Results 21 to 30 of about 10,043,563 (299)

Advanced Pathogenetic Concepts in T-Cell Prolymphocytic Leukemia and Their Translational Impact

Frontiers in Oncology, 2021
T-cell prolymphocytic leukemia (T-PLL) is the most common mature T-cell leukemia. It is a typically aggressively growing and chemotherapy-resistant malignancy with a poor prognosis.
Till Braun, Annika Dechow, Gregor Friedrich, Michael Seifert, Johanna Stachelscheid, Marco Herling, Marco Herling   +6 more
doaj   +1 more source

Targeting the integrated stress response in ophthalmology [PDF]

Current Eye Research, 2021
Purpose: To summarize the Integrated Stress Response (ISR) in the context of ophthalmology, with special interest on the cornea and anterior segment. Results: The ISR is a powerful and conserved signaling pathway that allows for cells to respond to a diverse array of both intracellular and extracellular stressors. The pathway is classically responsible
Hsiao-Sang Chu (548628), Cornelia Peterson (10015772), Albert Jun (10015775), James Foster (59241)   +3 more
openaire   +3 more sources

Cigarette Smoke Extract Activates Hypoxia-Inducible Factors in a Reactive Oxygen Species-Dependent Manner in Stroma Cells from Human Endometrium

Antioxidants, 2021
Cigarette smoking (CS) is a major contributing factor in the development of a large number of fatal and debilitating disorders, including degenerative diseases and cancers.
Naoko Kida, Yoshiyuki Matsuo, Yoshiko Hashimoto, Kenichiro Nishi, Tomoko Tsuzuki-Nakao, Hidemasa Bono, Tetsuo Maruyama, Kiichi Hirota, Hidetaka Okada   +8 more
doaj   +1 more source

Development and validation of a stress response measure: the Daily Stress Response Scale (DSRS) [PDF]

, 2022
Background: To date, there is a lack of measures for capturing a broad spectrum of psychophysiological stress reactions that can be administered on a daily basis and in different contexts. A need for such a measure is especially salient in settings where
Debowska, Agata, Boduszek, D., Horeczy, B., Horeczy, Beata, von Bastian, C.C., Dolinski, Dariusz, von Bastian, Claudia C., Dolinski, D., Boduszek, Daniel, Debowska, A., von Bastian, C., Daniel Boduszek, Dariusz Dolinski, Claudia C. von Bastian, Beata Horeczy, Agata Debowska   +15 more
core   +1 more source

Research progress of integrated stress response in pathogenesis of Alzheimer's disease

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Integrated stress response (ISR) is a cellular adaptive response induced by stress, which is strictly regulated by multiple phosphokinases, phosphatases and other proteins to maintain protein homeostasis.
SUN Hui, JIN Hongfu, GUO Shenrui, FENG Yiyuan, YIN Yafu, WANG Hui, CHENG Weiwei   +6 more
doaj   +1 more source

Autophagy and the Integrated Stress Response [PDF]

Molecular Cell, 2010
Autophagy is a tightly regulated pathway involving the lysosomal degradation of cytoplasmic organelles or cytosolic components. This pathway can be stimulated by multiple forms of cellular stress, including nutrient or growth factor deprivation, hypoxia, reactive oxygen species, DNA damage, protein aggregates, damaged organelles, or intracellular ...
Kroemer, Guido, Mariño, Guillermo, Levine, Beth   +2 more
openaire   +2 more sources

Integrated stress responses in Salmonella [PDF]

International Journal of Food Microbiology, 2012
The foodborne gram-negative pathogen Salmonella must adapt to varied environmental conditions encountered within foods, the host gastrointestinal tract and the phagosomes of host macrophages. Adaptation is achieved through the coordinate regulation of gene expression in response to environmental signals such as temperature, pH, osmolarity, redox state,
Shu, Shen, Ferric C, Fang
openaire   +2 more sources

Inhibiting SARS-CoV-2 infection in vitro by suppressing its receptor, angiotensin-converting enzyme 2, via aryl-hydrocarbon receptor signal

Scientific Reports, 2021
Since understanding molecular mechanisms of SARS-CoV-2 infection is extremely important for developing effective therapies against COVID-19, we focused on the internalization mechanism of SARS-CoV-2 via ACE2.
Keiji Tanimoto, Kiichi Hirota, Takahiro Fukazawa, Yoshiyuki Matsuo, Toshihito Nomura, Nazmul Tanuza, Nobuyuki Hirohashi, Hidemasa Bono, Takemasa Sakaguchi   +8 more
doaj   +1 more source

Micro-RNA networks in T-cell prolymphocytic leukemia reflect T-cell activation and shape DNA damage response and survival pathways

Haematologica, 2020
T-cell prolymphocytic leukemia (T-PLL) is a poor-prognostic mature T-cell malignancy. It typically presents with exponentially rising lymphocyte counts, splenomegaly, and bone marrow infiltration.
Till Braun, Markus Glass, Linus Wahnschaffe, Moritz Otte, Petra Mayer, Marek Franitza, Janine Altmüller, Michael Hallek, Stefan Hüttelmaier, Alexandra Schrader, Marco Herling   +10 more
doaj   +1 more source

Architecture, Dynamics, and Function of the General Stress Response System in B. subtilis [PDF]

, 2012
Cells exhibit diverse and dynamic responses to stress. However, in many cases it remains unclear what the dynamics are, how they are generated, and why they are beneficial to the cell or organism. To investigate these issues we studied the General Stress
Young, Jonathan Wan
core   +1 more source