Results 1 to 10 of about 466,137 (253)

The integrated stress response in neurodegenerative diseases [PDF]

Molecular Neurodegeneration
The integrated stress response (ISR) is a conserved network in eukaryotic cells that mediates adaptive responses to diverse stressors. The ISR pathway ensures cell survival and homeostasis by regulating protein synthesis in response to internal or ...
Maria Astrid Bravo-Jimenez, Shivangi Sharma, Soheila Karimi-Abdolrezaee   +2 more
doaj   +5 more sources

Signaling plasticity in the integrated stress response

Frontiers in Cell and Developmental Biology, 2023
The Integrated Stress Response (ISR) is an essential homeostatic signaling network that controls the cell’s biosynthetic capacity. Four ISR sensor kinases detect multiple stressors and relay this information to downstream effectors by phosphorylating a ...
Morgane Boone, Francesca Zappa
doaj   +3 more sources

The integrated stress response in pulmonary disease [PDF]

European Respiratory Review, 2020
The respiratory tract and its resident immune cells face daily exposure to stress, both from without and from within. Inhaled pathogens, including severe acute respiratory syndrome coronavirus 2, and toxins from pollution trigger a cellular defence ...
Giulia Emanuelli, Nikou Nassehzadeh-Tabriz, Nick W. Morrell, Stefan J. Marciniak   +3 more
doaj   +3 more sources

Integrated stress response restricts macrophage necroptosis [PDF]

Life Science Alliance, 2022
Stress inhibits necroptosis in a PERK-dependent manner via reduced RIPK1-RIPK3-MLKL signaling, showing an integral mechanistic connection between stress responses and programmed cell death.
David E Place, Parimal Samir, RK Subbarao Malireddi, Thirumala-Devi Kanneganti   +3 more
doaj   +3 more sources

Targeting the Integrated Stress Response in Cancer Therapy [PDF]

Frontiers in Pharmacology, 2021
The integrated stress response (ISR) is an evolutionarily conserved intra-cellular signaling network which is activated in response to intrinsic and extrinsic stresses.
Xiaobing Tian, Xiaobing Tian, Xiaobing Tian, Xiaobing Tian, Shengliang Zhang, Shengliang Zhang, Shengliang Zhang, Shengliang Zhang, Lanlan Zhou, Lanlan Zhou, Lanlan Zhou, Lanlan Zhou, Attila A. Seyhan, Attila A. Seyhan, Attila A. Seyhan, Attila A. Seyhan, Liz Hernandez Borrero, Yiqun Zhang, Wafik S. El-Deiry, Wafik S. El-Deiry, Wafik S. El-Deiry, Wafik S. El-Deiry, Wafik S. El-Deiry   +22 more
doaj   +3 more sources

Integrated Stress Response (ISR) Modulators in Vascular Diseases [PDF]

Cells
Vascular dysfunction lies at the core of cardiovascular diseases—the leading cause of global morbidity and mortality. Despite their prevalence, therapeutic options remain limited, in part due to an incomplete understanding of the molecular mechanisms ...
Alexander Kalinin, Ekaterina Zubkova, Irina Beloglazova, Yelena Parfyonova, Mikhail Menshikov   +4 more
doaj   +2 more sources

Targeting the integrated stress response in hematologic malignancies

Experimental Hematology & Oncology, 2022
While numerous targeted therapies have been recently adopted to improve the treatment of hematologic malignancies, acquired or intrinsic resistance poses a significant obstacle to their efficacy.
Gus O. Nwosu, Jason A. Powell, Stuart M. Pitson   +2 more
doaj   +4 more sources

Termination of the integrated stress response. [PDF]

Science
Stress responses enable cells to detect, adapt to, and survive challenges. The benefit of these signaling pathways depends on their reversibility. The integrated stress response (ISR) is elicited by phosphorylation of eukaryotic translation initiation factor eIF2, which traps and inhibits rate-limiting translation factor eIF2B, thereby attenuating ...
De Miguel C, Thorkelsson SR, Fatalska A, Hodgson G, Dalglish M, Wang C, Bertolotti A.   +6 more
europepmc   +3 more sources

T cell-intrinsic integrated stress response: friend, foe, or frill? [PDF]

Journal of the National Cancer Center
Si Lu, Chenghang Zhao, Yuxiong Feng
doaj   +2 more sources

Targeting the integrated stress response in ophthalmology [PDF]

Current Eye Research, 2021
Purpose: To summarize the Integrated Stress Response (ISR) in the context of ophthalmology, with special interest on the cornea and anterior segment. Results: The ISR is a powerful and conserved signaling pathway that allows for cells to respond to a diverse array of both intracellular and extracellular stressors. The pathway is classically responsible
Hsiao-Sang Chu (548628), Cornelia Peterson (10015772), Albert Jun (10015775), James Foster (59241)   +3 more
openaire   +3 more sources