Results 11 to 20 of about 10,043,563 (299)

The integrated stress response in lung disease. [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2014
Lungs are repeatedly exposed to inhaled toxic insults, such as smoke, diesel exhaust, and microbes, which elicit cellular stress responses. The phosphorylation of eukaryotic translation initiation factor 2α by one of four stress-sensing kinases triggers ...
Marciniak, S.J., Hiemstra, P.S., Wout, E.F.A. van 't   +2 more
core   +6 more sources

Signaling plasticity in the integrated stress response

Frontiers in Cell and Developmental Biology, 2023
The Integrated Stress Response (ISR) is an essential homeostatic signaling network that controls the cell’s biosynthetic capacity. Four ISR sensor kinases detect multiple stressors and relay this information to downstream effectors by phosphorylating a ...
Morgane Boone, Francesca Zappa
doaj   +3 more sources

Eukaryotic response to hypothermia in relation to integrated stress responses

Cell Stress and Chaperones, 2020
Eukaryotic cells respond to hypothermic stress through a series of regulatory mechanisms that preserve energy resources and prolong cell survival. These mechanisms include alterations in gene expression, attenuated global protein synthesis and changes in
Adjirackor, N. A., Harvey, S. C., Harvey, K. E., Adjirackor, Naki A., Harvey, Simon C., Harvey, Katie E.   +5 more
core   +4 more sources

The integrated stress response promotes B7H6 expression [PDF]

Journal of Molecular Medicine, 2020
International audienceThe B7 family member, B7H6, is a ligand for the natural killer cell receptor NKp30. B7H6 is hardly expressed on normal tissues, but undergoes upregulation on different types of tumors, implicating it as an attractive target for ...
Tai-Schmiedel, Julie, Mandelboim, Ofer, Bolsée, Jennifer, Gilham, David E, Seidel, Einat, Stern-Ginossar, Noam, Chevet, Eric, Springuel, Lorraine, Obiedat, Akram, Mahameed, Mohamed, Shmuel, Miriam, Avril, Tony, Charpak-Amikam, Yoav, Dipta, Priya, Tirosh, Boaz   +14 more
core   +4 more sources

Integrated stress response restricts macrophage necroptosis [PDF]

Life Science Alliance, 2022
Stress inhibits necroptosis in a PERK-dependent manner via reduced RIPK1-RIPK3-MLKL signaling, showing an integral mechanistic connection between stress responses and programmed cell death.
David E Place, Parimal Samir, RK Subbarao Malireddi, Thirumala-Devi Kanneganti   +3 more
doaj   +3 more sources

Integrated Stress Response (ISR) Modulators in Vascular Diseases [PDF]

Cells
Vascular dysfunction lies at the core of cardiovascular diseases—the leading cause of global morbidity and mortality. Despite their prevalence, therapeutic options remain limited, in part due to an incomplete understanding of the molecular mechanisms ...
Alexander Kalinin, Ekaterina Zubkova, Irina Beloglazova, Yelena Parfyonova, Mikhail Menshikov   +4 more
doaj   +2 more sources

The integrated stress response in neurodegenerative diseases

Molecular Neurodegeneration
The integrated stress response (ISR) is a conserved network in eukaryotic cells that mediates adaptive responses to diverse stressors. The ISR pathway ensures cell survival and homeostasis by regulating protein synthesis in response to internal or ...
Maria Astrid Bravo-Jimenez, Shivangi Sharma, Soheila Karimi-Abdolrezaee   +2 more
doaj   +4 more sources

Termination of the integrated stress response. [PDF]

Science
Stress responses enable cells to detect, adapt to, and survive challenges. The benefit of these signaling pathways depends on their reversibility. The integrated stress response (ISR) is elicited by phosphorylation of eukaryotic translation initiation factor eIF2, which traps and inhibits rate-limiting translation factor eIF2B, thereby attenuating ...
De Miguel C, Thorkelsson SR, Fatalska A, Hodgson G, Dalglish M, Wang C, Bertolotti A.   +6 more
europepmc   +3 more sources

T cell-intrinsic integrated stress response: friend, foe, or frill? [PDF]

Journal of the National Cancer Center
Si Lu, Chenghang Zhao, Yuxiong Feng
doaj   +2 more sources

The emerging role and therapeutic implications of bacterial and parasitic deubiquitinating enzymes

Frontiers in Immunology, 2023
Deubiquitinating enzymes (DUBs) are emerging as key factors for the infection of human cells by pathogens such as bacteria and parasites. In this review, we discuss the most recent studies on the role of deubiquitinase activity in exploiting and ...
Markus Wehrmann, Markus Wehrmann, David Vilchez, David Vilchez, David Vilchez, David Vilchez   +5 more
doaj   +1 more source