Results 11 to 20 of about 10,095,518 (284)

The integrated stress response in pulmonary disease [PDF]

European Respiratory Review, 2020
The respiratory tract and its resident immune cells face daily exposure to stress, both from without and from within. Inhaled pathogens, including severe acute respiratory syndrome coronavirus 2, and toxins from pollution trigger a cellular defence ...
Giulia Emanuelli, Nikou Nassehzadeh-Tabriz, Nick W. Morrell, Stefan J. Marciniak   +3 more
doaj   +6 more sources

The integrated stress response in budding yeast lifespan extension [PDF]

Microbial Cell, 2017
Aging is a complex, multi-factorial biological process shared by all living organisms. It is manifested by a gradual accumulation of molecular alterations that lead to the decline of normal physiological functions in a time-dependent fashion.
Spike D.L. Postnikoff, Jay E. Johnson, Jessica K. Tyler   +2 more
doaj   +2 more sources

Eukaryotic response to hypothermia in relation to integrated stress responses

Cell Stress and Chaperones, 2020
Eukaryotic cells respond to hypothermic stress through a series of regulatory mechanisms that preserve energy resources and prolong cell survival. These mechanisms include alterations in gene expression, attenuated global protein synthesis and changes in
Adjirackor, N. A., Harvey, S. C., Harvey, K. E.   +2 more
core   +4 more sources

The integrated stress response promotes B7H6 expression [PDF]

Journal of Molecular Medicine, 2020
International audienceThe B7 family member, B7H6, is a ligand for the natural killer cell receptor NKp30. B7H6 is hardly expressed on normal tissues, but undergoes upregulation on different types of tumors, implicating it as an attractive target for ...
Tai-Schmiedel, Julie, Mandelboim, Ofer, Bolsée, Jennifer, Gilham, David E, Seidel, Einat, Stern-Ginossar, Noam, Chevet, Eric, Springuel, Lorraine, Obiedat, Akram, Mahameed, Mohamed, Shmuel, Miriam, Avril, Tony, Charpak-Amikam, Yoav, Dipta, Priya, Tirosh, Boaz   +14 more
core   +4 more sources

Targeting the Integrated Stress Response in Cancer Therapy [PDF]

Frontiers in Pharmacology, 2021
The integrated stress response (ISR) is an evolutionarily conserved intra-cellular signaling network which is activated in response to intrinsic and extrinsic stresses.
Xiaobing Tian, Xiaobing Tian, Xiaobing Tian, Xiaobing Tian, Shengliang Zhang, Shengliang Zhang, Shengliang Zhang, Shengliang Zhang, Lanlan Zhou, Lanlan Zhou, Lanlan Zhou, Lanlan Zhou, Attila A. Seyhan, Attila A. Seyhan, Attila A. Seyhan, Attila A. Seyhan, Liz Hernandez Borrero, Yiqun Zhang, Wafik S. El-Deiry, Wafik S. El-Deiry, Wafik S. El-Deiry, Wafik S. El-Deiry, Wafik S. El-Deiry   +22 more
doaj   +3 more sources

The integrated stress response in neurodegenerative diseases

Molecular Neurodegeneration
The integrated stress response (ISR) is a conserved network in eukaryotic cells that mediates adaptive responses to diverse stressors. The ISR pathway ensures cell survival and homeostasis by regulating protein synthesis in response to internal or ...
Maria Astrid Bravo-Jimenez, Shivangi Sharma, Soheila Karimi-Abdolrezaee   +2 more
doaj   +4 more sources

Targeting the integrated stress response in hematologic malignancies

Experimental Hematology & Oncology, 2022
While numerous targeted therapies have been recently adopted to improve the treatment of hematologic malignancies, acquired or intrinsic resistance poses a significant obstacle to their efficacy.
Gus O. Nwosu, Jason A. Powell, Stuart M. Pitson   +2 more
doaj   +4 more sources

Termination of the integrated stress response. [PDF]

Science
Stress responses enable cells to detect, adapt to, and survive challenges. The benefit of these signaling pathways depends on their reversibility. The integrated stress response (ISR) is elicited by phosphorylation of eukaryotic translation initiation factor eIF2, which traps and inhibits rate-limiting translation factor eIF2B, thereby attenuating ...
De Miguel C, Thorkelsson SR, Fatalska A, Hodgson G, Dalglish M, Wang C, Bertolotti A.   +6 more
europepmc   +3 more sources

Plant molecular response to combined drought and nematode stress [PDF]

, 2011
Plants are adapted to respond to precise environmental stress conditions, activating specific molecular and physiological changes in order to minimise damage.
Atkinson, Nicola Jane
core   +6 more sources

Targeting the integrated stress response in ophthalmology [PDF]

Current Eye Research, 2021
Purpose: To summarize the Integrated Stress Response (ISR) in the context of ophthalmology, with special interest on the cornea and anterior segment. Results: The ISR is a powerful and conserved signaling pathway that allows for cells to respond to a diverse array of both intracellular and extracellular stressors. The pathway is classically responsible
Hsiao-Sang Chu (548628), Cornelia Peterson (10015772), Albert Jun (10015775), James Foster (59241)   +3 more
openaire   +3 more sources