential biomarker for survival and immunotherapy

Frontiers in Genetics, 2022
Phosphoserine aminotransferase 1 (PSAT1) may be an oncogene that plays an important role in various cancer types. However, there are still many gaps in the expression of PSAT1 gene and its biological impact in different types of tumors.
Mingtao Feng, Fengfeng Xu, Yiqun Cao
exaly   +3 more sources

Stabilization of Notch1 and β-catenin in response to ER- breast cancer-specific up-regulation of PSAT1 mediates distant metastasis

Translational Oncology, 2022
Breast cancer has the highest incidence in women worldwide, with a mortality rate second only to lung cancer. Distant metastasis is the major cause of breast cancer-induced death.
Shuxuan Zhu, Lei Liu, Guosheng Ren
exaly   +3 more sources

Dietary sulfur amino acid restriction improves glucose homeostasis through hepatic de novo serine synthesis [PDF]

Molecular Metabolism
Dietary sulfur amino acid restriction (SAAR) improves whole-body glucose homeostasis, elevates liver insulin action, and lowers liver triglycerides. These adaptations are associated with an increased expression of hepatic de novo serine synthesis enzymes,
Andres F. Ortega, Cha Mee Vang, Ferrol I. Rome, Kaitlyn M. Andreoni, Aiden M. Phoebe, Alisa B. Nelson, Peter A. Crawford, James J. Galligan, Stanley Ching-Cheng Huang, Curtis C. Hughey   +9 more
doaj   +2 more sources

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione-Mediated Stemness Maintenance. [PDF]

Adv Sci (Weinh)
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Li Z, Meng C, Shen G, Shan Y, Wang J, Abudukeremu D, Zhao R, Ni B, Xu C, Guo X, Yu J, Wang K, Yang S, Li Y, Xie Y, Zhou T, Hao J, Wang X.   +17 more
europepmc   +2 more sources

PSAT1 is regulated by ATF4 and enhances cell proliferation via the GSK3β/β-catenin/cyclin D1 signaling pathway in ER-negative breast cancer

Journal of Experimental and Clinical Cancer Research, 2017
Background A growing amount of evidence has indicated that PSAT1 is an oncogene that plays an important role in cancer progression and metastasis. In this study, we explored the expression and function of PSAT1 in estrogen receptor (ER)-negative breast ...
Anqi Ge, Shouping Xu, Zilong You
exaly   +3 more sources

Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells

Molecular Cancer, 2008
Background Colorectal cancer (CRC) is one of the most common causes of cancer death throughout the world. In this work our aim was to study the role of the phosphoserine aminotransferase PSAT1 in colorectal cancer development.
Nadia Vie, Nicole Bec, Bruno Robert
exaly   +3 more sources

PSAT1 Promotes Metastasis via p-AKT/SP1/ITGA2 Axis in Estrogen Receptor-Negative Breast Cancer Cell

Biomolecules
Background: Accumulating evidence indicates that PSAT1 not only reprogrammed metabolic function but also exhibits “moonlighting” functions in promoting tumor malignancy.
Xingda Zhang, Jianyu Wang, Yajie Gong
exaly   +3 more sources