Results 41 to 50 of about 10,043,563 (299)

ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes

Cell Reports
Summary: The majority of severe early-onset and juvenile cases of amyotrophic lateral sclerosis (ALS) are caused by mutations in the FUS gene, resulting in rapid disease progression.
Hafiza Alirzayeva, Rute Loureiro, Seda Koyuncu, Franziska Hommen, Yara Nabawi, William Hongyu Zhang, Thien T.P. Dao, Markus Wehrmann, Hyun Ju Lee, David Vilchez   +9 more
doaj   +1 more source

Global expression analysis of the brown alga Ectocarpus siliculosus (Phaeophyceae) reveals large-scale reprogramming of the transcriptome in response to abiotic stress [PDF]

, 2009
Dittami SM, Scornet D, Petit J-L, et al. Global expression analysis of the brown alga Ectocarpus siliculosus (Phaeophyceae) reveals large-scale reprogramming of the transcriptome in response to abiotic stress. Genome Biology.
Boyen, C., Rainer König, Da Silva, Corinne, König, Rainer, Tonon, Thierry, Van de Peer, Y., Ségurens, Béatrice, Thierry Tonon, Dittami, Simon M, Corre, Erwan, Boyen, Catherine, Strerck, Lieven, Simon M Dittami, Dondrup, M., Corinne Da Silva, Glatting, K.-H., Cock, J.M., Dittami, Simon, Da Silva, C., Lieven, Sterck, Corre, E., Cock, J. Marc, Tonon, T., Glatting, Karl-Heinz, Cock, J Mark, Sterck, L., Béatrice Ségurens, J Mark Cock, Van de Peer, Yves, Lieven Sterck, Cock, J. Mark, Dittami, Simon M., Rouzé, Pierre, Erwan Corre, Sterck, Lieven, Dondrup, Michael, Catherine Boyen, Petit, Jean-Louis, Delphine Scornet, Scornet, Delphine, Dittami, S.M., Segurens, B., Rouzé, P., Jean-Louis Petit, Karl-Heinz Glatting, Michael Dondrup, Pierre Rouzé, Scornet, D., König, R., Petit, J.-L., Yves Van de Peer   +50 more
core   +1 more source

EIF2α phosphorylation: a hallmark of both autophagy and immunogenic cell death

Molecular & Cellular Oncology, 2020
Different intrinsic and extrinsic stress pathways including endoplasmic reticulum (ER) stress converge on the phosphorylation of eukaryotic translation initiation factor 2A (EIF2A, best known as eIF2α), which characterizes the so-called “integrated ...
Juliette Humeau, Lucillia Bezu, Oliver Kepp, Guido Kroemer   +3 more
doaj   +1 more source

eIF2B-capturing viral protein NSs suppresses the integrated stress response

Nature Communications, 2021
Here the authors show that a viral protein interferes with the binding of phosphorylated eIF2 to eIF2B, thereby suppressing the host integrated stress response (ISR). This suppression of the ISR abrogates translational changes of the host and ameliorates
Kazuhiro Kashiwagi, Yuichi Shichino, Tatsuya Osaki, Ayako Sakamoto, Madoka Nishimoto, Mari Takahashi, Mari Mito, Friedemann Weber, Yoshiho Ikeuchi, Shintaro Iwasaki, Takuhiro Ito   +10 more
doaj   +1 more source

Schematic overview of the unfolded protein response (UPR) and integrated stress response (ISR).

, 2015
Schematic overview of the unfolded protein response (UPR) and integrated stress response (ISR).
Lucy E. Dalton (756195), Emily F. A. van ‘t Wout (756193), Stefan J. Marciniak (606849), Jan Tommassen (208118), Hanna J. Clarke (756196), Pieter S. Hiemstra (140286), Annemarie van Schadewijk (84908), Ria van Boxtel (756194)   +7 more
core   +1 more source

Contributions of Ccr4 and Gcn2 to the Translational Response of C. neoformans to Host-Relevant Stressors and Integrated Stress Response Induction

mBio, 2023
In response to the host environment, the human pathogen Cryptococcus neoformans must rapidly reprogram its translatome from one which promotes growth to one which is responsive to host stress.
Corey M. Knowles, David Goich, Amanda L. M. Bloom, Murat C. Kalem, John C. Panepinto   +4 more
doaj   +1 more source

Bridging the Loneliness Gap: Depression, Connectivity, and Isolation in Pediatric Oncology Patients and Their Peers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld, Scott H. Maurer, Michelle D. Watkinson, John Nury, Elise Barberis, Molly C. Mack   +5 more
wiley   +1 more source

Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution [PDF]

, 2014
Chronic endoplasmic reticulum (ER) stress results in toxicity that contributes to multiple human disorders. We report a stress resolution pathway initiated by the nuclear receptor LRH-1 that is independent of known unfolded protein response (UPR ...
DeMayo, Fransesco J., San-Pin Wu, David D Moore, Moore, David D, Whitby, Richard J., Martin Wagner, Moore, David D., Peter J Stambrook, Whitby, Richard J, Sifers, Richard N, Ming-Jer Tsai, Francesco J DeMayo, Wu, San-pin, Mamrosh, Jennifer L, Jennifer L Mamrosh, Lee, Jae Man, Sifers, Richard N., Richard N Sifers, Richard J Whitby, Stambrook, Peter J, Stambrook, Peter J., Jae Man Lee, Wagner, Martin, Tsai, Ming-jer, Lee, Jae M., DeMayo, Francesco J, Mamrosh, Jennifer L.   +26 more
core   +1 more source

Arsenicals, the Integrated Stress Response, and Epstein–Barr Virus Lytic Gene Expression

Viruses, 2021
Following our observation that clofoctol led to Epstein–Barr virus (EBV) lytic gene expression upon activation of the integrated stress response (ISR), we decided to investigate the impact of As2O3 on viral lytic gene expression.
Jaeyeun Lee, Jennifer Stone, Prashant Desai, John G. Kosowicz, Jun O. Liu, Richard F. Ambinder   +5 more
doaj   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source