Results 11 to 20 of about 3,801 (180)

Nf1 loss promotes Kras ‐driven lung adenocarcinoma and results in Psat1‐mediated glutamate dependence

EMBO Molecular Medicine, 2019
Mutations to KRAS are recurrent in lung adenocarcinomas (LUAD) and are daunting to treat due to the difficulties in KRAS oncoprotein inhibition. A possible resolution to this problem may lie with co‐mutations to other genes that also occur in KRAS‐driven
Xiaojing Wang, Huanbai Xu
exaly   +3 more sources

Bioinformatics‐based discovery of the involvement of PSAT1 in mediating the anti‐lung adenocarcinoma activity of triptolide [PDF]

Animal Models and Experimental Medicine
Background Triptolide (TP) exhibits various pharmacological activities. Our previous studies have confirmed the efficacy of TP against lung adenocarcinoma (LUAD). However, the potent pharmacological activity of TP is underpinned by its complex mechanisms.
Zhiwen Cao, Lulu Zhang, Wenqiang Zhang, Rong Wan, Xiaogang Peng, Jinyan Xie, Ruru Bai, Jiejing Jin, Changqi Shi, Lan Yan, Xiangyu Guo, Yang Shen, Cheng Lu   +12 more
doaj   +4 more sources

Overexpression of PSAT1 is Correlated with Poor Prognosis and Immune Infiltration in Non-Small Cell Lung Cancer

Frontiers in Bioscience-Landmark, 2023
Purpose: Current evidence suggests that phosphoserine aminotransferase 1 (PSAT1) is overexpressed in various tumors. Herein, we investigate the significance of PSAT1 in non-small cell lung cancer (NSCLC) and its correlation with immune infiltration ...
Hongmu Li, Chun Wu, Wuguang Chang, Leqi Zhong, Wuyou Gao, Mingyue Zeng, Zhesheng Wen, Shijuan Mai, Youfang Chen   +8 more
doaj   +2 more sources

Differential expression of PSAT1 in pancreatic cancer.

, 2023
Cancer is a leading cause of death and pancreatic cancer is among the most lethal cancers (1, 2). We mined published microarray datasets (3, 4) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with pancreatic cancer, pancreatic adenocarcinoma (PDAC).
Shahan Mamoor
openaire   +2 more sources

PSAT1 positively regulates the osteogenic lineage differentiation of periodontal ligament stem cells through the ATF4/PSAT1/Akt/GSK3β/β-catenin axis

Journal of Translational Medicine, 2023
Background Periodontal ligament stem cells (PDLSCs) are important seed cells for tissue engineering to realize the regeneration of alveolar bone. Understanding the gene regulatory mechanisms of osteogenic lineage differentiation in PDLSCs will facilitate
Linglu Jia, Dongfang Li, Ya-Nan Wang, Dongjiao Zhang, Xin Xu   +4 more
doaj   +3 more sources

Overexpression of the PSAT1 Gene in Nasopharyngeal Carcinoma Is an Indicator of Poor Prognosis [PDF]

Journal of Cancer, 2016
Nasopharyngeal carcinoma (NPC) is a common cancer in southern China and Southeast Asia, but risk stratification and treatment outcome in NPC patients remain suboptimal. Our study identified and validated metabolic drivers that are relevant to the pathogenesis of NPC using a published transcriptome.
Liao, Kuang-Ming, Chao, Tung-Bo, Tian, Yu-Feng, Lin, Ching-Yih, Lee, Sung-Wei, Chuang, Hua-Ying, Chan, Ti-Chun, Chen, Tzu-Ju, Hsing, Chung-Hsi, Sheu, Ming-Jen, Li, Chien-Feng   +10 more
openaire   +4 more sources

Overexpression of Phosphoserine Aminotransferase 1 (PSAT1) Predicts Poor Prognosis and Associates with Tumor Progression in Human Esophageal Squamous Cell Carcinoma

Cellular Physiology and Biochemistry, 2016
Background/Aims: Phosphoserine aminotransferase 1 (PSAT1) is over-expressed in many carcinoma tissues, however little is known regarding its expression and function in esophageal carcinogenesis.
Bingyan Liu, Yiping Jia, Yan Cao, Shaoqiu Wu, Haosheng Jiang, Xianjun Sun, Jun Ma, Xiang Yin, Aiwu Mao, Mingyi Shang   +9 more
doaj   +2 more sources

Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma [PDF]

Autophagy, 2019
GBM (glioblastoma multiforme) is the most common and aggressive brain tumor with no curative options available. Therefore, it is imperative to develop novel potent therapeutic drugs for GBM treatment. Here, we show that regorafenib, an oral multi-kinase inhibitor, exhibits superior therapeutic efficacy over temozolomide, the first-line chemotherapeutic
Jingwen Jiang, Lu Zhang, Haining Chen, Yunlong Lei, Tao Zhang, Yuelong Wang, Ping Jin, Jiang Lan, Li Zhou, Zhao Huang, Bowen Li, Yuan Liu, Wei Gao, Ke Xie, Liangxue Zhou, Edouard C. Nice, Yong Peng, Yihai Cao, Yuquan Wei, Kui Wang, Canhua Huang   +20 more
openaire   +3 more sources

PSAT1 inhibits mTORC1 activation by preventing Rag heterodimer formation in lung adenocarcinoma. [PDF]

Autophagy
The mechanistic target of rapamycin complex 1 (mTORC1) integrates environmental cues, especially amino acids, to regulate metabolism and ultimately cancer progression. Phosphoserine aminotransferase 1 (PSAT1) is a key enzyme in de novo serine synthesis and its overexpression has been reported to promote oncogenesis in various cancers.
Liu Y, Cheng Z, Zhang J, Zhang Y, Zhao T, Sun L, Wen G, Han T, Wang J.   +8 more
europepmc   +4 more sources

Investigation of phosphoserine aminotransferase 1(PSAT1) in breast cancer progression. [PDF]

, 2020
This dissertation describes my research into the involvement of phosphoserine aminotransferase 1 (PSAT1) in breast cancer progression; specifically, in triple negative breast cancer (TNBC) metastasis and endocrine resistance in estrogen receptor positive
Metcalf, Stephanie
openaire   +3 more sources