Results 1 to 10 of about 485,665 (215)

Integrated Stress Response (ISR) Modulators in Vascular Diseases [PDF]

Cells
Vascular dysfunction lies at the core of cardiovascular diseases—the leading cause of global morbidity and mortality. Despite their prevalence, therapeutic options remain limited, in part due to an incomplete understanding of the molecular mechanisms ...
Alexander Kalinin, Ekaterina Zubkova, Irina Beloglazova, Yelena Parfyonova, Mikhail Menshikov   +4 more
doaj   +2 more sources

T cell-intrinsic integrated stress response: friend, foe, or frill? [PDF]

Journal of the National Cancer Center
Si Lu, Chenghang Zhao, Yuxiong Feng
doaj   +2 more sources

The emerging role and therapeutic implications of bacterial and parasitic deubiquitinating enzymes

Frontiers in Immunology, 2023
Deubiquitinating enzymes (DUBs) are emerging as key factors for the infection of human cells by pathogens such as bacteria and parasites. In this review, we discuss the most recent studies on the role of deubiquitinase activity in exploiting and ...
Markus Wehrmann, Markus Wehrmann, David Vilchez, David Vilchez, David Vilchez, David Vilchez   +5 more
doaj   +1 more source

Advanced Pathogenetic Concepts in T-Cell Prolymphocytic Leukemia and Their Translational Impact

Frontiers in Oncology, 2021
T-cell prolymphocytic leukemia (T-PLL) is the most common mature T-cell leukemia. It is a typically aggressively growing and chemotherapy-resistant malignancy with a poor prognosis.
Till Braun, Annika Dechow, Gregor Friedrich, Michael Seifert, Johanna Stachelscheid, Marco Herling, Marco Herling   +6 more
doaj   +1 more source

Cigarette Smoke Extract Activates Hypoxia-Inducible Factors in a Reactive Oxygen Species-Dependent Manner in Stroma Cells from Human Endometrium

Antioxidants, 2021
Cigarette smoking (CS) is a major contributing factor in the development of a large number of fatal and debilitating disorders, including degenerative diseases and cancers.
Naoko Kida, Yoshiyuki Matsuo, Yoshiko Hashimoto, Kenichiro Nishi, Tomoko Tsuzuki-Nakao, Hidemasa Bono, Tetsuo Maruyama, Kiichi Hirota, Hidetaka Okada   +8 more
doaj   +1 more source

Research progress of integrated stress response in pathogenesis of Alzheimer's disease

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Integrated stress response (ISR) is a cellular adaptive response induced by stress, which is strictly regulated by multiple phosphokinases, phosphatases and other proteins to maintain protein homeostasis.
SUN Hui, JIN Hongfu, GUO Shenrui, FENG Yiyuan, YIN Yafu, WANG Hui, CHENG Weiwei   +6 more
doaj   +1 more source

Integrated stress response restricts macrophage necroptosis

Life Science Alliance, 2022
Stress inhibits necroptosis in a PERK-dependent manner via reduced RIPK1-RIPK3-MLKL signaling, showing an integral mechanistic connection between stress responses and programmed cell death.
David E Place, Parimal Samir, RK Subbarao Malireddi, Thirumala-Devi Kanneganti   +3 more
doaj   +1 more source

Inhibiting SARS-CoV-2 infection in vitro by suppressing its receptor, angiotensin-converting enzyme 2, via aryl-hydrocarbon receptor signal

Scientific Reports, 2021
Since understanding molecular mechanisms of SARS-CoV-2 infection is extremely important for developing effective therapies against COVID-19, we focused on the internalization mechanism of SARS-CoV-2 via ACE2.
Keiji Tanimoto, Kiichi Hirota, Takahiro Fukazawa, Yoshiyuki Matsuo, Toshihito Nomura, Nazmul Tanuza, Nobuyuki Hirohashi, Hidemasa Bono, Takemasa Sakaguchi   +8 more
doaj   +1 more source

Micro-RNA networks in T-cell prolymphocytic leukemia reflect T-cell activation and shape DNA damage response and survival pathways

Haematologica, 2020
T-cell prolymphocytic leukemia (T-PLL) is a poor-prognostic mature T-cell malignancy. It typically presents with exponentially rising lymphocyte counts, splenomegaly, and bone marrow infiltration.
Till Braun, Markus Glass, Linus Wahnschaffe, Moritz Otte, Petra Mayer, Marek Franitza, Janine Altmüller, Michael Hallek, Stefan Hüttelmaier, Alexandra Schrader, Marco Herling   +10 more
doaj   +1 more source

Signaling plasticity in the integrated stress response

Frontiers in Cell and Developmental Biology, 2023
The Integrated Stress Response (ISR) is an essential homeostatic signaling network that controls the cell’s biosynthetic capacity. Four ISR sensor kinases detect multiple stressors and relay this information to downstream effectors by phosphorylating a ...
Morgane Boone, Francesca Zappa
doaj   +1 more source