Results 21 to 30 of about 3,887 (161)

Downregulation of PSAT1 inhibits cell proliferation and migration in uterine corpus endometrial carcinoma

Scientific Reports, 2023
Phosphoserine aminotransferase 1 (PSAT1) has been associated with the occurrence and development of various carcinomas; however, its function in uterine corpus endometrial carcinoma (UCEC) is unknown.
Min Wang, Song Yue, Zhu Yang
doaj   +3 more sources

Targeting PSAT1 to mitigate metastasis in tumors with p53-72Pro variant

Signal Transduction and Targeted Therapy, 2023
The single-nucleotide polymorphism (SNP) of p53, in particular the codon 72 variants, has recently been implicated as a critical regulator in tumor progression. However, the underlying mechanism remains elusive.
Jingwen Jiang, Hai-Ning Chen, Ping Jin, Li Zhou, Liyuan Peng, Zhao Huang, Siyuan Qin, Bowen Li, Hui Ming, Maochao Luo, Na Xie, Wei Gao, Edouard C. Nice, Qiang Yu, Canhua Huang   +14 more
doaj   +3 more sources

PSAT1 is regulated by ATF4 and enhances cell proliferation via the GSK3β/β-catenin/cyclin D1 signaling pathway in ER-negative breast cancer

Journal of Experimental & Clinical Cancer Research, 2017
Background A growing amount of evidence has indicated that PSAT1 is an oncogene that plays an important role in cancer progression and metastasis. In this study, we explored the expression and function of PSAT1 in estrogen receptor (ER)-negative breast ...
Song Gao, Anqi Ge, Shouping Xu, Zilong You, Shipeng Ning, Yashuang Zhao, Da Pang   +6 more
doaj   +2 more sources

Elevated PSAT1 expression distinguishes basal-like human breast cancer.

, 2022
Patients diagnosed with basal-like breast cancer face a more aggressive disease course and more dismal prognosis than patients diagnosed with luminal A and luminal B breast cancer molecular subtypes (1-4). We mined published microarray data (5, 6) to understand in an unbiased fashion the most distinguishing transcriptional features of tumors from ...
Shahan Mamoor
openaire   +2 more sources

Functional consequence of PSAT1 association on PKM2's inherent enzymatic activity. [PDF]

, 2019
Pyruvate kinase M2 (PKM2) is predominantly found in tumors, where it allows the cancer cell to adapt to metabolic conditions through allosteric regulation of its activity.
Vega, Alexis Avidan
openaire   +3 more sources

Phosphoserine aminotransferase 1 is associated to poor outcome on tamoxifen therapy in recurrent breast cancer [PDF]

Scientific Reports, 2017
In a previous study, we detected a significant association between phosphoserine aminotransferase 1 (PSAT1) hyper-methylation and mRNA levels to outcome to tamoxifen treatment in recurrent disease.
Tommaso De Marchi, Mieke A. Timmermans, Anieta M. Sieuwerts, Marcel Smid, Maxime P. Look, Nicolai Grebenchtchikov, Fred C. G. J. Sweep, Jan G. Smits, Viktor Magdolen, Carolien H. M. van Deurzen, John A. Foekens, Arzu Umar, John W. Martens   +12 more
doaj   +5 more sources

New insights into PSAT1 as a therapeutic target for myelodysplastic syndrome (MDS).

PLoS ONE
The metabolomic landscape in myelodysplastic syndrome (MDS) is highly deregulated and presents promising avenues for understanding disease pathogenesis and potential molecular dependencies.
Sael Alatawi, Waseem Alzamzami
doaj   +4 more sources

Nf1 loss promotes Kras‐driven lung adenocarcinoma and results in Psat1‐mediated glutamate dependence

EMBO Molecular Medicine, 2019
Mutations to KRAS are recurrent in lung adenocarcinomas (LUAD) and are daunting to treat due to the difficulties in KRAS oncoprotein inhibition. A possible resolution to this problem may lie with co‐mutations to other genes that also occur in KRAS‐driven
Xiaojing Wang, Shengping Min, Hongli Liu, Nan Wu, Xincheng Liu, Tao Wang, Wei Li, Yuanbing Shen, Hongtao Wang, Zhongqing Qian, Huanbai Xu, Chengling Zhao, Yuqing Chen   +12 more
doaj   +2 more sources

Interplay between acetylation and ubiquitination controls PSAT1 protein stability in lung adenocarcinoma

Communications Biology
Serine is essential to maintain maximal growth and proliferation of cancer cells by providing adequate intermediate metabolites and energy. Phosphoserine aminotransferase 1 (PSAT1) is a key enzyme in de novo serine synthesis.
Yuhan Liu, Wenze Xun, Tao Zhao, Menglin Huang, Longhua Sun, Guilan Wen, Xiuhua Kang, Jianbin Wang, Tianyu Han   +8 more
doaj   +3 more sources

Histone lactylation-boosted AURKB facilitates colorectal cancer progression by inhibiting HNRNPM-mediated PSAT1 mRNA degradation [PDF]

Journal of Experimental & Clinical Cancer Research
Background Aurora kinase B (AURKB), a key regulator of mitosis, is frequently upregulated in various malignancies, including colorectal cancer (CRC), and is associated with poor prognosis.
Yuyi Li, Jinjin Peng, Di Wu, Qingxin Xie, Yichao Hou, Linjing Li, Xintian Zhang, Yu Liang, Jing Feng, Jiaqing Chen, Wangshuang Chen, Che Xu, Han Yao, Xiangjun Meng   +13 more
doaj   +2 more sources