Results 11 to 20 of about 31,889 (263)
Targeting the ATF4 pathway in cancer therapy.
Expert Opinion on Therapeutic Targets, 2012 INTRODUCTION: Activating transcription factor 4 (ATF4) is a member of the activating transcription factor family. ATF4 expression is increased in response to a diverse array of microenvironmental stresses including amino acid depletion, oxidative stress ...
Singleton, DC +3 more
core +3 more sources
Translation termination efficiency modulates ATF4 response by regulating ATF4 mRNA translation at 5' short ORFs [PDF]
Nucleic Acids Research, 2012 International audienceThe activating transcription factor 4 (ATF4) promotes transcriptional upregulation of specific target genes in response to cellular stress.
Fafournoux, Pierre +9 more
core +6 more sources
Neurodegeneration: Keeping ATF4 on a Tight Leash [PDF]
Frontiers in Cellular Neuroscience, 2017 Activation of the endoplasmic reticulum (ER) stress and ER stress response, also known as the unfolded protein response (UPR), is common to various degenerative disorders.
Priyamvada M. Pitale +2 more
core +4 more sources
Regulation of autophagy by ATF4 in response to severe hypoxia. [PDF]
Oncogene, 2010 Activating transcription factor 4 (ATF4) is a transcription factor induced under severe hypoxia and a component of the PERK pathway involved in the unfolded protein response (UPR), a process that protects cells from the negative consequences of ...
Rzymski, T;Milani, M;Pike, L;Buffa, F;Mellor, HR;Winchester, L;Pires, I;Hammond, E;Ragoussis, I;Harris, AL
core +7 more sources
JDP2 is directly regulated by ATF4 and modulates TRAIL sensitivity by suppressing the ATF4–DR5 axis [PDF]
FEBS Open Bio, 2020 Jun dimerization protein 2 (JDP2) is a bZip‐type transcription factor, which acts as a repressor or activator of several cellular processes, including cell differentiation and chromatin remodeling. Previously, we found that a stress‐responsive transcription factor, known as activating transcription factor 4 (ATF4), enhances JDP2 gene expression in ...
Máté János Engler +3 more
openaire +2 more sources
Renal Failure, 2021 Aim Podocyte injury plays an important role in diabetic nephropathy (DN), yet the underlying molecular mechanisms of podocyte injury in DN is not clear.
Shizhu Yuan +5 more
doaj +1 more source
GCN2 upregulates autophagy in response to short-term deprivation of a single essential amino acid
Autophagy Reports, 2022 The ability to adapt the proteolysis rates based on fluctuations in essential amino acid (EAA) availability is essential for life. The GCN2-eIF2α-ATF4 signaling pathway is involved in the adaptive response to EAA deprivations.
Anne-Catherine Maurin +14 more
doaj +1 more source
Developmental Cell, 2003 Multiple intracellular stress pathways converge on a single event--phosphorylation of the translation initiation factor eIF2alpha and subsequent translational activation of the transcription factor ATF4. Exploring the consequences of this event has highlighted the ways in which stress is sensed and responded to via many distinct pathways.
Rutkowski, D.Thomas, Kaufman, Randal J
openaire +2 more sources
Promoter methylation and expression pattern of DLX3, ATF4, and FRA1 genes during osteoblastic differentiation of adipose-derived mesenchymal stem cells [PDF]
BioImpacts, 2020 Introduction: Nowadays, mesenchymal stem cells are touted as suitable cell supply for the restoration of injured bone tissue. The existence of osteogenic differentiation makes these cells capable of replenishing damaged cells in the least possible time ...
Sevda Rahimzadeh +9 more
doaj +1 more source
Endocrine Regulations, 2023 Objective. Serine synthesis as well as endoplasmic reticulum stress and hypoxia are important factors of malignant tumor growth including glioblastoma.
Sliusar Myroslava Y. +8 more
doaj +1 more source