Scientific Reports, 2023 Phosphoserine aminotransferase 1 (PSAT1) has been associated with the occurrence and development of various carcinomas; however, its function in uterine corpus endometrial carcinoma (UCEC) is unknown.
Min Wang, Song Yue, Zhu Yang
doaj +3 more sources
Targeting PSAT1 to mitigate metastasis in tumors with p53-72Pro variant
Signal Transduction and Targeted Therapy, 2023 The single-nucleotide polymorphism (SNP) of p53, in particular the codon 72 variants, has recently been implicated as a critical regulator in tumor progression. However, the underlying mechanism remains elusive.
Jingwen Jiang +14 more
doaj +3 more sources
Journal of Experimental & Clinical Cancer Research, 2017 Background A growing amount of evidence has indicated that PSAT1 is an oncogene that plays an important role in cancer progression and metastasis. In this study, we explored the expression and function of PSAT1 in estrogen receptor (ER)-negative breast ...
Song Gao +6 more
doaj +2 more sources
Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells [PDF]
Molecular Cancer, 2008 Background Colorectal cancer (CRC) is one of the most common causes of cancer death throughout the world. In this work our aim was to study the role of the phosphoserine aminotransferase PSAT1 in colorectal cancer development.
Conseiller Emmanuel +12 more
doaj +2 more sources
Elevated PSAT1 expression distinguishes basal-like human breast cancer.
, 2022 Patients diagnosed with basal-like breast cancer face a more aggressive disease course and more dismal prognosis than patients diagnosed with luminal A and luminal B breast cancer molecular subtypes (1-4). We mined published microarray data (5, 6) to understand in an unbiased fashion the most distinguishing transcriptional features of tumors from ...
Shahan Mamoor
openaire +2 more sources
A PSAT1 buff of YBX1 transcriptionally sustains HLA-E-mediated evasion of NK immunity [PDF]
Proceedings of the National Academy of Sciences of the United States of AmericaDespite great success in certain cancers, immunotherapy made little progress in treating immune cold tumors, largely attributed to an immune-suppressive tumor microenvironment with elusive mechanisms. Here, we report in prostate cancer cells a positive feedback loop driven by phosphoserine aminotransferase 1 (PSAT1) that could be targeted to render ...
Chaobing Ma, Gerry Melino
exaly +4 more sources
Functional consequence of PSAT1 association on PKM2's inherent enzymatic activity. [PDF]
, 2019 Pyruvate kinase M2 (PKM2) is predominantly found in tumors, where it allows the cancer cell to adapt to metabolic conditions through allosteric regulation of its activity.
Vega, Alexis Avidan
openaire +3 more sources
Phosphoserine aminotransferase 1 is associated to poor outcome on tamoxifen therapy in recurrent breast cancer [PDF]
Scientific Reports, 2017 In a previous study, we detected a significant association between phosphoserine aminotransferase 1 (PSAT1) hyper-methylation and mRNA levels to outcome to tamoxifen treatment in recurrent disease.
Tommaso De Marchi +12 more
doaj +5 more sources
Histone lactylation-boosted AURKB facilitates colorectal cancer progression by inhibiting HNRNPM-mediated PSAT1 mRNA degradation [PDF]
Journal of Experimental & Clinical Cancer ResearchBackground Aurora kinase B (AURKB), a key regulator of mitosis, is frequently upregulated in various malignancies, including colorectal cancer (CRC), and is associated with poor prognosis.
Yuyi Li +13 more
doaj +2 more sources
Transcriptome Analysis Reveals the Molecular Mechanisms by Which ADAMTS1 Influences the Proliferation of Ovarian Granulosa Cells in Sheep [PDF]
AnimalsNormal proliferation of ovarian granulosa cells is essential for follicular development. The results of this study showed that ADAMTS1 was primarily localized in the cytoplasm of granulosa cells in sheep ovarian follicles, as revealed by ...
Rongqing Li +12 more
doaj +2 more sources