ATF4 Responds to Metabolic Stress in Drosophila
Frontiers in Bioscience-Landmark, 2023 Background: Activating transcription factor 4 (ATF4) is a fundamental basic-leucine zipper transcription factor that plays a pivotal role in numerous stress responses, including endoplasmic reticulum (ER) stress and the integrated stress response.
Soonhyuck Ok +5 more
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miRNA-1283 Regulates the PERK/ATF4 Pathway in Vascular Injury by Targeting ATF4. [PDF]
PLoS ONE, 2016 In our previous study, we found significant differences in the mRNA and microRNA (miRNA) levels among hypertensive patients with different degrees of vascular endothelial cells damage.
Ling He +5 more
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ATF4 Contributes to Ovulation via Regulating COX2/PGE2 Expression: A Potential Role of ATF4 in PCOS [PDF]
Frontiers in Endocrinology, 2018 Ovulatory disorder is common in patients with hyperprolactinemia or polycystic ovary syndrome (PCOS). Previous studies have shown that ATF4 plays critical role in apoptosis and glucose homeostasis, but its role in regulating reproductive function was not
Fangfang Di +16 more
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PRMT5 regulates ATF4 transcript splicing and oxidative stress response
Redox Biology, 2022 Protein methyltransferase 5 (PRMT5) symmetrically dimethylates arginine residues leading to regulation of transcription and splicing programs. Although PRMT5 has emerged as an attractive oncology target, the molecular determinants of PRMT5 dependency in ...
Samir H Barghout +2 more
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Integrative single-cell and bulk analyses reveal ATF4-associated immune suppression and WNT/β-catenin signaling in osteosarcoma [PDF]
Biology DirectBackground Osteosarcoma (OS) is highly heterogeneous and often exhibits an immunosuppressive tumor microenvironment, contributing to poor outcomes. The cell-type-resolved role of the ATF/CREB stress-response network, particularly ATF4, remains unclear in
Xiaomin Ding +3 more
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Role of Activating Transcription Factor 4 in Metabolic, Neurologic, and Ocular Diseases [PDF]
CellsCells respond to metabolic and environmental challenges through the integrated stress response (ISR), a cellular process that maintains homeostasis under diverse stressors.
Minwoo Kwon +5 more
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Up-Regulated ATF4 Expression Increases Cell Sensitivity to Apoptosis in Response to Radiation
Cellular Physiology and Biochemistry, 2017 Background/Aims: Activating transcription factor 4 (ATF4) is a member of the activating transcription factor family which regulates the expression of genes involved in amino acid metabolism, redox homeostasis and ER stress responses.
Ying Zong +4 more
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A bioinformatic analysis found low expression and clinical significance of ATF4 in breast cancer
HeliyonBackground: Activating Transcription Factor 4 (ATF4) expression exhibits differential patterns across different types of tumors. Besides, the pathogenesis of breast cancer is complex, and the exact relationship between ATF4 and ATF4 remains uncertain ...
Lujing Shao +4 more
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Cardioprotective effect of Ginger in a rat model of myocardial damage and its possible intervention in PERK-ATF4-CHOP-PUMA apoptotic pathway [PDF]
The Ukrainian Biochemical Journal, 2023 For today the exact mechanisms of myocardial infarction and ischemia/reperfusion injury are still not fully understood. ER stress and integrated stress response pathways are thought to play an essential role in myocardial damage. This includes activation
M. M. Mohammed +3 more
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Disease Models & Mechanisms, 2022 Metazoans have evolved various quality control mechanisms to cope with cellular stress inflicted by external and physiological conditions. ATF4 is a major effector of the integrated stress response, an evolutionarily conserved pathway that mediates ...
Deepika Vasudevan +4 more
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