miRNA-1283 Regulates the PERK/ATF4 Pathway in Vascular Injury by Targeting ATF4. [PDF]
PLoS ONE, 2016 In our previous study, we found significant differences in the mRNA and microRNA (miRNA) levels among hypertensive patients with different degrees of vascular endothelial cells damage.
Ling He +5 more
doaj +5 more sources
ATF4 Contributes to Ovulation via Regulating COX2/PGE2 Expression: A Potential Role of ATF4 in PCOS [PDF]
Frontiers in Endocrinology, 2018 Ovulatory disorder is common in patients with hyperprolactinemia or polycystic ovary syndrome (PCOS). Previous studies have shown that ATF4 plays critical role in apoptosis and glucose homeostasis, but its role in regulating reproductive function was not
Fangfang Di +16 more
doaj +4 more sources
Neurodegeneration: Keeping ATF4 on a Tight Leash [PDF]
Frontiers in Cellular Neuroscience, 2017 Activation of the endoplasmic reticulum (ER) stress and ER stress response, also known as the unfolded protein response (UPR), is common to various degenerative disorders. Therefore, signaling components of the UPR are currently emerging as potential targets for intervention and treatment of human diseases.
Priyamvada M. Pitale +3 more
openaire +4 more sources
Translation termination efficiency modulates ATF4 response by regulating ATF4 mRNA translation at 5′ short ORFs [PDF]
Nucleic Acids Research, 2012 The activating transcription factor 4 (ATF4) promotes transcriptional upregulation of specific target genes in response to cellular stress. ATF4 expression is regulated at the translational level by two short open reading frames (uORFs) in its 5'-untranslated region (5'-UTR).
Ait Ghezala, Hayet +8 more
openaire +6 more sources
Regulation of autophagy by ATF4 in response to severe hypoxia [PDF]
Oncogene, 2010 Activating transcription factor 4 (ATF4) is a transcription factor induced under severe hypoxia and a component of the PERK pathway involved in the unfolded protein response (UPR), a process that protects cells from the negative consequences of endoplasmic reticulum (ER) stress.
Rzymski, T. +9 more
core +7 more sources
Frontiers in Oncology, 2021 BackgroundThe role of activating transcription factor 4 (ATF4) underlying gastric cancer (GC) remains unclear. The purpose of this study was to investigate the expression levels and biological functions of ATF4 in GC.MethodsExpression of ATF4 was ...
Mingliang Wang, Yida Lu, Youliang Wu
exaly +3 more sources
Role of Activating Transcription Factor 4 in Metabolic, Neurologic, and Ocular Diseases [PDF]
CellsCells respond to metabolic and environmental challenges through the integrated stress response (ISR), a cellular process that maintains homeostasis under diverse stressors.
Minwoo Kwon +5 more
doaj +2 more sources
PRMT5 regulates ATF4 transcript splicing and oxidative stress response
Redox Biology, 2022 Protein methyltransferase 5 (PRMT5) symmetrically dimethylates arginine residues leading to regulation of transcription and splicing programs. Although PRMT5 has emerged as an attractive oncology target, the molecular determinants of PRMT5 dependency in ...
Magdalena M Szewczyk +2 more
exaly +3 more sources
Brain-Derived Neurotrophic Factor Elevates Activating Transcription Factor 4 (ATF4) in Neurons and Promotes ATF4-Dependent Induction of Sesn2 [PDF]
Frontiers in Molecular Neuroscience, 2018 Activating transcription factor 4 (ATF4) plays important physiologic roles in the brain including regulation of learning and memory as well as neuronal survival and death. Yet, outside of translational regulation by the eIF2α-dependent stress response pathway, there is little information about how its levels are controlled in neurons.
Jin Liu +7 more
openaire +4 more sources
Up-Regulated ATF4 Expression Increases Cell Sensitivity to Apoptosis in Response to Radiation
Cellular Physiology and Biochemistry, 2017 Background/Aims: Activating transcription factor 4 (ATF4) is a member of the activating transcription factor family which regulates the expression of genes involved in amino acid metabolism, redox homeostasis and ER stress responses.
Ying Zong +4 more
doaj +2 more sources