Results 21 to 30 of about 10,095,518 (284)
Autophagy and the Integrated Stress Response [PDF]
Molecular Cell, 2010 Autophagy is a tightly regulated pathway involving the lysosomal degradation of cytoplasmic organelles or cytosolic components. This pathway can be stimulated by multiple forms of cellular stress, including nutrient or growth factor deprivation, hypoxia, reactive oxygen species, DNA damage, protein aggregates, damaged organelles, or intracellular ...
Kroemer, Guido +2 more
openaire +2 more sources
Integrated stress responses in Salmonella [PDF]
International Journal of Food Microbiology, 2012 The foodborne gram-negative pathogen Salmonella must adapt to varied environmental conditions encountered within foods, the host gastrointestinal tract and the phagosomes of host macrophages. Adaptation is achieved through the coordinate regulation of gene expression in response to environmental signals such as temperature, pH, osmolarity, redox state,
Shu, Shen, Ferric C, Fang
openaire +2 more sources
Biomedicines, 2021 Cancer cells have the metabolic flexibility to adapt to heterogeneous tumor microenvironments. The integrated stress response (ISR) regulates the cellular adaptation response during nutrient stress.
Mei-Chun Chen +7 more
doaj +1 more source
A stay of execution: ATF4 regulation and potential outcomes for the integrated stress response
Frontiers in Molecular Neuroscience, 2023 ATF4 is a cellular stress induced bZIP transcription factor that is a hallmark effector of the integrated stress response. The integrated stress response is triggered by phosphorylation of the alpha subunit of the eukaryotic initiation factor 2 complex ...
Graham Neill, Glenn R. Masson
doaj +1 more source
CCR7 as a novel therapeutic target in t-cell PROLYMPHOCYTIC leukemia
Biomarker Research, 2020 T-cell prolymphocytic leukemia (T-PLL) is a poor prognostic disease with very limited options of efficient therapies. Most patients are refractory to chemotherapies and despite high response rates after alemtuzumab, virtually all patients relapse ...
Carlos Cuesta-Mateos +25 more
doaj +1 more source
Involvement of Integrated Stress Response in Drug-Induced Secondary Dystonia [PDF]
ACS OmegaTricia A. Simon +3 more
doaj +2 more sources
Architecture, Dynamics, and Function of the General Stress Response System in B. subtilis [PDF]
, 2012 Cells exhibit diverse and dynamic responses to stress. However, in many cases it remains unclear what the dynamics are, how they are generated, and why they are beneficial to the cell or organism. To investigate these issues we studied the General Stress
Young, Jonathan Wan
core +1 more source
Bisphenol A promotes stress granule assembly and modulates the integrated stress response
Biology Open, 2021 Bisphenol-A (BPA) is a ubiquitous precursor of polycarbonate plastics that is found in the blood and serum of >92% of Americans. While BPA has been well documented to act as a weak estrogen receptor (ER) agonist, its effects on cellular stress are ...
Marta M. Fay +17 more
doaj +1 more source
Frontiers in Immunology, 2023 IntroductionProteasome inhibition is first line therapy in multiple myeloma (MM). The immunological potential of cell death triggered by defects of the ubiquitin-proteasome system (UPS) and subsequent perturbations of protein homeostasis is, however ...
Zeinab Waad Sadiq +8 more
doaj +1 more source
Transcriptional Control of Metastasis by Integrated Stress Response Signaling
Frontiers in Oncology, 2021 As a central cellular program to sense and transduce stress signals, the integrated stress response (ISR) pathway has been implicated in cancer initiation and progression. Depending on the genetic mutation landscape, cellular context, and differentiation
Si Lu +10 more
doaj +1 more source