Results 31 to 40 of about 466,137 (253)

Eukaryotic response to hypothermia in relation to integrated stress responses

Cell Stress and Chaperones, 2020
Eukaryotic cells respond to hypothermic stress through a series of regulatory mechanisms that preserve energy resources and prolong cell survival. These mechanisms include alterations in gene expression, attenuated global protein synthesis and changes in the lipid composition of the phospholipid bilayer.
Naki A. Adjirackor, Katie E. Harvey, Simon C. Harvey   +2 more
openaire   +3 more sources

Signaling Overlap between the Golgi Stress Response and Cysteine Metabolism in Huntington’s Disease

Antioxidants, 2021
Huntington’s disease (HD) is caused by expansion of polyglutamine repeats in the protein huntingtin, which affects the corpus striatum of the brain. The polyglutamine repeats in mutant huntingtin cause its aggregation and elicit toxicity by affecting ...
Bindu D. Paul
doaj   +1 more source

Integration of O-GlcNAc into Stress Response Pathways

Cells, 2022
The modification of nuclear, mitochondrial, and cytosolic proteins by O-linked βN-acetylglucosamine (O-GlcNAc) has emerged as a dynamic and essential post-translational modification of mammalian proteins. O-GlcNAc is cycled on and off over 5000 proteins in response to diverse stimuli impacting protein function and, in turn, epigenetics and ...
Kamau M. M. Fahie, Kyriakos N. Papanicolaou, Natasha E. Zachara   +2 more
openaire   +3 more sources

Plasticity of the mammalian integrated stress response. [PDF]

Nature
An increased level of phosphorylation of eukaryotic translation initiation factor 2 subunit-α (eIF2α, encoded by EIF2S1; eIF2α-p) coupled with decreased guanine nucleotide exchange activity of eIF2B is a hallmark of the 'canonical' integrated stress response (c-ISR)1.
Chen CW, Papadopoli D, Szkop KJ, Guan BJ, Alzahrani M, Wu J, Jobava R, Asraf MM, Krokowski D, Vourekas A, Merrick WC, Komar AA, Koromilas AE, Gorospe M, Payea MJ, Wang F, Clayton BLL, Tesar PJ, Schaffer A, Miron A, Bederman I, Jankowsky E, Vogel C, Valášek LS, Dinman JD, Zhang Y, Tirosh B, Larsson O, Topisirovic I, Hatzoglou M.   +29 more
europepmc   +4 more sources

Integrated Endoplasmic Reticulum Stress Responses in Cancer [PDF]

Cancer Research, 2007
Abstract The endoplasmic reticulum (ER) has emerged as a major site of cellular homeostasis regulation, particularly in the unfolded protein response, which is being found to play a major role in cancer and many other diseases. Here, we address ER-mediated signaling and regulations in the context of environmental challenges in cancer ...
Michel, Moenner, Olivier, Pluquet, Marion, Bouchecareilh, Eric, Chevet   +3 more
openaire   +2 more sources

ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes

Cell Reports
Summary: The majority of severe early-onset and juvenile cases of amyotrophic lateral sclerosis (ALS) are caused by mutations in the FUS gene, resulting in rapid disease progression.
Hafiza Alirzayeva, Rute Loureiro, Seda Koyuncu, Franziska Hommen, Yara Nabawi, William Hongyu Zhang, Thien T.P. Dao, Markus Wehrmann, Hyun Ju Lee, David Vilchez   +9 more
doaj   +1 more source

EIF2α phosphorylation: a hallmark of both autophagy and immunogenic cell death

Molecular & Cellular Oncology, 2020
Different intrinsic and extrinsic stress pathways including endoplasmic reticulum (ER) stress converge on the phosphorylation of eukaryotic translation initiation factor 2A (EIF2A, best known as eIF2α), which characterizes the so-called “integrated ...
Juliette Humeau, Lucillia Bezu, Oliver Kepp, Guido Kroemer   +3 more
doaj   +1 more source

eIF2B-capturing viral protein NSs suppresses the integrated stress response

Nature Communications, 2021
Here the authors show that a viral protein interferes with the binding of phosphorylated eIF2 to eIF2B, thereby suppressing the host integrated stress response (ISR). This suppression of the ISR abrogates translational changes of the host and ameliorates
Kazuhiro Kashiwagi, Yuichi Shichino, Tatsuya Osaki, Ayako Sakamoto, Madoka Nishimoto, Mari Takahashi, Mari Mito, Friedemann Weber, Yoshiho Ikeuchi, Shintaro Iwasaki, Takuhiro Ito   +10 more
doaj   +1 more source

Contributions of Ccr4 and Gcn2 to the Translational Response of C. neoformans to Host-Relevant Stressors and Integrated Stress Response Induction

mBio, 2023
In response to the host environment, the human pathogen Cryptococcus neoformans must rapidly reprogram its translatome from one which promotes growth to one which is responsive to host stress.
Corey M. Knowles, David Goich, Amanda L. M. Bloom, Murat C. Kalem, John C. Panepinto   +4 more
doaj   +1 more source

Integrated metabolomics for abiotic stress responses in plants [PDF]

Current Opinion in Plant Biology, 2015
Plants are considered to biosynthesize specialized (traditionally called secondary) metabolites to adapt to environmental stresses such as biotic and abiotic stresses. The majority of specialized metabolites induced by abiotic stress characteristically exhibit antioxidative activity in vitro, but their function in vivo is largely yet to be ...
Ryo, Nakabayashi, Kazuki, Saito
openaire   +2 more sources