Results 1 to 10 of about 22,135,367 (247)

Characterization of RNA content in individual phase-separated coacervate microdroplets

Nature Communications, 2022
Here, the authors demonstrate that single cell RNA sequencing technology can be leveraged to characterize RNA content of individual membrane-free condensates formed by liquid-liquid phase separation processes such as coacervation.
Damian Wollny, Benjamin Vernot, Jie Wang, Maria Hondele, Aram Safrastyan, Franziska Aron, Julia Micheel, Zhisong He, Anthony Hyman, Karsten Weis, J. Gray Camp, T.‐Y. Dora Tang, Barbara Treutlein   +12 more
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RNA-protein interaction prediction without high-throughput data: An overview and benchmark of in silico tools

Computational and Structural Biotechnology Journal
RNA-protein interactions (RPIs) are crucial for accurately operating various processes in and between organisms across kingdoms of life. Mutual detection of RPI partner molecules depends on distinct sequential, structural, or thermodynamic features ...
Sarah Krautwurst, Kevin Lamkiewicz
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Comparative transcriptomics identifies candidate genes involved in the evolutionary transition from dehiscent to indehiscent fruits in Lepidium (Brassicaceae)

BMC Plant Biology, 2022
Background Fruits are the seed-bearing structures of flowering plants and are highly diverse in terms of morphology, texture and maturation. Dehiscent fruits split open upon maturation to discharge their seeds while indehiscent fruits are dispersed as a ...
Lydia Gramzow, Katharina Klupsch, Noé Fernández-Pozo, Martin Hölzer, Manja Marz, Stefan A. Rensing, Günter Theißen   +6 more
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Seasonality of endemic COVID-19

mBio, 2023
Successive waves of infection by SARS-CoV-2 have left little doubt that this virus will transition to an endemic disease. Foreknowledge of when to expect seasonal surges is crucial for healthcare and public health decision-making.
Jeffrey P. Townsend, Hayley B. Hassler, April D. Lamb, Pratha Sah, Aia Alvarez Nishio, Cameron Nguyen, Alexandra D. Tew, Alison P. Galvani, Alex Dornburg   +8 more
doaj   +1 more source

Temporal Profiling of SARS-CoV-2 Variants Using BioEnrichPy: A Network-Based Insight into Host Disruption and Neurodegeneration

COVID
SARS-CoV-2, the virus responsible for COVID-19, disrupts human cellular pathways through complex protein–protein interaction, contributing to disease progression. As the virus has evolved, emerging variants have exhibited differences in transmissibility,
Sreelakshmi Kalayakkattil, Ananthakrishnan Anil Indu, Punya Sunil, Haritha Nekkanti, Smitha Shet, Ranajit Das   +5 more
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Unraveling mitotic protein networks by 3D multiplexed epitope drug screening

Molecular Systems Biology, 2018
Three‐dimensional protein localization intricately determines the functional coordination of cellular processes. The complex spatial context of protein landscape has been assessed by multiplexed immunofluorescent staining or mass spectrometry, applied to
Lorenz J Maier, Stefan M Kallenberger, Katharina Jechow, Marcel Waschow, Roland Eils, Christian Conrad   +5 more
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Dynamic Proteomic Analysis of Pancreatic Mesenchyme Reveals Novel Factors That Enhance Human Embryonic Stem Cell to Pancreatic Cell Differentiation

Stem Cells International, 2016
Current approaches in human embryonic stem cell (hESC) to pancreatic beta cell differentiation have largely been based on knowledge gained from developmental studies of the epithelial pancreas, while the potential roles of other supporting tissue ...
Holger A. Russ, Limor Landsman, Christopher L. Moss, Roger Higdon, Renee L. Greer, Kelly Kaihara, Randy Salamon, Eugene Kolker, Matthias Hebrok   +8 more
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Evaluating and Improving Automatic Sleep Spindle Detection by Using Multi-Objective Evolutionary Algorithms

Frontiers in Human Neuroscience, 2017
Sleep spindles are brief bursts of brain activity in the sigma frequency range (11–16 Hz) measured by electroencephalography (EEG) mostly during non-rapid eye movement (NREM) stage 2 sleep.
Min-Yin Liu, Adam Huang, Norden E. Huang, Norden E. Huang   +3 more
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Nanopore sequencing-derived methylation biomarker prediction for methylation-specific PCR in patients with head and neck squamous cell carcinoma

Clinical Epigenetics
Background DNA methylation of CpG islands is altered in cancer cells. Hypermethylation of single CpG islands in the promoter regions of tumor-suppressor genes occurs already in the early stages of cancer.
Daria Meyer, Anne Hennig, Anna-Bawany Hums, Orlando Guntinas-Lichius, Martina Schmitz, Manja Marz   +5 more
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Methylation Sensitive Amplification Polymorphism Sequencing (MSAP-Seq)—A Method for High-Throughput Analysis of Differentially Methylated CCGG Sites in Plants with Large Genomes

Frontiers in Plant Science, 2017
Epigenetic mechanisms, including histone modifications and DNA methylation, mutually regulate chromatin structure, maintain genome integrity, and affect gene expression and transposon mobility.
Karolina Chwialkowska, Urszula Korotko, Joanna Kosinska, Iwona Szarejko, Miroslaw Kwasniewski   +4 more
doaj   +1 more source