Results 21 to 30 of about 3,665 (185)

Targeting PSAT1 to mitigate metastasis in tumors with p53-72Pro variant

Signal Transduction and Targeted Therapy, 2023
The single-nucleotide polymorphism (SNP) of p53, in particular the codon 72 variants, has recently been implicated as a critical regulator in tumor progression. However, the underlying mechanism remains elusive.
Jingwen Jiang, Hai-Ning Chen, Ping Jin, Li Zhou, Liyuan Peng, Zhao Huang, Siyuan Qin, Bowen Li, Hui Ming, Maochao Luo, Na Xie, Wei Gao, Edouard C. Nice, Qiang Yu, Canhua Huang   +14 more
doaj   +3 more sources

Investigation of phosphoserine aminotransferase 1(PSAT1) in breast cancer progression.

, 2020
This dissertation describes my research into the involvement of phosphoserine aminotransferase 1 (PSAT1) in breast cancer progression; specifically, in triple negative breast cancer (TNBC) metastasis and endocrine resistance in estrogen receptor positive
Metcalf, Stephanie
openaire   +4 more sources

Elevated PSAT1 expression distinguishes basal-like human breast cancer.

, 2022
Patients diagnosed with basal-like breast cancer face a more aggressive disease course and more dismal prognosis than patients diagnosed with luminal A and luminal B breast cancer molecular subtypes (1-4). We mined published microarray data (5, 6) to understand in an unbiased fashion the most distinguishing transcriptional features of tumors from ...
Shahan Mamoor
openaire   +2 more sources

Phosphoserine aminotransferase 1 is associated to poor outcome on tamoxifen therapy in recurrent breast cancer [PDF]

Scientific Reports, 2017
In a previous study, we detected a significant association between phosphoserine aminotransferase 1 (PSAT1) hyper-methylation and mRNA levels to outcome to tamoxifen treatment in recurrent disease.
Tommaso De Marchi, Mieke A. Timmermans, Anieta M. Sieuwerts, Marcel Smid, Maxime P. Look, Nicolai Grebenchtchikov, Fred C. G. J. Sweep, Jan G. Smits, Viktor Magdolen, Carolien H. M. van Deurzen, John A. Foekens, Arzu Umar, John W. Martens   +12 more
doaj   +4 more sources

Histone lactylation-boosted AURKB facilitates colorectal cancer progression by inhibiting HNRNPM-mediated PSAT1 mRNA degradation [PDF]

Journal of Experimental & Clinical Cancer Research
Background Aurora kinase B (AURKB), a key regulator of mitosis, is frequently upregulated in various malignancies, including colorectal cancer (CRC), and is associated with poor prognosis.
Yuyi Li, Jinjin Peng, Di Wu, Qingxin Xie, Yichao Hou, Linjing Li, Xintian Zhang, Yu Liang, Jing Feng, Jiaqing Chen, Wangshuang Chen, Che Xu, Han Yao, Xiangjun Meng   +13 more
doaj   +2 more sources

Interplay between acetylation and ubiquitination controls PSAT1 protein stability in lung adenocarcinoma

Communications Biology
Serine is essential to maintain maximal growth and proliferation of cancer cells by providing adequate intermediate metabolites and energy. Phosphoserine aminotransferase 1 (PSAT1) is a key enzyme in de novo serine synthesis.
Yuhan Liu, Wenze Xun, Tao Zhao, Menglin Huang, Longhua Sun, Guilan Wen, Xiuhua Kang, Jianbin Wang, Tianyu Han   +8 more
doaj   +3 more sources

Transcriptome Analysis Reveals the Molecular Mechanisms by Which ADAMTS1 Influences the Proliferation of Ovarian Granulosa Cells in Sheep [PDF]

Animals
Normal proliferation of ovarian granulosa cells is essential for follicular development. The results of this study showed that ADAMTS1 was primarily localized in the cytoplasm of granulosa cells in sheep ovarian follicles, as revealed by ...
Rongqing Li, Wenjia Zhang, Yuanshuai Gao, Zhiqiang Xie, Jiangfeng He, Qinyuan Fang, Mohamed El-Sherbiny, Min Gao, Zheng Wang, Teng Zhang, Fang Liu, Biao Wang, Yongbin Liu   +12 more
doaj   +2 more sources

Nf1 loss promotes Kras‐driven lung adenocarcinoma and results in Psat1‐mediated glutamate dependence

EMBO Molecular Medicine, 2019
Mutations to KRAS are recurrent in lung adenocarcinomas (LUAD) and are daunting to treat due to the difficulties in KRAS oncoprotein inhibition. A possible resolution to this problem may lie with co‐mutations to other genes that also occur in KRAS‐driven
Xiaojing Wang, Shengping Min, Hongli Liu, Nan Wu, Xincheng Liu, Tao Wang, Wei Li, Yuanbing Shen, Hongtao Wang, Zhongqing Qian, Huanbai Xu, Chengling Zhao, Yuqing Chen   +12 more
doaj   +2 more sources

Functional consequence of PSAT1 association on PKM2's inherent enzymatic activity.

, 2019
Pyruvate kinase M2 (PKM2) is predominantly found in tumors, where it allows the cancer cell to adapt to metabolic conditions through allosteric regulation of its activity.
Vega, Alexis Avidan
openaire   +4 more sources

ΔNp63α drives serine synthesis to promote carboplatin resistance in NSCLC [PDF]

Cell Death and Disease
Serine metabolism is a critical vulnerability in cancer; however, its role in mediating therapeutic resistance in non-small cell lung cancer (NSCLC) remains incompletely understood.
Liyuan Deng, Xin Yang, Junli Zhang, Xuanyu Zhou, Ruidong Ma, Zhiqiang Wu, Hu Chen   +6 more
doaj   +2 more sources