Results 21 to 30 of about 466,137 (253)
Biomedicines, 2021 Cancer cells have the metabolic flexibility to adapt to heterogeneous tumor microenvironments. The integrated stress response (ISR) regulates the cellular adaptation response during nutrient stress.
Mei-Chun Chen +7 more
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A stay of execution: ATF4 regulation and potential outcomes for the integrated stress response
Frontiers in Molecular Neuroscience, 2023 ATF4 is a cellular stress induced bZIP transcription factor that is a hallmark effector of the integrated stress response. The integrated stress response is triggered by phosphorylation of the alpha subunit of the eukaryotic initiation factor 2 complex ...
Graham Neill, Glenn R. Masson
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CCR7 as a novel therapeutic target in t-cell PROLYMPHOCYTIC leukemia
Biomarker Research, 2020 T-cell prolymphocytic leukemia (T-PLL) is a poor prognostic disease with very limited options of efficient therapies. Most patients are refractory to chemotherapies and despite high response rates after alemtuzumab, virtually all patients relapse ...
Carlos Cuesta-Mateos +25 more
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The integrated stress response in budding yeast lifespan extension
Microbial Cell, 2017 Aging is a complex, multi-factorial biological process shared by all living organisms. It is manifested by a gradual accumulation of molecular alterations that lead to the decline of normal physiological functions in a time-dependent fashion.
Spike D.L. Postnikoff +2 more
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From the integrated stress response to oxidative stress: A historical perspective. [PDF]
J Biol ChemOxidative stress has exerted fundamental evolutionary pressure since the emergence of aerobic life. Its impact on the physiology and function of all organisms is profound and consequential for cell survival. The integrated stress response (ISR) plays a critical role in counteracting oxidative stress via translational control of a subset of mRNAs. Here,
Amiri M +4 more
europepmc +3 more sources
Bisphenol A promotes stress granule assembly and modulates the integrated stress response
Biology Open, 2021 Bisphenol-A (BPA) is a ubiquitous precursor of polycarbonate plastics that is found in the blood and serum of >92% of Americans. While BPA has been well documented to act as a weak estrogen receptor (ER) agonist, its effects on cellular stress are ...
Marta M. Fay +17 more
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Frontiers in Immunology, 2023 IntroductionProteasome inhibition is first line therapy in multiple myeloma (MM). The immunological potential of cell death triggered by defects of the ubiquitin-proteasome system (UPS) and subsequent perturbations of protein homeostasis is, however ...
Zeinab Waad Sadiq +8 more
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Integrative analysis of the salt stress response in cyanobacteria [PDF]
Biology Direct, 2021 Abstract Microorganisms evolved specific acclimation strategies to thrive in environments of high or fluctuating salinities. Here, salt acclimation in the model cyanobacterium Synechocystis sp.
Stephan Klähn +5 more
openaire +5 more sources
Innate Immune Recognition, Integrated Stress Response, Infection, and Tumorigenesis
Biology, 2023 Engagement of PRRs in recognition of PAMPs or DAMPs is one of the processes that initiates cellular stress. These sensors are involved in signaling pathways leading to induction of innate immune processes.
Klara Kubelkova +3 more
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Transcriptional Control of Metastasis by Integrated Stress Response Signaling
Frontiers in Oncology, 2021 As a central cellular program to sense and transduce stress signals, the integrated stress response (ISR) pathway has been implicated in cancer initiation and progression. Depending on the genetic mutation landscape, cellular context, and differentiation
Si Lu +10 more
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