Results 1 to 10 of about 10,043,563 (299)
The integrated stress response in budding yeast lifespan extension [PDF]
Microbial Cell, 2017 Aging is a complex, multi-factorial biological process shared by all living organisms. It is manifested by a gradual accumulation of molecular alterations that lead to the decline of normal physiological functions in a time-dependent fashion.
Spike D.L. Postnikoff +2 more
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The integrated stress response in pulmonary disease [PDF]
European Respiratory Review, 2020 The respiratory tract and its resident immune cells face daily exposure to stress, both from without and from within. Inhaled pathogens, including severe acute respiratory syndrome coronavirus 2, and toxins from pollution trigger a cellular defence ...
Giulia Emanuelli +3 more
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Targeting the Integrated Stress Response in Cancer Therapy [PDF]
Frontiers in Pharmacology, 2021 The integrated stress response (ISR) is an evolutionarily conserved intra-cellular signaling network which is activated in response to intrinsic and extrinsic stresses.
Xiaobing Tian +22 more
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Targeting the integrated stress response in hematologic malignancies
Experimental Hematology & Oncology, 2022 While numerous targeted therapies have been recently adopted to improve the treatment of hematologic malignancies, acquired or intrinsic resistance poses a significant obstacle to their efficacy.
Gus O. Nwosu +2 more
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Biomedicines, 2021 Cancer cells have the metabolic flexibility to adapt to heterogeneous tumor microenvironments. The integrated stress response (ISR) regulates the cellular adaptation response during nutrient stress.
Mei-Chun Chen +7 more
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A stay of execution: ATF4 regulation and potential outcomes for the integrated stress response
Frontiers in Molecular Neuroscience, 2023 ATF4 is a cellular stress induced bZIP transcription factor that is a hallmark effector of the integrated stress response. The integrated stress response is triggered by phosphorylation of the alpha subunit of the eukaryotic initiation factor 2 complex ...
Graham Neill, Glenn R. Masson
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CCR7 as a novel therapeutic target in t-cell PROLYMPHOCYTIC leukemia
Biomarker Research, 2020 T-cell prolymphocytic leukemia (T-PLL) is a poor prognostic disease with very limited options of efficient therapies. Most patients are refractory to chemotherapies and despite high response rates after alemtuzumab, virtually all patients relapse ...
Carlos Cuesta-Mateos +25 more
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Bisphenol A promotes stress granule assembly and modulates the integrated stress response
Biology Open, 2021 Bisphenol-A (BPA) is a ubiquitous precursor of polycarbonate plastics that is found in the blood and serum of >92% of Americans. While BPA has been well documented to act as a weak estrogen receptor (ER) agonist, its effects on cellular stress are ...
Marta M. Fay +17 more
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Frontiers in Immunology, 2023 IntroductionProteasome inhibition is first line therapy in multiple myeloma (MM). The immunological potential of cell death triggered by defects of the ubiquitin-proteasome system (UPS) and subsequent perturbations of protein homeostasis is, however ...
Zeinab Waad Sadiq +8 more
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Transcriptional Control of Metastasis by Integrated Stress Response Signaling
Frontiers in Oncology, 2021 As a central cellular program to sense and transduce stress signals, the integrated stress response (ISR) pathway has been implicated in cancer initiation and progression. Depending on the genetic mutation landscape, cellular context, and differentiation
Si Lu +10 more
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