Results 51 to 60 of about 10,043,563 (299)

Wnt regulates amino-acid transporter Slc7a5 and so constrains the integrated stress response in mouse embryos [PDF]

, 2019
Amino-acids are essential for cellular metabolism and it is important to understand how nutrient supply is coordinated with changing energy requirements during embryogenesis. Here we show that the amino-acid transporter Slc7a5/Lat1 is highly expressed in
Kate G Storey, Terry P Yamaguchi, Dady, Alwyn, Alwyn Dady, Taylor, Peter, Peter M Taylor, Gail A Singer, Melanie Febrer, Poncet, Nadège, Halley, Pamela, Yamaguchi, Terry P., Nadège Poncet, Lipina, Christopher, Marek Gierliński, Yun‐Bo Shi, Gierlinski, Marek, Singer, Gail, Febrer, Melanie, Christopher Lipina, Shi, Yun-Bo, Storey, Kate, Pamela A Halley, Taylor, Peter M, Shi, Yun‐Bo, Singer, Gail A, Storey, Kate G, Halley, Pamela A, Yamaguchi, Terry P   +27 more
core   +1 more source

Inhibition of the integrated stress response reverses oxidative stress damage-induced postoperative cognitive dysfunction

Frontiers in Cellular Neuroscience, 2022
Postoperative cognitive dysfunction (POCD) is a common complication following anesthesia and surgery that might lead to a decline in learning and memory. Oxidative stress damage is one of the pathogenic mechanisms underlying POCD.
Linhao Jiang, Linhao Jiang, Linhao Jiang, Linhao Jiang, Rui Dong, Rui Dong, Rui Dong, Rui Dong, Minhui Xu, Minhui Xu, Minhui Xu, Yujia Liu, Yujia Liu, Yujia Liu, Yujia Liu, Jiyan Xu, Jiyan Xu, Jiyan Xu, Jiyan Xu, Zhengliang Ma, Tianjiao Xia, Tianjiao Xia, Tianjiao Xia, Xiaoping Gu   +23 more
doaj   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Integrated metabolomics for abiotic stress responses in plants [PDF]

Current Opinion in Plant Biology, 2015
Plants are considered to biosynthesize specialized (traditionally called secondary) metabolites to adapt to environmental stresses such as biotic and abiotic stresses. The majority of specialized metabolites induced by abiotic stress characteristically exhibit antioxidative activity in vitro, but their function in vivo is largely yet to be ...
Ryo, Nakabayashi, Kazuki, Saito
openaire   +2 more sources

From the integrated stress response to oxidative stress: A historical perspective. [PDF]

J Biol Chem
Oxidative stress has exerted fundamental evolutionary pressure since the emergence of aerobic life. Its impact on the physiology and function of all organisms is profound and consequential for cell survival. The integrated stress response (ISR) plays a critical role in counteracting oxidative stress via translational control of a subset of mRNAs. Here,
Amiri M, Toboz P, Bellucci MA, Tahmasebi S, Sonenberg N.   +4 more
europepmc   +3 more sources

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

Reduction of photosynthetic sensitivity in response to abiotic stress in tomato is mediated by a new generation plant activator [PDF]

, 2013
Background: Yield losses as a result of abiotic stress factors present a significant challenge for the future of global food production. While breeding technologies provide potential to combat negative stress-mediated outcomes over time, interventions ...
Pickup, Doug, Douglas A Pickup, Nigel D Paul, Jason J Wargent, Paul, Nigel D., Roberts, Michael R., Michael R Roberts, Wargent, Jason J.   +7 more
core   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Plant molecular response to combined drought and nematode stress [PDF]

, 2011
Plants are adapted to respond to precise environmental stress conditions, activating specific molecular and physiological changes in order to minimise damage.
Atkinson, Nicola Jane
core  

Neuronal Mitochondrial Dysfunction Activates the Integrated Stress Response to Induce Fibroblast Growth Factor 21 [PDF]

, 2018
Stress adaptation is essential for neuronal health. While the fundamental role of mitochondria in neuronal development has been demonstrated, it is still not clear how adult neurons respond to alterations in mitochondrial function and how neurons sense ...
Albert Neutzner, Giovanna Mallucci, Eckert, Anne, Björn Oettinghaus, Frank, Stephan, Licci, Maria, Restelli, Lisa Michelle, SAVOIA, CLAUDIA, Oettinghaus, Björn, Claudia Savoia, Sironi, Lara, Markus Tolnay, Alexander Schmidt, Scorrano, Luca, Lisa Michelle Restelli, Lara Sironi, Mallucci, Giovanna, Halliday, Mark, Luca Scorrano, Hench, Jürgen, Maria Licci, Mark Halliday, Tolnay, Markus, Cavit Agca, Stephan Frank, Agca, Cavit, Jürgen Hench, Schmidt, Alexander, Neutzner, Albert, Anne Eckert, Oettinghaus B, Agca C, Savoia C, Schmidt A, Halliday M, Restelli LM, Licci M, Sironi L, Hench J, Mallucci G, Frank S, Scorrano L, Eckert A, Neutzner A, Tolnay M   +44 more
core   +2 more sources