Results 1 to 10 of about 30,346 (252)

ATF4 in cellular stress, ferroptosis, and cancer

Archives of Toxicology
Activating transcription factor 4 (ATF4), a member of the ATF/cAMP response element-binding (CREB) family, plays a critical role as a stress-induced transcription factor. It orchestrates cellular responses, particularly in the management of endoplasmic reticulum stress, amino acid deprivation, and oxidative challenges.
Hu Tang, Rui Kang, Jiao Liu
exaly   +3 more sources

ATF4 regulates CCL2 expression to promote endometrial cancer growth by controlling macrophage infiltration

Experimental Cell Research, 2017
Pingping Chen, Hong Zhu
exaly  

Ribosomal protein RPL41 induces rapid degradation of ATF4, a transcription factor critical for tumour cell survival in stress

Journal of Pathology, 2011
Aiyuan Wang, Sheng Xiao
exaly  

ATF4 Protein Deficiency Protects against High Fructose-induced Hypertriglyceridemia in Mice

Journal of Biological Chemistry, 2013
Guozhi Xiao, Shibing Yu, Sojin Lee
exaly  

Liver-specific Gene Inactivation of the Transcription Factor ATF4 Alleviates Alcoholic Liver Steatosis in Mice

Journal of Biological Chemistry, 2016
Yuzhong Xiao, Junjie Yu, Tingting Xia
exaly  

Transforming Growth Factor β Suppresses Osteoblast Differentiation via the Vimentin Activating Transcription Factor 4 (ATF4) Axis

Journal of Biological Chemistry, 2012
Tonghui Lin, Jeffry S Nyman, Florent Elefteriou   +2 more
exaly  

Functional validation of ATF4 and GADD34 in Neuro2a cells by CRISPR/Cas9-mediated genome editing

Molecular and Cellular Biochemistry, 2017
Kentaro Oh-Hashi, Naoki Sugiura, Fumimasa Amaya   +2 more
exaly  

Oxidized Phospholipids Regulate Expression of ATF4 and VEGF in Endothelial Cells via NRF2-Dependent Mechanism: Novel Point of Convergence Between Electrophilic and Unfolded Protein Stress Pathways

Arteriosclerosis, Thrombosis, and Vascular Biology, 2010
Taras Afonyushkin, Olga V Oskolkova, Valery N Bochkov   +2 more
exaly  

Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4

Immunity
exaly  

ATF4 Responds to Metabolic Stress in Drosophila

Frontiers in Bioscience-Landmark, 2023
Background: Activating transcription factor 4 (ATF4) is a fundamental basic-leucine zipper transcription factor that plays a pivotal role in numerous stress responses, including endoplasmic reticulum (ER) stress and the integrated stress response.
Soonhyuck Ok, Jung-Eun Park, Seunghee Byun, Kwonyoon Kang, Jaekyoung Son, Min-Ji Kang   +5 more
doaj   +4 more sources