Results 31 to 40 of about 23,754,274 (255)

Guide to Metabolomics Analysis: A Bioinformatics Workflow

, 2022
Metabolomics is an emerging field that quantifies numerous metabolites systematically. The key purpose of metabolomics is to identify the metabolites corresponding to each biological phenotype, and then provide an analysis of the mechanisms involved ...
En-Min Li, Li-Yan Xu, Yang Chen
core   +1 more source

InCoB2014: Bioinformatics to tackle the data to knowledge challenge [PDF]

, 2014
Since 2006, the International Conference on Bioinformatics (InCoB) has been publishing selected papers in BMC Bioinformatics. Papers within the scope of the journal from the 13th InCoB July 31-2 August, 2014 in Sydney, Australia have been compiled in ...
Ranganathan, Shoba, Tan, Tin Wee, Schönbach, Christian, Ranganathan S., Shoba Ranganathan, Christian Schönbach, Schönbach C., Tin Tan, Tan T.W.   +8 more
core   +1 more source

The Helmholtz Network for Bioinformatics: an integrative web portal for bioinformatics resources

, 2022
S.268-270The Helmholtz Network for Bioinformatics (HNB) is a joint venture of eleven German bioinformatics research groups that offers convenient access to numerous bioinformatics resources through a single web portal.
Crass, T., Christensen, M., Claussen, H., Antes, I., Basekow, W., Bork, P., Buning, C., Gailus-Durner, V., Ernst, P., Ebeling, C.   +9 more
core   +1 more source

Bioinformatics [PDF]

, 2012
Motivation: The sequence alignment/map (SAM) and the binary alignment/map (BAM) formats have become the standard method of representation of nucleotide sequence alignments for next-generation sequencing data.
Tarazona, Sonia, Okonechnikov, Konstantin, Tarazona, S., García-Alcalde, F., Dopazo, J., Dopazo, Joaquín, Götz, S., Cruz, L., Meyer, T., Carbonell Caballero, José, Conesa, Ana, Carbonell, J., Conesa, A., Okonechnikov, K., Meyer, Thomas F., GOTZ, STEFAN, García-Alcalde, Fernando, Cruz, Luís M.   +17 more
core   +1 more source

Exploring the impact of primer length on efficient gene detection via high-throughput sequencing

Nature Communications
Reverse transcription (RT) is a crucial step in most RNA analysis methods. Optimizing protocols for this initial stage is critical for effective target detection, particularly when working with limited input RNA.
Julia Micheel, Aram Safrastyan, Franziska Aron, Damian Wollny   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

GBCdb: RNA expression landscapes and ncRNA–mRNA interactions in gallbladder carcinoma

BMC Bioinformatics, 2023
Gallbladder carcinoma (GBC), an aggressive malignant tumor of the biliary system, is characterized by high cellular heterogeneity and poor prognosis. Fewer data have been reported in GBC than other common cancer types. Multi-omics data will contribute to
Li Guo, Yangyang Xiang, Yuyang Dou, Zibo Yin, Xinru Xu, Lihua Tang, Jiafeng Yu, Jun Wang, Tingming Liang   +8 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Bioinformatics

, 2019
Our bioinformatic staff consist of PhD-level scientists trained in computer languages, statistics, bioinformatics, genetics, and genomics. The software infrastructure for analysis is a combination of custom-built and open-source software.
Grace Melly (5914202)
core   +1 more source