Results 11 to 20 of about 466,137 (253)

The emerging role and therapeutic implications of bacterial and parasitic deubiquitinating enzymes

Frontiers in Immunology, 2023
Deubiquitinating enzymes (DUBs) are emerging as key factors for the infection of human cells by pathogens such as bacteria and parasites. In this review, we discuss the most recent studies on the role of deubiquitinase activity in exploiting and ...
Markus Wehrmann, Markus Wehrmann, David Vilchez, David Vilchez, David Vilchez, David Vilchez   +5 more
doaj   +1 more source

Advanced Pathogenetic Concepts in T-Cell Prolymphocytic Leukemia and Their Translational Impact

Frontiers in Oncology, 2021
T-cell prolymphocytic leukemia (T-PLL) is the most common mature T-cell leukemia. It is a typically aggressively growing and chemotherapy-resistant malignancy with a poor prognosis.
Till Braun, Annika Dechow, Gregor Friedrich, Michael Seifert, Johanna Stachelscheid, Marco Herling, Marco Herling   +6 more
doaj   +1 more source

Cigarette Smoke Extract Activates Hypoxia-Inducible Factors in a Reactive Oxygen Species-Dependent Manner in Stroma Cells from Human Endometrium

Antioxidants, 2021
Cigarette smoking (CS) is a major contributing factor in the development of a large number of fatal and debilitating disorders, including degenerative diseases and cancers.
Naoko Kida, Yoshiyuki Matsuo, Yoshiko Hashimoto, Kenichiro Nishi, Tomoko Tsuzuki-Nakao, Hidemasa Bono, Tetsuo Maruyama, Kiichi Hirota, Hidetaka Okada   +8 more
doaj   +1 more source

Research progress of integrated stress response in pathogenesis of Alzheimer's disease

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Integrated stress response (ISR) is a cellular adaptive response induced by stress, which is strictly regulated by multiple phosphokinases, phosphatases and other proteins to maintain protein homeostasis.
SUN Hui, JIN Hongfu, GUO Shenrui, FENG Yiyuan, YIN Yafu, WANG Hui, CHENG Weiwei   +6 more
doaj   +1 more source

Autophagy and the Integrated Stress Response [PDF]

Molecular Cell, 2010
Autophagy is a tightly regulated pathway involving the lysosomal degradation of cytoplasmic organelles or cytosolic components. This pathway can be stimulated by multiple forms of cellular stress, including nutrient or growth factor deprivation, hypoxia, reactive oxygen species, DNA damage, protein aggregates, damaged organelles, or intracellular ...
Kroemer, Guido, Mariño, Guillermo, Levine, Beth   +2 more
openaire   +2 more sources

Integrated stress responses in Salmonella [PDF]

International Journal of Food Microbiology, 2012
The foodborne gram-negative pathogen Salmonella must adapt to varied environmental conditions encountered within foods, the host gastrointestinal tract and the phagosomes of host macrophages. Adaptation is achieved through the coordinate regulation of gene expression in response to environmental signals such as temperature, pH, osmolarity, redox state,
Shu, Shen, Ferric C, Fang
openaire   +2 more sources

Inhibiting SARS-CoV-2 infection in vitro by suppressing its receptor, angiotensin-converting enzyme 2, via aryl-hydrocarbon receptor signal

Scientific Reports, 2021
Since understanding molecular mechanisms of SARS-CoV-2 infection is extremely important for developing effective therapies against COVID-19, we focused on the internalization mechanism of SARS-CoV-2 via ACE2.
Keiji Tanimoto, Kiichi Hirota, Takahiro Fukazawa, Yoshiyuki Matsuo, Toshihito Nomura, Nazmul Tanuza, Nobuyuki Hirohashi, Hidemasa Bono, Takemasa Sakaguchi   +8 more
doaj   +1 more source

Micro-RNA networks in T-cell prolymphocytic leukemia reflect T-cell activation and shape DNA damage response and survival pathways

Haematologica, 2020
T-cell prolymphocytic leukemia (T-PLL) is a poor-prognostic mature T-cell malignancy. It typically presents with exponentially rising lymphocyte counts, splenomegaly, and bone marrow infiltration.
Till Braun, Markus Glass, Linus Wahnschaffe, Moritz Otte, Petra Mayer, Marek Franitza, Janine Altmüller, Michael Hallek, Stefan Hüttelmaier, Alexandra Schrader, Marco Herling   +10 more
doaj   +1 more source

Involvement of Integrated Stress Response in Drug-Induced Secondary Dystonia [PDF]

ACS Omega
Tricia A. Simon, Sanjana B. Parise, Natalie E. Jackson, Rekha C. Patel   +3 more
doaj   +2 more sources

The Integrated Stress Response in Lung Disease [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2014
Abstract Lungs are repeatedly exposed to inhaled toxic insults, such as smoke, diesel exhaust, and microbes, which elicit cellular stress responses. The phosphorylation of eukaryotic translation initiation factor 2α by one of four stress-sensing kinases triggers a pathway called the integrated stress response that helps protect ...
Wout, E.F.A. van 't, Hiemstra, P.S., Marciniak, S.J.   +2 more
openaire   +3 more sources