ATF4 Responds to Metabolic Stress in Drosophila
Frontiers in Bioscience-Landmark, 2023 Background: Activating transcription factor 4 (ATF4) is a fundamental basic-leucine zipper transcription factor that plays a pivotal role in numerous stress responses, including endoplasmic reticulum (ER) stress and the integrated stress response.
Soonhyuck Ok +5 more
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The stress-induced transcription factor ATF4 has multiple conserved retrocopies that can alter gene expression [PDF]
HGG AdvancesSummary: The cell must defend against various stressors from internal and external sources that disrupt cell homeostasis. The integrated stress response (ISR) is a highly conserved pathway that helps restore this homeostasis through upregulating the ...
Hans M. Dalton +6 more
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PRMT5 regulates ATF4 transcript splicing and oxidative stress response
Redox Biology, 2022 Protein methyltransferase 5 (PRMT5) symmetrically dimethylates arginine residues leading to regulation of transcription and splicing programs. Although PRMT5 has emerged as an attractive oncology target, the molecular determinants of PRMT5 dependency in ...
Samir H Barghout +2 more
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Integrative single-cell and bulk analyses reveal ATF4-associated immune suppression and WNT/β-catenin signaling in osteosarcoma [PDF]
Biology DirectBackground Osteosarcoma (OS) is highly heterogeneous and often exhibits an immunosuppressive tumor microenvironment, contributing to poor outcomes. The cell-type-resolved role of the ATF/CREB stress-response network, particularly ATF4, remains unclear in
Xiaomin Ding +3 more
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Cardioprotective effect of Ginger in a rat model of myocardial damage and its possible intervention in PERK-ATF4-CHOP-PUMA apoptotic pathway [PDF]
The Ukrainian Biochemical Journal, 2023 For today the exact mechanisms of myocardial infarction and ischemia/reperfusion injury are still not fully understood. ER stress and integrated stress response pathways are thought to play an essential role in myocardial damage. This includes activation
M. M. Mohammed +3 more
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Disease Models & Mechanisms, 2022 Metazoans have evolved various quality control mechanisms to cope with cellular stress inflicted by external and physiological conditions. ATF4 is a major effector of the integrated stress response, an evolutionarily conserved pathway that mediates ...
Deepika Vasudevan +4 more
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Renal Failure, 2021 Aim Podocyte injury plays an important role in diabetic nephropathy (DN), yet the underlying molecular mechanisms of podocyte injury in DN is not clear.
Shizhu Yuan +5 more
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GCN2 upregulates autophagy in response to short-term deprivation of a single essential amino acid
Autophagy Reports, 2022 The ability to adapt the proteolysis rates based on fluctuations in essential amino acid (EAA) availability is essential for life. The GCN2-eIF2α-ATF4 signaling pathway is involved in the adaptive response to EAA deprivations.
Anne-Catherine Maurin +14 more
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Promoter methylation and expression pattern of DLX3, ATF4, and FRA1 genes during osteoblastic differentiation of adipose-derived mesenchymal stem cells [PDF]
BioImpacts, 2020 Introduction: Nowadays, mesenchymal stem cells are touted as suitable cell supply for the restoration of injured bone tissue. The existence of osteogenic differentiation makes these cells capable of replenishing damaged cells in the least possible time ...
Sevda Rahimzadeh +9 more
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Endocrine Regulations, 2023 Objective. Serine synthesis as well as endoplasmic reticulum stress and hypoxia are important factors of malignant tumor growth including glioblastoma.
Sliusar Myroslava Y. +8 more
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