Results 71 to 80 of about 10,095,518 (284)
Daily life stress and the cortisol awakening response: testing the anticipation hypothesis [PDF]
, 2012 The cortisol awakening response (CAR) is a distinct facet of the circadian cortisol rhythm associated with various health conditions and risk factors.
Schlotz, Wolff +8 more
core +2 more sources
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
The integrated stress response system in cardiovascular disease
Drug Discovery Today, 2018 The integrated stress response system represents an ancillary, extremely conserved signalling pathway present in virtually all eukaryotic cells, which plays an important part in the pathophysiology of several disorders such as cancer and neurodegeneration. However, its role in the cardiovascular system remains largely elusive.
Diana, Santos-Ribeiro +3 more
openaire +2 more sources
Integrated Endoplasmic Reticulum Stress Responses in Cancer [PDF]
Cancer Research, 2007 Abstract The endoplasmic reticulum (ER) has emerged as a major site of cellular homeostasis regulation, particularly in the unfolded protein response, which is being found to play a major role in cancer and many other diseases. Here, we address ER-mediated signaling and regulations in the context of environmental challenges in cancer ...
Michel, Moenner +3 more
openaire +2 more sources
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Heat stress severely constrains wheat productivity, yet the mechanisms underlying thermotolerance remain incompletely understood. This study integrated physiological, biochemical, molecular, and ultrastructural analyses to characterize heat-stress ...
Irada M. Huseynova +5 more
core +1 more source
WRKY Transcription Factor Response to High-Temperature Stress
, 2021 Plant growth and development are closely related to the environment, and high-temperature stress is an important environmental factor that affects these processes.
Jing Sun +5 more
core +1 more source
The integrated stress response: From mechanism to disease
Science, 2020 Proteostasis dISRupted Despite their importance, many crucial networks for protein quality control within cells diminish with age. The resulting loss of proteostasis, the process by which the health of a cell's proteins is monitored and maintained, is associated with a wide range of age-related human diseases. Costa-Mattioli and Walter review
Mauro Costa-Mattioli, Peter Walter
openaire +4 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source