Results 11 to 20 of about 32,812 (263)

miRNA-1283 Regulates the PERK/ATF4 Pathway in Vascular Injury by Targeting ATF4. [PDF]

PLoS ONE, 2016
In our previous study, we found significant differences in the mRNA and microRNA (miRNA) levels among hypertensive patients with different degrees of vascular endothelial cells damage.
Ling He, Jing Yuan, Qingyun Xu, Ruixue Chen, Liguo Chen, Meixia Fang   +5 more
doaj   +5 more sources

ATF4 Contributes to Ovulation via Regulating COX2/PGE2 Expression: A Potential Role of ATF4 in PCOS [PDF]

Frontiers in Endocrinology, 2018
Ovulatory disorder is common in patients with hyperprolactinemia or polycystic ovary syndrome (PCOS). Previous studies have shown that ATF4 plays critical role in apoptosis and glucose homeostasis, but its role in regulating reproductive function was not
Fangfang Di, Fangfang Di, Jiansheng Liu, Jiansheng Liu, Shang Li, Shang Li, Guangxin Yao, Guangxin Yao, Yan Hong, Yan Hong, Zi-Jiang Chen, Zi-Jiang Chen, Zi-Jiang Chen, Weiping Li, Weiping Li, Yanzhi Du, Yanzhi Du   +16 more
doaj   +4 more sources

Translation termination efficiency modulates ATF4 response by regulating ATF4 mRNA translation at 5′ short ORFs [PDF]

Nucleic Acids Research, 2012
The activating transcription factor 4 (ATF4) promotes transcriptional upregulation of specific target genes in response to cellular stress. ATF4 expression is regulated at the translational level by two short open reading frames (uORFs) in its 5'-untranslated region (5'-UTR).
Ait Ghezala, Hayet, Jolles, Béatrice, Salhi, Samia, Castrillo, Katia, Carpentier, Wassila, Cagnard, Nicolas, Bruhat, Alain, Fafournoux, Pierre, Jean-Jean, Olivier   +8 more
openaire   +6 more sources

Neurodegeneration: Keeping ATF4 on a Tight Leash [PDF]

Frontiers in Cellular Neuroscience, 2017
Activation of the endoplasmic reticulum (ER) stress and ER stress response, also known as the unfolded protein response (UPR), is common to various degenerative disorders. Therefore, signaling components of the UPR are currently emerging as potential targets for intervention and treatment of human diseases.
Priyamvada M. Pitale, Oleg Gorbatyuk, Oleg Gorbatyuk, Marina Gorbatyuk   +3 more
openaire   +4 more sources

Regulation of autophagy by ATF4 in response to severe hypoxia [PDF]

Oncogene, 2010
Activating transcription factor 4 (ATF4) is a transcription factor induced under severe hypoxia and a component of the PERK pathway involved in the unfolded protein response (UPR), a process that protects cells from the negative consequences of endoplasmic reticulum (ER) stress.
Rzymski, T., Milani, M., Pike, L., Buffa, F., Mellor, H. R., Winchester, L., Pires, I., Hammond, E., Ragoussis, I., Harris, A. L.   +9 more
core   +7 more sources

Up-Regulated ATF4 Expression Increases Cell Sensitivity to Apoptosis in Response to Radiation

Cellular Physiology and Biochemistry, 2017
Background/Aims: Activating transcription factor 4 (ATF4) is a member of the activating transcription factor family which regulates the expression of genes involved in amino acid metabolism, redox homeostasis and ER stress responses.
Ying Zong, Shijie Feng, Jinwei Cheng, Chenlin Yu, Guocai Lu   +4 more
doaj   +2 more sources

A bioinformatic analysis found low expression and clinical significance of ATF4 in breast cancer

Heliyon
Background: Activating Transcription Factor 4 (ATF4) expression exhibits differential patterns across different types of tumors. Besides, the pathogenesis of breast cancer is complex, and the exact relationship between ATF4 and ATF4 remains uncertain ...
Lujing Shao, Zhounan Zhu, Xinyan Jia, Yabin Ma, Chunyan Dong   +4 more
doaj   +2 more sources

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple-Negative Breast Cancer. [PDF]

Adv Sci (Weinh)
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Lai ZH, Wang Y, Li NN, Zeng L, Liu R, Li X, Li C, Ma XY, Fu W, Tang Y, Chen J, Liao N, Luo ML.   +12 more
europepmc   +2 more sources

JDP2 is directly regulated by ATF4 and modulates TRAIL sensitivity by suppressing the ATF4–DR5 axis [PDF]

FEBS Open Bio, 2020
Jun dimerization protein 2 (JDP2) is a bZip‐type transcription factor, which acts as a repressor or activator of several cellular processes, including cell differentiation and chromatin remodeling. Previously, we found that a stress‐responsive transcription factor, known as activating transcription factor 4 (ATF4), enhances JDP2 gene expression in ...
Máté János Engler, Junsei Mimura, Shun Yamazaki, Ken Itoh   +3 more
openaire   +2 more sources

Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin-ATF4 Axis. [PDF]

Adv Sci (Weinh)
Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Chae SA, Riddle RC, Jiang Z, Shin C, Du M, Son JS.   +5 more
europepmc   +2 more sources