Results 11 to 20 of about 3,887 (161)
PSAT1 inhibits mTORC1 activation by preventing Rag heterodimer formation in lung adenocarcinoma [PDF]
AutophagyThe mechanistic target of rapamycin complex 1 (mTORC1) integrates environmental cues, especially amino acids, to regulate metabolism and ultimately cancer progression. Phosphoserine aminotransferase 1 (PSAT1) is a key enzyme in de novo serine synthesis and its overexpression has been reported to promote oncogenesis in various cancers.
Tianyu Han, Jinjin Zhang, Zhujun Cheng
exaly +5 more sources
PSAT1 regulates hair follicle growth and stem cell behavior in cashmere goats [PDF]
BMC Veterinary ResearchBackground The Arbas Cashmere Goat from Inner Mongolia is renowned for its superior-quality cashmere, which is primarily produced by secondary hair follicles (SHFs).
Xiao-yu Han +11 more
doaj +4 more sources
Frontiers in Bioscience-Landmark, 2023 Purpose: Current evidence suggests that phosphoserine aminotransferase 1 (PSAT1) is overexpressed in various tumors. Herein, we investigate the significance of PSAT1 in non-small cell lung cancer (NSCLC) and its correlation with immune infiltration ...
Hongmu Li +8 more
doaj +2 more sources
Differential expression of PSAT1 in pancreatic cancer.
, 2023 Cancer is a leading cause of death and pancreatic cancer is among the most lethal cancers (1, 2). We mined published microarray datasets (3, 4) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with pancreatic cancer, pancreatic adenocarcinoma (PDAC).
Shahan Mamoor
openaire +2 more sources
An integrated pan-cancer analysis of PSAT1: A potential biomarker for survival and immunotherapy
Frontiers in Genetics, 2022 Phosphoserine aminotransferase 1 (PSAT1) may be an oncogene that plays an important role in various cancer types. However, there are still many gaps in the expression of PSAT1 gene and its biological impact in different types of tumors.
Mingtao Feng +10 more
doaj +3 more sources
Journal of Translational Medicine, 2023 Background Periodontal ligament stem cells (PDLSCs) are important seed cells for tissue engineering to realize the regeneration of alveolar bone. Understanding the gene regulatory mechanisms of osteogenic lineage differentiation in PDLSCs will facilitate
Linglu Jia +4 more
doaj +3 more sources
Overexpression of the PSAT1 Gene in Nasopharyngeal Carcinoma Is an Indicator of Poor Prognosis [PDF]
Journal of Cancer, 2016 Nasopharyngeal carcinoma (NPC) is a common cancer in southern China and Southeast Asia, but risk stratification and treatment outcome in NPC patients remain suboptimal. Our study identified and validated metabolic drivers that are relevant to the pathogenesis of NPC using a published transcriptome.
Liao, Kuang-Ming +10 more
openaire +4 more sources
Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma [PDF]
Autophagy, 2019 GBM (glioblastoma multiforme) is the most common and aggressive brain tumor with no curative options available. Therefore, it is imperative to develop novel potent therapeutic drugs for GBM treatment. Here, we show that regorafenib, an oral multi-kinase inhibitor, exhibits superior therapeutic efficacy over temozolomide, the first-line chemotherapeutic
Jingwen Jiang +20 more
openaire +3 more sources
Cellular Physiology and Biochemistry, 2016 Background/Aims: Phosphoserine aminotransferase 1 (PSAT1) is over-expressed in many carcinoma tissues, however little is known regarding its expression and function in esophageal carcinogenesis.
Bingyan Liu +9 more
doaj +2 more sources
Investigation of phosphoserine aminotransferase 1(PSAT1) in breast cancer progression. [PDF]
, 2020 This dissertation describes my research into the involvement of phosphoserine aminotransferase 1 (PSAT1) in breast cancer progression; specifically, in triple negative breast cancer (TNBC) metastasis and endocrine resistance in estrogen receptor positive
Metcalf, Stephanie
openaire +3 more sources